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Volume 16 (12); 2025

Research Papers

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Association between Tooth Extraction 2 Weeks before Radiotherapy and Osteoradionecrosis in Patients with Advanced Oral and Oropharyngeal Cancer
Masatoshi Usubuchi, Seiki Kanemura, Atsushi Hozawa, Ichiro Tsuji
J. Cancer 2025; 16(12): 3567-3578. doi:10.7150/jca.97294
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Impact of Huisheng Oral Solution Combined with Immune Checkpoint Inhibitors and Chemotherapy in Patients with Stage III-IV Non-Small Cell Lung Cancer: A Retrospective Analysis
Yifeng Bai, Jirui Wang, Linsheng Song, Honglin Hu, Lan Yang, Gang Feng, Jie Chen, Heling Peng, Shengkun Peng
J. Cancer 2025; 16(12): 3579-3588. doi:10.7150/jca.116142
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LncRNA SNHG15 acts as a ceRNA to promote breast cancer progression through the miR-153-3p/KLF5 signal axis
Xu Zheng, Luyao Zhang, Ying Feng, Fan Zhu, Jiangming Shi, Yang Feng, Qian Chen, Ruizhi Shen
J. Cancer 2025; 16(12): 3589-3598. doi:10.7150/jca.116946
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Nomograms Combining Three Different Lymph Node Classifications to Predict the Survival of Tonsillar Squamous Cell Carcinoma Patients Undergoing Surgical Treatment
Dilong Yu, Zhuo Tan, Chuanming Zheng, Jiajie Xu, Ping Huang, Shiqin Hong, Qing Li, Yiwen Zhang, Minghua Ge
J. Cancer 2025; 16(12): 3599-3614. doi:10.7150/jca.98658
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Melittin inhibits osteosarcoma growth in vitro and in vivo by inactivating the Wnt/β-catenin signaling pathway
Xiaobo Wang, Junli Chang, Xingyuan Sun, Suxia Guo, Yimian Li, Qi Shi, Yanping Yang
J. Cancer 2025; 16(12): 3615-3628. doi:10.7150/jca.109750
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KDM6B enhances anti-PD-L1 immunotherapy efficacy by increasing CD8+ T-cell infiltration in colorectal cancer
Jing Xun, Zehan Liu, Bin Liu, Xiaolin Jiang, Huichao Yang, Jinjin Liu, Botao Wang, Ruifang Gao, Aimin Zhang, Xueliang Wu, Qing Xi, Xiangyang Yu, Qi Zhang
J. Cancer 2025; 16(12): 3629-3642. doi:10.7150/jca.118571
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Identifying an immunogenic cell death-related gene signature and HSPA6 infers adverse prognosis in acute myeloid leukemia
Ke Min, Chuanyang Lu, Xiaolu Wu, Shiyang Zhong, Ping Ma, Yu Zheng, Kai Xue, Qian Sun, Wenjie Liu, Chunling Wang, Liang Yu, Kening Li, Ming Hong, Ran Li
J. Cancer 2025; 16(12): 3643-3653. doi:10.7150/jca.115717
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Comparing Perioperative Outcomes of Robotic-Assisted Versus Laparoscopic Liver Resection in Patients with Hepatocellular Carcinoma
Xiao-Kun Huang, Lin-Lin Gan, Lei Liang, Kai Wang, Kai-Di Wang, Yang Yu, Zheng-Kang Fang, Yi Lu, Guo-Liang Shen, Dong-Sheng Huang, Cheng-Wu Zhang, Jun-Wei Liu, Jian Cheng
J. Cancer 2025; 16(12): 3664-3672. doi:10.7150/jca.115543
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Spermidine potentiates anti-tumor immune responses and immunotherapy sensitivity in breast cancer
Xinyu Yang, Yaxin Feng, Ruxin Wang, Xin Zeng, Boying Gao, Penghan Huang, Huiping Chen, Wenfeng Zeng
J. Cancer 2025; 16(12): 3684-3695. doi:10.7150/jca.113235
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Metformin May Improve Intestinal Mucosal Barrier Function and Help Prevent and Reverse Colorectal Cancer in Mice
