Impact Factor ISSN: 1837-9664
Research Paper Integrative Locus-Resolved Genomics Uncovers Distinct Genetic Links Between Leukocyte Telomere Length and Colon Cancer Susceptibility Full text PDF
Research Paper [177Lu]Lu-PSMA-617-Mediated Endoradiotherapy of Breast Cancer by Targeting Tumor-Associated Neovasculature Full text PDF
Review Delayed First Childbirth Reshapes Postpartum Breast Cancer Risk: A Biphasic Model Full text PDF
Research Paper Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study Full text PDF PubMed PMC
Research Paper An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD Full text PDF PubMed PMC
Research Paper FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer Full text PDF PubMed PMC
Issue 10; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Background: The role of Filamin A (FLNA) in colorectal cancer (CRC), particularly within the stromal compartment, remains poorly defined. This study investigates its expression, function, and clinical relevance in CRC. Methods: We integrated transcriptomic data from the GSE39582 training cohort and TCGA/GSE75316 validation cohorts. Analyses included functional enrichment, tumor microenvironment (TME) assessment (ESTIMATE, TIDE), immune correlation, ...
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Prostate-specific membrane antigen (PSMA) is expressed on the neovasculature of many solid tumors, including breast cancer, making it a potential vascular target for radioligand therapy (RLT). However, whether the therapeutic efficacy of the clinically approved PSMA-targeted radioligand [177Lu]Lu-PSMA-617 in TNBC is strictly dependent on ...