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Volume 11 (22); 2020

Research Papers

Prognostic impact of tumor budding and EMT in periampullary adenocarcinoma: a quantitative approach
Éva Kocsmár, Gábor Lotz, András Kiss, Markus Hoerner, Ekaterina Petrova, Nikolaus Freudenberg, Ágnes Csanádi, Birte Kulemann, Martin Werner, Peter Bronsert, Ulrich Friedrich Wellner
J. Cancer 2020; 11(22): 6474-6483. doi:10.7150/jca.46093
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Survival outcomes of low prostate-specific antigen levels and T stages in patients with high-grade prostate cancer: a population-matched study
Yongming Kang, Pan Song, Kun Fang, Bo Yang, Luchen Yang, Jing Zhou, Linchuan Wang, Qiang Dong
J. Cancer 2020; 11(22): 6484-6490. doi:10.7150/jca.40428
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Improved diagnostic value by combining plasma PON1 level with tumor biomarkers in Colorectal Cancer patients
Jingdan Zhang, Xiangling Yang, Lili Wei, Huiliu Tan, Junxiong Chen, Weiqian Li, Kawo Chan, Yixi Su, Lu Zhao, Suhua Hu, Shuoxian Zhong, Yanhong Xiao, Huanliang Liu
J. Cancer 2020; 11(22): 6491-6496. doi:10.7150/jca.45204
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Doxorubicin uptake in ascitic lymphoma model: resistance or curability is governed by tumor cell density and prolonged drug retention
Gintaras Zaleskis, Sima Garberytė, Božena Pavliukevičienė, Gintaras Valinčius, Dainius Characiejus, Mykolas Mauricas, Jan Aleksander Kraśko, Karolina Žilionytė, Margarita Žvirblė, Vita Pašukonienė
J. Cancer 2020; 11(22): 6497-6506. doi:10.7150/jca.46066
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Genetic variants in the Folic acid Metabolic Pathway Genes predict outcomes of metastatic Colorectal Cancer patients receiving first-line Chemotherapy
Lu Jiang, Shuwei Li, Ming Yuan, Ling Ma, Yu Lin, Weiyou Zhu, Haina Du, Meilin Wang, Tao Chen, Lingjun Zhu
J. Cancer 2020; 11(22): 6507-6515. doi:10.7150/jca.44580
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma
Guanxia Zhu, Xia Li, Jiong Li, Wei Zhou, Zhongjian Chen, Yun Fan, Youhua Jiang, Yue Zhao, Guogui Sun, Weimin Mao
J. Cancer 2020; 11(22): 6516-6529. doi:10.7150/jca.47111
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Prognostic alternative splicing signature reveals the landscape of immune infiltration in Pancreatic Cancer
Lin Wang, Jia Bi, Xueping Li, Minjie Wei, Miao He, Lin Zhao
J. Cancer 2020; 11(22): 6530-6544. doi:10.7150/jca.47877
[Abstract] [Full text] [PDF] [PubMed] [PMC]

miR-96 regulates liver tumor-initiating cells expansion by targeting TP53INP1 and predicts Sorafenib resistance
Yonggang Huang, Jin Zhang, HengYu Li, Huiping Peng, Maolin Gu, Hengjie Wang
J. Cancer 2020; 11(22): 6545-6555. doi:10.7150/jca.48333
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Icaritin reduces prostate cancer progression via inhibiting high-fat diet-induced serum adipokine in TRAMP mice model
Xiaobo Wu, Xingbo Long, Chen Yang, Huan Chen, Christina Sharkey, Khalid Rashid, Mengbo Hu, Yufei Liu, Qi Huang, Qi Chen, Jimeng Hu, Haowen Jiang
J. Cancer 2020; 11(22): 6556-6564. doi:10.7150/jca.48413
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CEA Decline Predicts Tumor Regression and Prognosis in Locally Advanced Rectal Cancer Patients with Elevated Baseline CEA
Zerong Cai, Lingyu Huang, Yufeng Chen, Xiaoyu Xie, Yifeng Zou, Ping Lan, Xiaojian Wu
J. Cancer 2020; 11(22): 6565-6570. doi:10.7150/jca.49252
[Abstract] [Full text] [PDF] [PubMed] [PMC]

High level of interleukin-33 in cancer cells and cancer-associated fibroblasts correlates with good prognosis and suppressed migration in cholangiocarcinoma
Supaporn Yangngam, Suyanee Thongchot, Ananya Pongpaibul, Kulthida Vaeteewoottacharn, Somchai Pinlaor, Peti Thuwajit, Seiji Okada, Chanitra Thuwajit
J. Cancer 2020; 11(22): 6571-6581. doi:10.7150/jca.48327
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Loss of ACSM3 confers worsened prognosis and immune exclusion to cutaneous melanoma
Zhidong Zhu, Duoqin Wang, Yanyun Shen
J. Cancer 2020; 11(22): 6582-6590. doi:10.7150/jca.48354
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Biological functions and prognostic value of RNA Binding Proteins in clear cell Renal Cell Carcinoma
Zhenpeng Zhu, Anbang He, Lanruo Lin, Chunru Xu, Tianyu Cai, Jian Lin
J. Cancer 2020; 11(22): 6591-6600. doi:10.7150/jca.49175
[Abstract] [Full text] [PDF] [PubMed] [PMC]

