Impact Factor ISSN: 1837-9664
Research Paper Integrative Locus-Resolved Genomics Uncovers Distinct Genetic Links Between Leukocyte Telomere Length and Colon Cancer Susceptibility Full text PDF
Research Paper [177Lu]Lu-PSMA-617-Mediated Endoradiotherapy of Breast Cancer by Targeting Tumor-Associated Neovasculature Full text PDF
Review Delayed First Childbirth Reshapes Postpartum Breast Cancer Risk: A Biphasic Model Full text PDF
Research Paper Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study Full text PDF PubMed PMC
Research Paper An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD Full text PDF PubMed PMC
Research Paper FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer Full text PDF PubMed PMC
Issue 10; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Delayed First Childbirth Reshapes Postpartum Breast Cancer Risk: A Biphasic Model
Delayed first childbirth (35-39 y) is a rapidly rising global exposure that reshapes postpartum breast cancer (PPBC) risk in a biphasic manner: a prolonged short-term risk peak (hazard ratio 1.40 at 6.4 years postpartum) coupled with long-term protection delayed beyond 15 years. Synthesizing 15 prospective cohorts with single-cell and spatial atlases of the aging parous mammary gland, we propose that maternal age is a dual modifier of PPBC risk. First, ...
Background: Leukocyte telomere length (LTL) is a heritable marker of telomere-maintenance biology and has been implicated in cancer susceptibility. Whether LTL and colon cancer share inherited genetic architecture remains unclear. Methods: We integrated GWAS summary statistics for LTL and colon cancer using a cross-trait post-GWAS framework. Genome-wide and local genetic sharing were assessed using LDSC, HDL, MiXeR and SUPERGNOVA, while pleiotropic ...