Impact Factor ISSN: 1837-9664
Research Paper Integrative Locus-Resolved Genomics Uncovers Distinct Genetic Links Between Leukocyte Telomere Length and Colon Cancer Susceptibility Full text PDF
Research Paper [177Lu]Lu-PSMA-617-Mediated Endoradiotherapy of Breast Cancer by Targeting Tumor-Associated Neovasculature Full text PDF
Review Delayed First Childbirth Reshapes Postpartum Breast Cancer Risk: A Biphasic Model Full text PDF
Research Paper Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study Full text PDF PubMed PMC
Research Paper An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD Full text PDF PubMed PMC
Research Paper FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer Full text PDF PubMed PMC
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Background: Leukocyte telomere length (LTL) is a heritable marker of telomere-maintenance biology and has been implicated in cancer susceptibility. Whether LTL and colon cancer share inherited genetic architecture remains unclear. Methods: We integrated GWAS summary statistics for LTL and colon cancer using a cross-trait post-GWAS framework. Genome-wide and local genetic sharing were assessed using LDSC, HDL, MiXeR and SUPERGNOVA, while pleiotropic ...
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. Prostate-specific membrane antigen (PSMA) is expressed on the neovasculature of many solid tumors, including breast cancer, making it a potential vascular target for radioligand therapy (RLT). However, whether the therapeutic efficacy of the clinically approved PSMA-targeted radioligand [177Lu]Lu-PSMA-617 in TNBC is strictly dependent on ...