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Volume 11 (12); 2020

Research Papers

The LncRNA HOTAIRM1 Promotes Tamoxifen Resistance by Mediating HOXA1 Expression in ER+ Breast Cancer Cells
Clara Yuri Kim, Ji Hoon Oh, Ji-Yeon Lee, Myoung Hee Kim
J. Cancer 2020; 11(12): 3416-3423. doi:10.7150/jca.38728
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiR-425 Promotes Migration and Invasion in Bladder Cancer by Targeting Dickkopf 3
Jin-zhuo Ning, Wei-min Yu, Fan Cheng, Ting Rao, Yuan Ruan
J. Cancer 2020; 11(12): 3424-3432. doi:10.7150/jca.40233
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer
Ru Bai, Kaikai Dou, Yang Wu, Yongjing Ma, Jianmin Sun
J. Cancer 2020; 11(12): 3433-3445. doi:10.7150/jca.40604
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiR-186 bidirectionally regulates cisplatin sensitivity of ovarian cancer cells via suppressing targets PIK3R3 and PTEN and upregulating APAF1 expression
Ying Xiang, Ya-Jun Chen, Yun-Bo Yan, Yu Liu, Jiao Qiu, Rui-Qiao Tan, Qing Tian, Li Guan, Shuai-Shuai Niu, Hong-Wu Xin
J. Cancer 2020; 11(12): 3446-3453. doi:10.7150/jca.41135
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
Fugen Shangguan, Yan Liu, Li Ma, Guiwu Qu, Qing Lv, Jing An, Shude Yang, Bin Lu, Qizhi Cao
J. Cancer 2020; 11(12): 3454-3466. doi:10.7150/jca.41418
[Abstract] [Full text] [PDF] [PubMed] [PMC]

PLOD2 increases resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis
Xiaohui Wang, Jiaojiao Guo, Meng Dai, Tengqi Wang, Tingting Yang, Xuejun Xiao, Qi Tang, Lingli Zhang, Lizhou Jia
J. Cancer 2020; 11(12): 3467-3475. doi:10.7150/jca.41828
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
Xiao-Jian Liu, Li-Na Wang, Zu-Han Zhang, Cong Liang, Yu Li, Jie-Si Luo, Chun-Jin Peng, Xiao-Li Zhang, Zhi-Yong Ke, Li-Bin Huang, Yan-Lai Tang, Xue-Qun Luo
J. Cancer 2020; 11(12): 3476-3482. doi:10.7150/jca.29751
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Multicenter Validation Study of the American Joint Commission on Cancer (8th Edition) for Gastric Cancer: Proposal for a Simplified and Improved TNM Staging System
Jian-Xian Lin, Jacopo Desiderio, Jun-Peng Lin, Wei Wang, Ru-Hong Tu, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Chao-Hui Zheng, Zhi-wei Zhou, Amilcare Parisi, Chang-Ming Huang
J. Cancer 2020; 11(12): 3483-3491. doi:10.7150/jca.36891
[Abstract] [Full text] [PDF] [PubMed] [PMC]

lncRNA SNHG3 acts as a novel Tumor Suppressor and regulates Tumor Proliferation and Metastasis via AKT/mTOR/ERK pathway in Papillary Thyroid Carcinoma
Yu Duan, Zhiyong Wang, Lijuan Xu, Li Sun, Hairong Song, Huiqing Yin, Fucheng He
J. Cancer 2020; 11(12): 3492-3501. doi:10.7150/jca.42070
[Abstract] [Full text] [PDF] [PubMed] [PMC]

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children
Zhonghua Yang, Yuyao Deng, Keren Zhang, Yuzuo Bai, Jinhong Zhu, Jiao Zhang, Yijuan Xin, Li Li, Jing He, Weilin Wang
J. Cancer 2020; 11(12): 3512-3518. doi:10.7150/jca.42798
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Neoadjuvant chemoradiotherapy or radiotherapy in patients aged 75 years or older with locally advanced rectal cancer
Xiaoliang Liu, Junjie Wang, Ke Hu, Fuquan Zhang, Xiaorong Hou, Yi Xiao, Xin Lian, Shuai Sun, Zhikai Liu, Junfang Yan, Zheng Miao
J. Cancer 2020; 11(12): 3536-3542. doi:10.7150/jca.41950
[Abstract] [Full text] [PDF] [PubMed] [PMC]

RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients
Qian Li, Helen J Huang, Jing Ma, Yafei Wang, Zeng Cao, George Karlin-Neumann, Filip Janku, Zhiqiang Liu
J. Cancer 2020; 11(12): 3543-3550. doi:10.7150/jca.43729
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Prognostic Value of ANXA8 in Gastric Carcinoma
Fangqi Ma, Xiaowei Li, Haiming Fang, Yueping Jin, Qin Sun, Xuejun Li
J. Cancer 2020; 11(12): 3551-3558. doi:10.7150/jca.40010
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Optimal timing of antiviral therapy for patients with malignant tumor who presented with hepatitis B reactivation during chemotherapy and/or immunosuppressive therapy
Xiaofang Zou, Longhua Guo, Yinfang Gu, Zhijun Yang, Ping Huang, Tianhuang Liu, Jingjing Zhao, Guowu Wu
J. Cancer 2020; 11(12): 3559-3566. doi:10.7150/jca.40154
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Surgery on primary tumor shows survival benefit in selected stage IV colon cancer patients: A real-world study based on SEER database
Jing Xu, Tai Ma, Yuanzi Ye, Zhipeng Pan, Donghui Lu, Faming Pan, Wanren Peng, Guoping Sun
J. Cancer 2020; 11(12): 3567-3579. doi:10.7150/jca.43518
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer
Shu-Qin Li, Yang Yu, Yan Zhang, Yan-Ping Sun, Xin-xing Li, Ning Su
J. Cancer 2020; 11(12): 3580-3587. doi:10.7150/jca.36355
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation
Yan Yuan, Yang Du, Lei Wang, Xiuheng Liu
J. Cancer 2020; 11(12): 3588-3595. doi:10.7150/jca.42338
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Determination of the Expression of PD-L1 in the Morphologic Spectrum of Renal Cell Carcinoma
Beatriz Walter, Sara Gil, Xu Naizhen, Michael J Kruhlak, W Marston Linehan, Ramaprasad Srinivasan, Maria J Merino
J. Cancer 2020; 11(12): 3596-3603. doi:10.7150/jca.35738
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3
Jia Wei Zhang, Xing Wang, Gao Chao Li, Dong Wang, Sheng Han, Yao Dong Zhang, Chen Huan Luo, Hong Wei Wang, Wang Jie Jiang, Chang Xian Li, Xiang Cheng Li
J. Cancer 2020; 11(12): 3604-3614. doi:10.7150/jca.41437
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation
Shaojie Jiang, Fei Zhou, Yanhua Zhang, Weiping Zhou, Linghua Zhu, Miaofeng Zhang, Jingfeng Luo, Rui Ma, Xiufang Xu, Jiying Zhu, Xue Dong, Shuangling Zhang, Jie Fang, Jihong Sun, Xiaoming Yang
J. Cancer 2020; 11(12): 3623-3633. doi:10.7150/jca.37393
[Abstract] [Full text] [PDF] [PubMed] [PMC]

miR-365a-3p regulates ADAM10-JAK-STAT signaling to suppress the growth and metastasis of colorectal cancer cells
Yong-gang Hong, Cheng Xin, Hao Zheng, Zhi-ping Huang, Yuan Yang, Ji-dian Zhou, Xian-hua Gao, Lun Hao, Qi-zhi Liu, Wei Zhang, Li-qiang Hao
J. Cancer 2020; 11(12): 3634-3644. doi:10.7150/jca.42731
[Abstract] [Full text] [PDF] [PubMed] [PMC]

LncRNA NONHSAT141924 promotes paclitaxel chemotherapy resistance through p-CREB/Bcl-2 apoptosis signaling pathway in breast cancer
Ming Gu, Wenhui Zheng, Mingdi Zhang, Xiaoshen Dong, Yan Zhao, Shuo Wang, Haiyang Jiang, Xinyu Zheng
J. Cancer 2020; 11(12): 3645-3654. doi:10.7150/jca.39463
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway
Huan Liu, Xiaobao Gong, Kai Yang
J. Cancer 2020; 11(12): 3655-3666. doi:10.7150/jca.42771
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Cyclooxygenase-2 mediates gefitinib resistance in non-small cell lung cancer through the EGFR/PI3K/AKT axis
Qin-fang Deng, Qi-yu Fang, Xian-Xiu Ji, Song-wen Zhou
J. Cancer 2020; 11(12): 3667-3674. doi:10.7150/jca.42850
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Down-regulated Solute Carrier Family 4 Member 4 Predicts Poor Progression in Colorectal Cancer
Hong Yang, Yao Lu, Weilan Lan, Bin Huang, Jiumao Lin
J. Cancer 2020; 11(12): 3675-3684. doi:10.7150/jca.36696
[Abstract] [Full text] [PDF] [PubMed] [PMC]

A2AR Antagonism with DZD2269 Augments Antitumor Efficacy of Irradiation in Murine Model
Jiaqi Huang, Di Zhang, Yu Bai, Pamela Yang, Ligang Xing, Jinming Yu
J. Cancer 2020; 11(12): 3685-3692. doi:10.7150/jca.43966
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Risk Factors Associated with Esophageal Fistula after Radiotherapy for Esophageal Squamous Cell Carcinoma
Bing Hu, Feng Jia, Haiyan Zhou, Tao Zhou, Qian Zhao, Yiru Chen, Baosheng Li, Wei Huang
J. Cancer 2020; 11(12): 3693-3700. doi:10.7150/jca.39033
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors
Yingying Che, Lin Fu
J. Cancer 2020; 11(12): 3502-3511. doi:10.7150/jca.42645
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases
Hongjiao Xiang, Yifei Lu, Mingmei Shao, Tao Wu
J. Cancer 2020; 11(12): 3519-3535. doi:10.7150/jca.41841
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Deep Learning Model as a New Trend in Computer-aided Diagnosis of Tumor Pathology for Lung Cancer
Lei Cong, Wanbing Feng, Zhigang Yao, Xiaoming Zhou, Wei Xiao
J. Cancer 2020; 11(12): 3615-3622. doi:10.7150/jca.43268
[Abstract] [Full text] [PDF] [PubMed] [PMC]