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Research Paper Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma Full text PDF
Research Paper Serum Thyroid Biomarkers for Diagnosing Malignant Thyroid Nodules: A Machine Learning Approach with External and Causal Validation Full text PDF
Research Paper MRI-Based Habitat Radiomics for Differentiating Early-Stage Endometrial Carcinoma from Submucous Leiomyoma: A Multicenter Validation Study Full text PDF
Research Paper Integrative Bulk and Single-Cell Transcriptome Profiling of Telomere-Related Genes Reveals a Robust Prognostic Signature and Immunotherapeutic Landscape in Neuroblastoma Full text PDF
Research Paper Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer Full text PDF
Research Paper Functional Stratification and Long-Term Care Service Patterns among Discharged Patients with Cancer: A Retrospective Study from Taiwan Full text PDF
Issue 5; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Background: Thyroid nodules (TNs) are common, and accurate malignancy risk stratification is critical for clinical decision-making. Although serum thyroid biomarkers are routinely measured, their contribution to malignancy discrimination remains insufficiently characterized. Thus, we aimed to develop a practical and biologically grounded model for identifying malignant TNs using routinely clinical data. Methods: We retrospectively analyzed 5537 patients ...
Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains one of the leading contributors to cancer-related mortality worldwide, primarily due to the disease's therapeutic resistance and marked tumor heterogeneity. Among the molecular mechanisms implicated in HCC progression, the dysregulation of the JNK and PI3K/AKT signaling pathways plays a critical role in tumor initiation, cell proliferation, and cell ...