Ruiqi Wang, Longke Xie, Ping Jiang, Yaping Hou, Dazhou Li, Wen Wang
J. Cancer 2025; 16(12): 3703-3711. doi:10.7150/jca.101251
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Pan-Cancer Analysis of GPR141: Unveiling its prognostic significance, immune microenvironment interactions, and therapeutic potential
Jingyue Sun, Sha Qin, Zisheng Li, Xin Peng, Desheng Xiao, Yongguang Tao, Bin Xie
J. Cancer 2025; 16(12): 3712-3728. doi:10.7150/jca.118222
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Cancer-associated Fibroblasts Confer Osimertinib Resistance in Non-small Cell Lung Cancer Cells via NRG1-mediated HER3/AKT Signaling
Sijia Zheng, Limin Cao, Jiayi Zhang, Qicheng Zhang, Yinghui Ren, Min Wang, Yongmei Qian, Bingbing Li, Xiang Wu, Zhaowei Meng, Ke Xu
J. Cancer 2025; 16(12): 3729-3745. doi:10.7150/jca.111383
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Symptoms and Outcomes in Colorectal Cancer Patients: A Saudi Tertiary Hospital's Five-Year Analysis
Abdossalam M. Madkhali, Mohammed A. Almozini, Hasah F. Alaluan, Mohammed M. Ahmed, Mohammed H. Alnajeim, Nada F. Alsaif, Shatha K. Bin Dher, Ahmed M. Alsultan, Tareq Salah
J. Cancer 2025; 16(12): 3746-3751. doi:10.7150/jca.116682
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Comprehensive analysis reveals MCM4 as a biomarker for guiding therapies and immunomodulatory role in skin cutaneous melanoma
Wei Ou, Jiang Zhou, Zhenhua Huang, XinLiang Yang, Xiaohong Liu, Wenjian Zuo, ZhiYong Luo, Min Su
J. Cancer 2025; 16(12): 3752-3766. doi:10.7150/jca.117471
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Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer
Wei-Chun Weng, Tien-Huang Lin, Xiu-Yuan He, Chia-Yen Lin, Hsi-Chin Wu, Yuan-Li Huang, Chao-Yang Lai, Chun-Hao Tsai, Yi-Chin Fong, Shun-Fa Yang, Chih-Hsin Tang
J. Cancer 2025; 16(12): 3767-3774. doi:10.7150/jca.119089
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The impact of long non-coding RNA HOTTIP genetic variants on oral cancer progression and clinicopathological characteristics
Ping-Ju Chen, Chiao-Wen Lin, Chun-Wen Su, Yung-Ching Wang, Heng-Hsiung Wu, Hsiao-Ju Chu, Shun-Fa Yang, Shih-Chi Su, Cheng-Chen Huang, Ying-Erh Chou
J. Cancer 2025; 16(12): 3775-3782. doi:10.7150/jca.117916
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Whole-transcriptome analysis reveals the interactions of mRNAs and ncRNAs to predict and validate ceRNA networks in osteosarcoma with lung metastases
KunPeng Zhu, XingKai Wang, Lin Fan, Jiao Sun, DePing Chen, Xiaojian He, ChunLin Zhang, ChuanZhen Hu
J. Cancer 2025; 16(12): 3783-3796. doi:10.7150/jca.118620
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Reviews

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From Spatial Patterns to Prognosis: Decoding Single-Cell Architecture in Cancer with Hyperplex Immunofluorescence Imaging
Mohammadreza Azimi
J. Cancer 2025; 16(12): 3654-3663. doi:10.7150/jca.115037
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SETD2 and EZH2: Two epigenetic drivers of prostate cancer
Jiamin Wang, Longquan Xiang, Haiyan Zhang, Xiangyu Zhang
J. Cancer 2025; 16(12): 3673-3683. doi:10.7150/jca.115715
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The biological function and research progress of the adipokine chemerin in tumorigenesis and development
Yongshuai Jiang, Yingying Wei, Ziyang Li, Junsheng Dong, Weijuan Gong
J. Cancer 2025; 16(12): 3696-3702. doi:10.7150/jca.117040
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