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Volume 11 (13); 2020

Research Papers

Metformin in combination with JS-K inhibits growth of renal cell carcinoma cells via reactive oxygen species activation and inducing DNA breaks
Yuwan Zhao, Qiuming Luo, Jierong Mo, Jianwei Li, Dongcai Ye, Zhixian Ao, Lixin Chen, Jianjun Liu
J. Cancer 2020; 11(13): 3701-3712. doi:10.7150/jca.36372
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells
Muhammad Khan, Amara Maryam, Muhammad Zubair Saleem, Hafiz Abdullah Shakir, Javed Iqbal Qazi, Yongming Li, Tonghui Ma
J. Cancer 2020; 11(13): 3725-3735. doi:10.7150/jca.40983
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway
Yan Wang, Rongrong Yao, Danying Zhang, Rongxin Chen, Zhenggang Ren, Lan Zhang
J. Cancer 2020; 11(13): 3736-3744. doi:10.7150/jca.42953
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Delayed post-diuretic 18F-FDG PET/CT for preoperative evaluation of renal pelvic cancer
Yiping Shi, Ruohua Chen, Yining Wang, Gan Huang, Qian Xia, Jianjun Liu
J. Cancer 2020; 11(13): 3745-3750. doi:10.7150/jca.44512
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Improved Prognostic Prediction of Glioblastoma using a PAS Detected from Single-cell RNA-seq
Hongwei Liu, Qi Yang, Yi Xiong, Zujian Xiong, Xuejun Li
J. Cancer 2020; 11(13): 3751-3761. doi:10.7150/jca.44034
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CMTM5-v1 inhibits cell proliferation and migration by downregulating oncogenic EGFR signaling in prostate cancer cells
Yeqing Yuan, Zhengzuo Sheng, Zhenhua Liu, Xiaowei Zhang, Yunbei Xiao, Jing Xie, Yixiang Zhang, Tao Xu
J. Cancer 2020; 11(13): 3762-3770. doi:10.7150/jca.42314
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiR-891a-5p as a prognostic marker and therapeutic target for hormone receptor-positive breast cancer
Zhiqiang Zhang, Lu Xu, Lijie He, Jin Wang, Xiaonan Shi, Zhi Li, Sha Shi, Kezuo Hou, Yuee Teng, Xiujuan Qu
J. Cancer 2020; 11(13): 3771-3782. doi:10.7150/jca.40750
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Analysis of Differentially Expressed Genes in a Chinese Cohort of Esophageal Squamous Cell Carcinoma
Gang Liu, Yuan Zhao, Huili Chen, Jinru Jia, Xiaomin Cheng, Fengjie Wang, Qiang Ji, Rick F. Thorne, Song Chen, Xiaoying Liu
J. Cancer 2020; 11(13): 3783-3793. doi:10.7150/jca.40850
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Integrating Genomic Data with Transcriptomic Data for Improved Survival Prediction for Adult Diffuse Glioma
Qi Yang, Yi Xiong, Nian Jiang, Fanyuan Zeng, Chunhai Huang, Xuejun Li
J. Cancer 2020; 11(13): 3794-3802. doi:10.7150/jca.44032
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1
Mingliang Zhou, Jun Niu, Jinshen Wang, Huijie Gao, Muhammad Shahbaz, Zhengchuan Niu, Zequn Li, Xueqing Zou, Benjia Liang
J. Cancer 2020; 11(13): 3803-3815. doi:10.7150/jca.43826
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines
Chunjie Wen, Ge Xu, Shuai He, Yutang Huang, Jingjing Shi, Lanxiang Wu, Honghao Zhou
J. Cancer 2020; 11(13): 3816-3826. doi:10.7150/jca.39783
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Prevalence and characteristics of PIK3CA mutation in mismatch repair-deficient colorectal cancer
Weihua Li, Tian Qiu, Lin Dong, Fanshuang Zhang, Lei Guo, Jianming Ying
J. Cancer 2020; 11(13): 3827-3833. doi:10.7150/jca.37437
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood
Yalun Li, Huizhe Wu, Chengzhong Xing, Xiaoyun Hu, Fangxiao Zhang, Yangjie Peng, Zeyu Li, Tingting Lu
J. Cancer 2020; 11(13): 3834-3845. doi:10.7150/jca.42409
[Abstract] [Full text] [PDF] [PubMed] [PMC]

ID4 Promotes Breast Cancer Chemotherapy Resistance via CBF1-MRP1 Pathway
Xi Zhang, Guangyan Gu, Lin Song, Dan Wang, Yali Xu, Shuping Yang, Bin Xu, Zhixin Cao, Chunmei Liu, Chunming Zhao, Yuanyuan Zong, Yejun Qin, Jiawen Xu
J. Cancer 2020; 11(13): 3846-3857. doi:10.7150/jca.31988
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration
Pan Wang, Xinyu Zhang, Nan Sun, Zhihong Zhao, Jie He
J. Cancer 2020; 11(13): 3858-3870. doi:10.7150/jca.44413
[Abstract] [Full text] [PDF] [PubMed] [PMC]

miR-93-5p enhances migration and invasion by targeting RGMB in squamous cell carcinoma of the head and neck
Shuiting Zhang, Yanjuan He, Chao Liu, Guo Li, Shanhong Lu, Qiancheng Jing, Xiyu Chen, Huiling Ma, Diekuo Zhang, Yunyun Wang, Donghai Huang, Pingqing Tan, Jie Chen, Xin Zhang, Yong Liu, Yuanzheng Qiu
J. Cancer 2020; 11(13): 3871-3881. doi:10.7150/jca.43854
[Abstract] [Full text] [PDF] [PubMed] [PMC]

LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathway
Qingqiang Dai, Tianqi Zhang, Jiaomeng Pan, Chen Li
J. Cancer 2020; 11(13): 3882-3892. doi:10.7150/jca.43446
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells
Yang Song, Xuejing Zou, Dongyan Zhang, Shanshan Liu, Zhijiao Duan, Li Liu
J. Cancer 2020; 11(13): 3893-3902. doi:10.7150/jca.42944
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Can Combined Screening of Ultrasound and Elastography Improve Breast Cancer Identification Compared with MRI in Women with Dense Breasts-a Multicenter Prospective Study
Lu-Ying Gao, Yang Gu, Wen Xu, Jia-Wei Tian, Li-Xue Yin, Hai-Tao Ran, Wei-Dong Ren, Yu-Ming Mu, Jie-Ying Zhang, Cai Chang, Jian-Jun Yuan, Chun-Song Kang, You-Bin Deng, Hui Wang, Xiao-Yan Xie, Bao-Ming Luo, Sheng-Lan Guo, Qi Zhou, En-Sheng Xue, Wei-Wei Zhan, Tong Jiao, Qing Zhou, Jie Li, Ping Zhou, Pin-Tong Huang, Hong-Yuan Xue, Chun-Quan Zhang, Man Chen, Xiang-Xiang Jing, Ying Gu, Jian-Feng Guo, Hong-Yu Ding, Jin-Feng Xu, Wu Chen, Li Liu, Yu-Hong Zhang, Hong-Qiao Wang, Zhong-Ping Mu, Jian-Chu Li, Hong-Yan Wang, Yu-Xin Jiang
J. Cancer 2020; 11(13): 3903-3909. doi:10.7150/jca.43326
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
Rui Liu, Minghui Zhou, Puwen Zhang, Yulin Zhao, Yujie Zhang
J. Cancer 2020; 11(13): 3910-3918. doi:10.7150/jca.42799
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Sonic Hedgehog/Gli1 Signaling Pathway Regulates Cell Migration and Invasion via Induction of Epithelial-to-mesenchymal Transition in Gastric Cancer
Bin Ke, Xiao-Na Wang, Ning Liu, Bin Li, Xue-Jun Wang, Ru-Peng Zhang, Han Liang
J. Cancer 2020; 11(13): 3932-3943. doi:10.7150/jca.42900
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Untargeted Metabolomics Analysis of Esophageal Squamous Cell Carcinoma Discovers Dysregulated Metabolic Pathways and Potential Diagnostic Biomarkers
Zi-Jia Zhu, Zheng Qi, Ji Zhang, Wen-Hua Xue, Li-Feng Li, Zhi-Bo Shen, Ze-Yun Li, Yong-Liang Yuan, Wen-Bin Wang, Jie Zhao
J. Cancer 2020; 11(13): 3944-3954. doi:10.7150/jca.41733
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-κB
Ting Xu, Pu Guo, Chao Pi, Yingmeng He, Hongru Yang, Yi Hou, Xianhu Feng, Qingsheng Jiang, Yumeng Wei, Ling Zhao
J. Cancer 2020; 11(13): 3955-3964. doi:10.7150/jca.41783
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Prognostic significance of age related genes in patients with lower grade glioma
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao
J. Cancer 2020; 11(13): 3986-3999. doi:10.7150/jca.41123
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Diagnostic Yield and Performance of a Large Population-Based Cervical Cancer Screening Program in High-Risk Rural China
Zhilian Wang, Tiannan Wang, Jing Yang, Wei Wang, Lili Zhang, Xiaoqiang Su, Zhe Wang, Haitao Zhang, Jinghui Song, Weiguo Lv, Jintao Wang, Chen Wang, Chengquan Zhao, Min Hao
J. Cancer 2020; 11(13): 4000-4006. doi:10.7150/jca.41472
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

DNT Cell-based Immunotherapy: Progress and Applications
Yingrui Li, Kang Dong, Xueke Fan, Jun Xie, Miao Wang, Songtao Fu, Qin Li
J. Cancer 2020; 11(13): 3717-3724. doi:10.7150/jca.39717
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Cancer of Unknown Primary Site: Real Entity or Misdiagnosed Disease?
Alaa T. Alshareeda, Batla S. Al-Sowayan, Reem R. Alkharji, Sahar M. Aldosari, Abdullah M. Al subayyil, Ayidah Alghuwainem
J. Cancer 2020; 11(13): 3919-3931. doi:10.7150/jca.42880
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The role and function of PPARγ in bladder cancer
Tianchen Peng, Gang Wang, Songtao Cheng, Yaoyi Xiong, Rui Cao, Kaiyu Qian, Lingao Ju, Xinghuan Wang, Yu Xiao
J. Cancer 2020; 11(13): 3965-3975. doi:10.7150/jca.42663
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma
Yutong Tian, Lu Tang, Pin Yi, Qing Pan, Yaqian Han, Yingrui Shi, Shan Rao, Shiming Tan, Longzheng Xia, Jinguan Lin, Linda Oyang, Yanyan Tang, Jiaxin Liang, Xia Luo, Qianjin Liao, Hui Wang, Yujuan Zhou
J. Cancer 2020; 11(13): 3976-3985. doi:10.7150/jca.42734
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Paper

Reversal of HER2 Negativity: An Unexpected Role for Lovastatin in Triple-Negative Breast Cancer Stem Cells
Huimei Yi, Mi Wu, Qiuting Zhang, Lu Lu, Hui Yao, Sisi Chen, Ying Li, Chanjuan Zheng, Guangchun He, Xiyun Deng
J. Cancer 2020; 11(13): 3713-3716. doi:10.7150/jca.39265
[Abstract] [Full text] [PDF] [PubMed] [PMC]