Impact Factor ISSN: 1837-9664
Global reach, higher impact
Research Paper Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients Full text PDF
Research Paper Exploratory Serum Metabolomics Identifies Metabolic Subgroups Across the Gastric Dysplasia-Early Cancer Spectrum Full text PDF
Review The Role of Traditional Chinese Medicine in Metabolic Reprogramming, Tumor microenvironment, and Macrophage Regulation: Mechanisms and Advances in Preclinical Studies Full text PDF
Research Paper Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender Full text PDF
Review Anticancer Effects of Cepharanthine: an Updated Minireview Full text PDF
Research Paper A squamous epithelial gene interaction perturbation network index for risk stratification in esophageal squamous cell carcinoma Full text PDF PubMed PMC
Issue 4; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Anticancer Effects of Cepharanthine: an Updated Minireview
Cepharanthine (CEP), a bisbenzylisoquinoline alkaloid, has a long history of clinical use in Japan for various diseases. Over the past few decades, it is potent anticancer activities have garnered significant attention. In this review shows CEP exhibits anti-cancer activity via diverse mechanisms: it induces programmed cell death via intrinsic mitochondrial pathways, extrinsic death receptor signaling, and endoplasmic reticulum stress. It also arrests ...
Objective: This study aims to systematically evaluate phenome-wide clinical factors contributing to radiation-induced toxicities (RITs) and provide evidence to identify acute RITs-associated risk factors for personalized radiation treatment stratification. Methods: Leveraging genome-wide association study data from 12,042 patients with prostate, head and neck, breast, or lung cancer, we conducted MR-PheWAS (phenome-wide association study integrated ...