Impact Factor ISSN: 1837-9664
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Research Paper Integrated Pan-Cancer, Single-Cell, and Spatial Transcriptomic Analyses Identify ZDHHC12 as a Biomarker Associated with Macrophage Infiltration and the Immune Landscape in Glioma Full text PDF
Review Liquid Biopsy and Nonendoscopic Biomarkers for Precision Early Detection of Esophageal Cancer: Evidence, Risk Stratification and Translational Challenges Full text PDF
Research Paper Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma Full text PDF
Research Paper Chronically Established ρ0 Cancer Cells Exhibit Shared Stemness-Associated and Aggressive Phenotypes Across Multiple Cancer Cell Lines Full text PDF
Review Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms and Therapeutic Strategies Full text PDF
Research Paper Cofilin/RhoA and CREB synergistically promote invasion and migration of polyploid giant cancer cells in colorectal cancer Full text PDF
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Chronically established mitochondrial DNA-depleted (ρ0) cancer cells may exhibit phenotypic changes beyond metabolic dysfunction; however, whether such changes are shared across different cancer types remains unclear. In this study, we generated chronically established ρ0 models from pancreatic, lung, and breast cancer cell lines and examined their common phenotypic features. Compared with their parental wild-type counterparts, the ρ0 ...
Esophageal cancer remains one of the most lethal malignancies worldwide, largely because most tumors are detected after symptoms develop. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) differ in epidemiology, precursor lesions and molecular biology, and therefore require subtype-specific early-detection pathways. This narrative critical review used a structured PubMed/MEDLINE search and classifies evidence by intended ...