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Research Paper GPCRs interaction with LGR5: Implications to cancer stemness Jeetendra K Nag, Ganesh Subedi, Tatyana Rudina, Rachel Bar-Shavit J. Cancer 2026; 17(8): 1408-1418. doi:10.7150/jca.134767 Full text PDF


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Research Paper Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis Xiaozheng Ou, Jinghong Xu, Yuting Jin, Yanqing Wang, Rongmin Yu, Jianhua Zhu, Weijuan Huang, Liyan Song J. Cancer 2026; 17(7): 1393-1407. doi:10.7150/jca.128611 Full text PDF


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Review tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis Congcong Tang, Qi Tang, Siyuan Tang, Faqing Tang J. Cancer 2026; 17(7): 1384-1392. doi:10.7150/jca.135857 Full text PDF


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Research Paper Long-Term Empagliflozin Treatment (50 Days) Attenuates Protease Activity, Migration, and Stemness-Associated Phenotypes in BFTC-909 Renal Pelvis Transitional Cell Carcinoma Cells Yi-Hsun Lee, Pei-Ni Chen, Yi-Hsien Hsieh, Yi-Cheng Chu, Li-Jeng Chen, Chin-Yin Lin, Shun-Fa Yang, Horng-Rong Chang J. Cancer 2026; 17(7): 1373-1383. doi:10.7150/jca.132959 Full text PDF


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Research Paper A digital polymerase chain reaction method targeting non-recombined T-cell receptor sequences aids in diagnosing primary cutaneous T-cell lymphomas Chien-Chin Chen, Cheng-Lin Wu, Bo-Jiun Tzeng, Pin-Jun Chen, Wan-Li Chen, Sern Yan Lim, Yi-Ling Chen, Yi-Lin Chen, Chung-Liang Ho, Tsunglin Liu J. Cancer 2026; 17(7): 1362-1372. doi:10.7150/jca.136694 Full text PDF


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Research Paper Single-cell Transcriptomics Uncovers the Tumor Microenvironment and Collagen-CD44 Axis in HIV Positive Cervical Squamous Cell Carcinoma Yuxi Ma, Lijun Zhang, Liangfei Niu, Bo Yan, Min Liu J. Cancer 2026; 17(7): 1346-1361. doi:10.7150/jca.134138 Full text PDF

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GPCRs interaction with LGR5: Implications to cancer stemness

Background/Objectives: The central role of G-protein coupled receptors (GPCRs) in tumor biology is becoming acknowledged. Yet their involvement in cancer stem cells (CSCs) niche is unknown. Molecular mechanisms of CSCs allow self-formation capacity, resistance to chemotherapy and immune therapy. Methods: Western blots, Co-immunoprecipitation (co-IP) analysis, RT-PCR, Lef/Tcf luciferase activity and Alpha Fold3 HANDDOCK v2.4 protein-protein docking ...


Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis

Purpose: Drug resistance in colorectal cancer (CRC) necessitates novel therapeutic strategies. This study investigated whether arteannuin B, a sesquiterpene lactone from Artemisia annua, induces ferroptosis in CRC cells and elucidated the underlying molecular mechanism. Methods: Anti-CRC effects were assessed via MTT assays and xenograft models. Proteomics identified differentially expressed proteins. Arteannuin B-induced ferroptosis was confirmed ...

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