Impact Factor ISSN: 1837-9664
Review Advances in CAR-T Cell Therapy: From Structural Design Innovations to Clinical Translation Challenges Full text PDF
Review Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors Full text PDF
Research Paper Integrated Pan-Cancer, Single-Cell, and Spatial Transcriptomic Analyses Identify ZDHHC12 as a Biomarker Associated with Macrophage Infiltration and the Immune Landscape in Glioma Full text PDF
Review Liquid Biopsy and Nonendoscopic Biomarkers for Precision Early Detection of Esophageal Cancer: Evidence, Risk Stratification and Translational Challenges Full text PDF
Research Paper Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma Full text PDF
Research Paper Chronically Established ρ0 Cancer Cells Exhibit Shared Stemness-Associated and Aggressive Phenotypes Across Multiple Cancer Cell Lines Full text PDF
Issue 9; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Chronically established mitochondrial DNA-depleted (ρ0) cancer cells may exhibit phenotypic changes beyond metabolic dysfunction; however, whether such changes are shared across different cancer types remains unclear. In this study, we generated chronically established ρ0 models from pancreatic, lung, and breast cancer cell lines and examined their common phenotypic features. Compared with their parental wild-type counterparts, the ρ0 ...
Background: Smoking history is associated with improved immune checkpoint inhibitor treatment responses. We investigated smoking-associated differences in the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) and identified biomarkers associated with tertiary lymphoid structure (TLS) formation. Methods: Single-cell RNA-sequencing datasets from tumors and matched adjacent normal tissues from five current smokers and five never-smokers with ...