Impact Factor ISSN: 1837-9664
Research Paper Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study Full text PDF
Research Paper An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD Full text PDF
Research Paper FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer Full text PDF
Research Paper Impact of FOSL1 polymorphisms and expression on disease progression in oral tongue squamous cell carcinoma Full text PDF
Research Paper The scPagwas analysis of single-cell sequencing combined with Bayesian deconvolution with SMR Reveals Tumor Heterogeneity and Predicts Immunotherapy Response in Neuroblastoma Full text PDF
Research Paper P-cadherin Overexpression Induces Partial Epithelial-to-Mesenchymal Transition and Confers Chemoresistance in Dysplastic Oral Epithelial Cells Full text PDF
Issue 10; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Chemoresistance is a major barrier to the successful treatment of oral squamous cell carcinoma. The dysplasia stage of oral tumor progression is associated with increased levels of antiapoptotic mediators as well as the cell adhesion protein placental cadherin (P-cadherin). The mechanisms by which P-cadherin may contribute to tumor progression in dysplastic oral epithelia remain unclear. In the present study, a dysplastic oral keratinocyte (DOK) cell ...
Background: Extensive-stage small-cell lung cancer (ES-SCLC) remains an aggressive malignancy with poor survival despite platinum-etoposide chemotherapy. Although serplulimab plus chemotherapy has demonstrated a survival benefit in randomized trials, comparative real-world evidence remains limited. We therefore evaluated survival outcomes with first-line serplulimab plus chemotherapy versus chemotherapy alone in patients with ES-SCLC. Methods: We ...