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Volume 12 (6); 2021

Research Papers

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Ageing as key factor for distant metastasis patterns and prognosis in patients with extensive-stage Small Cell Lung Cancer
Junyong Zou, Shijie Guo, Meng Ting Xiong, Yingchun Xu, Jiale Shao, Zhongkai Tong, Peng Zhang, Long Pan, Aimei Peng, Xuan Li
J. Cancer 2021; 12(6): 1575-1582. doi:10.7150/jca.49681
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Clinicopathological and prognostic significance of Fusobacterium nucleatum infection in colorectal cancer: a meta-analysis
Shu-chen Huangfu, Wen-bin Zhang, Hao-ran Zhang, Yang Li, Yi-ran Zhang, Jin-lin Nie, Xiao-dong Chu, Chang-shun Chen, Hai-ping Jiang, Jing-hua Pan
J. Cancer 2021; 12(6): 1583-1591. doi:10.7150/jca.50111
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of Cathepsin S Restores TGF-β-induced Epithelial-to-mesenchymal Transition and Tight Junction Turnover in Glioblastoma Cells
Li Wei, Naiyuan Shao, Ya Peng, Peng Zhou
J. Cancer 2021; 12(6): 1592-1603. doi:10.7150/jca.50631
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Machine learning classifiers for predicting 3-year progression-free survival and overall survival in patients with gliomas after surgery
Bin Zhang, Jing Yan, Weiqi Chen, Yuhao Dong, Lu Zhang, Xiaokai Mo, Qiuying Chen, Jingliang Cheng, Xianzhi Liu, Weiwei Wang, Zhenyu Zhang, Shuixing Zhang
J. Cancer 2021; 12(6): 1604-1615. doi:10.7150/jca.52183
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The correlation between tumor size, lymph node status, distant metastases and mortality in rectal cancer patients without neoadjuvant therapy
Dakui Luo, Zezhi Shan, Qi Liu, Sanjun Cai, Yanlei Ma, Qingguo Li, Xinxiang Li
J. Cancer 2021; 12(6): 1616-1622. doi:10.7150/jca.52165
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cartilage oligomeric matrix protein affects the biological behavior of papillary thyroid carcinoma cells by activating the PI3K/AKT/Bcl-2 pathway
Jirong Zhang, Hongzhi Wang, Chunpeng Lv, Jun Han, Mingyu Hao, Jingjing Li, Hong Qiao
J. Cancer 2021; 12(6): 1623-1633. doi:10.7150/jca.49144
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DNA methylation integratedly modulates the expression of Pit-Oct-Unt transcription factors in esophageal squamous cell carcinoma
Wei He, Shuai Gong, Xin Wang, Xinhua Dong, Hua Cheng
J. Cancer 2021; 12(6): 1634-1643. doi:10.7150/jca.49231
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Value of Multi-targeted Fecal DNA Methylation Detection for Colorectal Cancer Screening in a Chinese Population
Heiying Jin, Jun Wang, Chunxia Zhang
J. Cancer 2021; 12(6): 1644-1650. doi:10.7150/jca.47214
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identifying Potential Markers for Monitoring Progression to Ovarian Cancer Using Plasma Label-free Proteomics
Wenjie Wang, Hongyu Xie, Bairong Xia, Liuchao Zhang, Yan Hou, Kang Li
J. Cancer 2021; 12(6): 1651-1659. doi:10.7150/jca.50733
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
Yinglei Liu, Boqun Xu, Manhua Liu, Haifeng Qiao, Siming Zhang, Junjun Qiu, Xiaoyan Ying
J. Cancer 2021; 12(6): 1660-1668. doi:10.7150/jca.47344
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Histologic Lymph Nodes Regression after Preoperative Chemotherapy as Prognostic Factor in Non-metastatic Advanced Gastric Adenocarcinoma
Augustinas Bausys, Veslava Senina, Martynas Luksta, Giedre Anglickiene, Greta Molnikaite, Bernardas Bausys, Andrius Rybakovas, Edita Baltruskeviciene, Arvydas Laurinavicius, Tomas Poskus, Rimantas Bausys, Dmitrij Seinin, Kestutis Strupas
J. Cancer 2021; 12(6): 1669-1677. doi:10.7150/jca.49673
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
Wei Zhang, Gang Wu, Peichun Sun, Yuanzeng Zhu, Han Zhang
J. Cancer 2021; 12(6): 1678-1686. doi:10.7150/jca.50888
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Efficacy of second-line treatments for patients with advanced human epidermal growth factor receptor 2 positive breast cancer after trastuzumab-based treatment: a systematic review and bayesian network analysis
Fei Chen, Naifei Chen, Zheng Lv, Lingyu Li, Jiuwei Cui
J. Cancer 2021; 12(6): 1687-1697. doi:10.7150/jca.51845
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Expression of PD1/PDL1 in gastric cancer at different microsatellite status and its correlation with infiltrating immune cells in the tumor microenvironment
Yan-li Wang, Yuehua Gong, Zhi Lv, Liang Li, Yuan Yuan
J. Cancer 2021; 12(6): 1698-1707. doi:10.7150/jca.40500
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Segmentectomy or Wedge Resection in Stage IA Lung Squamous Cell Carcinoma and Adenocarcinoma?
