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Research Paper Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer Full text PDF
Research Paper Functional Stratification and Long-Term Care Service Patterns among Discharged Patients with Cancer: A Retrospective Study from Taiwan Full text PDF
Research Paper Multi-omics Data Reveal SLC9A3R2 Promotes Breast Cancer Progression and an Immunosuppressive Microenvironment Full text PDF
Research Paper Integrative Machine Learning Framework Revealing TRPM4-Associated Signatures and Identifying SPATA6 as a Potential Biomarker in Prostate Cancer Full text PDF
Research Paper Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress Full text PDF
Research Paper Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients Full text PDF
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Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress
Lung cancer remains the leading cause of cancer-related mortality worldwide, yet its molecular pathogenesis is not fully understood. Here, we identify HADHB, encoding a mitochondrial β-ketothiolase as a novel oncogene in lung cancer. Using a HadhbPB/PB mouse model, we demonstrate that Hadhb deficiency in mice significantly suppresses K-RasG12D-driven lung tumor progression by impairing cancer cell proliferation and enhancing apoptosis. Mechanistically, ...
Background: As cancer survival improves, a growing number of patients experience functional decline and require supportive care and long-term care after hospitalization. However, the relationship between functional severity and post-discharge long-term care utilization in patients with cancer remains insufficiently characterized. This study examined long-term care service patterns across functional severity levels, as classified by a Case-Mix System, ...