PRIM1 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
Jinqun Jiang, YuZhu Zhang, Rui Xu, Liping Ren, Junqian Chen, Hai Lu
J. Cancer 2020; 11(22): 6601-6611. doi:10.7150/jca.47870
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Efficacy and Safety of Fulvestrant 500mg in Hormone-receptor Positive Human Epidermal Receptor 2 Negative Advanced Breast Cancer: A Real-world Study in China
Wen Lei, Huiping Li, Guohong Song, Ruyan Zhang, Ran Ran, Ying Yan, Lijun Di, Hanfang Jiang
J. Cancer 2020; 11(22): 6612-6622. doi:10.7150/jca.47960
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Long Noncoding RNA DSCAM-AS1 Facilitates Colorectal Cancer Cell Proliferation and Migration via miR-137/Notch1 Axis
Jing Xu, Guanghai Wu, Yongjie Zhao, Youkui Han, Shuai Zhang, Chao Li, Judong Zhang
J. Cancer 2020; 11(22): 6623-6632. doi:10.7150/jca.46562
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Nitroxoline inhibits bladder cancer progression by reversing EMT process and enhancing anti-tumor immunity
Naijin Xu, Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Abai Xu, Masami Watanabe, Kai Guo, Motoo Araki, Gonghui Li, Chunxiao Liu, Yasutomo Nasu, Peng Huang
J. Cancer 2020; 11(22): 6633-6641. doi:10.7150/jca.47025
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Development and Assessment of Novel Predictive Nomograms Based on APRI for Hepatitis B Virus-associated Small Solitary Hepatocellular Carcinoma with Stereotactic Body Radiotherapy
Lin Lai, Tingshi Su, Zhongguo Liang, Yunxing Lu, Encun Hou, Zuping Lian, Hongjun Gao, Xiaodong Zhu
J. Cancer 2020; 11(22): 6642-6652. doi:10.7150/jca.47291
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The taxane-based chemotherapy triplet is superior to the doublet in one to nine node-positive but not node-negative triple-negative breast cancer: results from a retrospective analysis
Sanxing Guo, Yonggang Shi, Shuo Lu, Yujie He, Guangyi Jin, Suzhi Zhang, Xingya Li
J. Cancer 2020; 11(22): 6653-6662. doi:10.7150/jca.44768
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Overexpression of KIAA0101 Promotes the Progression of Non-small Cell Lung Cancer
He Cao, Jing Zheng, Yinan Yao, Qi Yang, Runlan Yan, Wenjia Sun, Kexin Ruan, Jianya Zhou, Jianying Zhou
J. Cancer 2020; 11(22): 6663-6674. doi:10.7150/jca.45962
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD)
Jieru Zhang, Hui Xu, Xiaomei Yang, Yuanjie Zhao, Xinchun Xu, Ling Zhang, Xiaofeng Xuan, Chunping Ma, Wenxia Qian, Dawei Li
J. Cancer 2020; 11(22): 6675-6685. doi:10.7150/jca.46146
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Clinical analysis of EBRT vs TLM in the treatment of early (T1-T2N0) glottic laryngeal cancer
Jing Shen, Ke Hu, Jiabin Ma, Hongnan Zhen, Hui Guan, Wenhui Wang, Fuquan Zhang
J. Cancer 2020; 11(22): 6686-6694. doi:10.7150/jca.46487
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Landscape of FGF/FGFR Alterations in 12,372 Chinese Cancer Patients
Wei Zuo, Yan He, Wei Li, Hao Wu, Zhengyi Zhao, Yuzi Zhang, Shiqing Chen, Yongmei Yin
J. Cancer 2020; 11(22): 6695-6699. doi:10.7150/jca.49269
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
Tuan Wang, Xia Wu, Mus'ab Al rudaisat, Yinjing Song, Hao Cheng
J. Cancer 2020; 11(22): 6704-6715. doi:10.7150/jca.45176
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Personalizing prognostic prediction in early-onset Colorectal Cancer
Jian Liu, Zhengru Liu, Jiao Li, Shan Tian, Weiguo Dong
J. Cancer 2020; 11(22): 6727-6736. doi:10.7150/jca.46871
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reciprocal regulation of HIF-1α and Uroplakin 1A promotes glycolysis and proliferation in Hepatocellular Carcinoma
Yang Song, Hui Wang, Xue-Jing Zou, Ya-Xuan Zhang, Ze-Qin Guo, Li Liu, De-Hua Wu, Dong-Yan Zhang
J. Cancer 2020; 11(22): 6737-6747. doi:10.7150/jca.48132
[Abstract] [Full text] [PDF] [PubMed] [PMC]

YAP increases response to Trastuzumab in HER2-positive Breast Cancer by enhancing P73-induced apoptosis
Lanqing Cao, Min Yao, Hironobu Sasano, Ping-Li Sun, Hongwen Gao
J. Cancer 2020; 11(22): 6748-6759. doi:10.7150/jca.48535
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication

Negative Effects On Cancer Care Due To COVID-19 Implications: Observations From A Cancer Center In The UAE
Shaheenah Dawood, Zulfaqqar Jaffar, Zakir K Mohamed, Annett Al-Hamadi, Zakaullah Khan
J. Cancer 2020; 11(22): 6700-6702. doi:10.7150/jca.51792
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers
Meng Zhou, Yuncui Wu, Hongwu Li, Xiaojun Zha
J. Cancer 2020; 11(22): 6716-6726. doi:10.7150/jca.46293
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum

B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A: Erratum
Yanchao Ma, Ruoqin Wang, Huimin Lu, Xiaomi Li, Guangbo Zhang, Fengqing Fu, Lei Cao, Shenghua Zhan, Zhenxin Wang, Zhongbin Deng, Tongguo Shi, Xueguang Zhang, Weichang Chen
J. Cancer 2020; 11(22): 6703. doi:10.7150/jca.53041
[Abstract] [Full text] [PDF] [PubMed] [PMC]