Guoshu Li, Shuanshuan Xie, Feng Hu, Min Tan, Lihong Fan, Changhui Wang
J. Cancer 2021; 12(6): 1708-1714. doi:10.7150/jca.49683
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Clinical significance of site-specific metastases in pancreatic cancer: a study based on both clinical trial and real-world data
Lixia Wu, Lina Zhu, Kequn Xu, Siyuan Zhou, Yang Zhou, Tiening Zhang, Junjie Hang, Benny Chung-Ying Zee
J. Cancer 2021; 12(6): 1715-1721. doi:10.7150/jca.50317
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry
Qiaoli Zheng, Xianzhen chen, Rui Han, Jiang Zhu, Hui Wang, Lingjing Chen, Yinjing Song, Luxia Chen, Hao Cheng, Na Jin
J. Cancer 2021; 12(6): 1722-1728. doi:10.7150/jca.50816
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Preliminary study on SPECT/CT imaging of pancreatic cancer xenografts by targeting integrin α5 in pancreatic stellate cells
Tao Wang, Ye Peng, Rou Li, Xiao Li, Changjing Zuo
J. Cancer 2021; 12(6): 1729-1733. doi:10.7150/jca.51190
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Para-aortic lymph node metastasis in lower Thoracic Esophageal Squamous Cell Carcinoma after Radical Esophagectomy: a CT-based atlas and its clinical implications for Adjuvant Radiotherapy
Luxi Ye, Lijun Zhou, Shengping Wang, Lining Sun, Jiazhou Wang, Quan Liu, Xi Yang, Li Chu, Xiaofei Zhang, Weigang Hu, Jie Lin, Zhengfei Zhu
J. Cancer 2021; 12(6): 1734-1741. doi:10.7150/jca.51212
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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AURKA and FAM83A are prognostic biomarkers and correlated with Tumor-infiltrating Lymphocytes in smoking related Lung Adenocarcinoma
Mengyu Zhang, Chen Huo, Yingxiao Jiang, Jianyu Liu, Yican Yang, Yunhong Yin, Yiqing Qu
J. Cancer 2021; 12(6): 1742-1754. doi:10.7150/jca.51321
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LINC00665 promotes Ovarian Cancer progression through regulating the miRNA-34a-5p/E2F3 axis
Dan Xu, Qingxia Song, Ying Liu, Wansu Chen, Lijuan LU, Min Xu, Xiaohui Fang, Wenjie Zhao, Huifang Zhou
J. Cancer 2021; 12(6): 1755-1763. doi:10.7150/jca.51457
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The clinical value of indocyanine green fluorescence navigation system for laparoscopic partial nephrectomy in the case of complex renal clear cell carcinoma (R.E.N.A.L score ≥7)
Rongjiang Wang, Jianer Tang, Yu Chen, Zhihai Fang, Junwen Shen
J. Cancer 2021; 12(6): 1764-1769. doi:10.7150/jca.55033
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Preoperative Portal Vein Embolization for Liver Resection: An updated meta-analysis
Yu Huang, Wenhao Ge, Yang Kong, Yuan Ding, Bingqiang Gao, Xiaohui Qian, Weilin Wang
J. Cancer 2021; 12(6): 1770-1778. doi:10.7150/jca.50371
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of Potential BRAF Inhibitor Joint Therapy Targets in PTC based on WGCAN and DCGA
YaLi Han, XiaQing Yu, YuZhen Yin, Zhongwei Lv, ChengYou Jia, Yina Liao, Hongyan Sun, Tie Liu, Lele Cong, ZhaoLiang Fei, Da Fu, Xianling Cong, Shen Qu
J. Cancer 2021; 12(6): 1779-1791. doi:10.7150/jca.51551
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Transcription factor E2F4 is an indicator of poor prognosis and is related to immune infiltration in hepatocellular carcinoma
Qiuxian Zheng, Qiang Fu, Jia Xu, Xinyu Gu, Haibo Zhou, Chen Zhi
J. Cancer 2021; 12(6): 1792-1803. doi:10.7150/jca.51616
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner
Yanfang Li, Sha Li, Yizhou Zhang, Shuhong Shi, Shan Qin, Chang Wang, Juan Du, Jingle Ma, Huan Chen, Huixian Cui
J. Cancer 2021; 12(6): 1815-1825. doi:10.7150/jca.51099
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Overexpression of HIPK2 removes the transrepression of proapoptotic genes mediated by the CtBP1-p300-FOXO3a complex and increases the chemosensitivity in osteosarcoma cells
Ning Duan, Wentao Zhang, Zhong Li, Liang Sun, Tao Song, Zirui Yu, Xun Chen, Wei Ma
J. Cancer 2021; 12(6): 1826-1837. doi:10.7150/jca.52115
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Study on the correlation between Helicobacter Pylori and biological characteristics of early Gastric Cancer
Guanqun Chao, Xinli Chen, Shuo Zhang
J. Cancer 2021; 12(6): 1838-1845. doi:10.7150/jca.46392
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combination of oncolytic adenovirus targeting SATB1 and docetaxel for the treatment of castration-resistant prostate cancer
Lijun Mao, Haiyuan Yu, Sai Ma, Ziyang Xu, Fukun Wei, Chunhua Yang, Junnian Zheng
J. Cancer 2021; 12(6): 1846-1852. doi:10.7150/jca.46868
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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CAR-T cells for Colorectal Cancer: Target-selection and strategies for improved activity and safety
Huali Li, Chao Yang, Huangrong Cheng, Shuoyang Huang, Yongbin Zheng
J. Cancer 2021; 12(6): 1804-1814. doi:10.7150/jca.50509
[Abstract] [Full text] [PDF] [PubMed] [PMC]