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Volume 16 (1); 2025

Research Papers

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Impact of ALDH1A1 Expression in Intrahepatic Cholangiocellular Carcinoma Konrad Kurowski, Melanie Föll, Tilman Werner, Oliver Schilling, Martin Werner, Stefan Fichtner-Feigl, Bertram Bengsch, Peter Bronsert, Philipp Anton Holzner, Sylvia Timme J. Cancer 2025; 16(1): 1-11. doi:10.7150/jca.99944 Full text PDF PubMed PMC


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Pharmacological Profiling of Calotropis Procera and Rhazya Stricta: Unraveling the Antibacterial and Anti-Cancer Potential of Chemically Active Metabolites Sahar S. Alghamdi, Allulu Y. Alturki, Rizwan Ali, Rasha S. Suliman, Afrah E. Mohammed, Atheer Al Dairem, Zeyad I. Alehaideb, Raghad A. Alshafi, Sara A. Alghashem, Ishrat Rahman J. Cancer 2025; 16(1): 12-33. doi:10.7150/jca.96848 Full text PDF PubMed PMC


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Raddeanin A (RA) Inhibited EMT and Stemness in Glioblastoma via downregulating Skp2 Weiqiang Jia, Yanling Zhang, Qiang Zhao, