Impact Factor ISSN: 1837-9664
Review Tumor Treating Fields in Solid Tumors: A Multiscale Evidence Framework with Gastric Cancer as an Early Translational Case Study Full text PDF
Research Paper Systemic Immune Traits and Candidate Genes in Uveal Melanoma: An Exploratory Mendelian Randomization and Transcriptomic Study Full text PDF
Research Paper Dynamic Postoperative Skeletal Muscle Trajectories Predict Survival in Stage II-III Gastric Cancer Full text PDF
Research Paper RFC1, RPA1, and POLE expression characterizes the clinical behavior and immune microenvironment of colorectal cancer Full text PDF
Review Who Should Undergo Surgery, and at What Operative Risk? Two Conditions Governing Cytoreduction in TKI-Treated Gastrointestinal Stromal Tumor Full text PDF
Research Paper Integrative Locus-Resolved Genomics Uncovers Distinct Genetic Links Between Leukocyte Telomere Length and Colon Cancer Susceptibility Full text PDF
Issue 11; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Background: Colorectal cancer remains a major cause of cancer-related mortality, and reliable biomarkers associated with prognosis and the tumor immune microenvironment are still needed. Replication-associated proteins, including RFC1, RPA1, and POLE, participate in DNA replication and repair processes and may contribute to colorectal cancer biology. However, their expression patterns and clinical significance remain insufficiently characterized. ...
Background: Leukocyte telomere length (LTL) is a heritable marker of telomere-maintenance biology and has been implicated in cancer susceptibility. Whether LTL and colon cancer share inherited genetic architecture remains unclear. Methods: We integrated GWAS summary statistics for LTL and colon cancer using a cross-trait post-GWAS framework. Genome-wide and local genetic sharing were assessed using LDSC, HDL, MiXeR and SUPERGNOVA, while pleiotropic ...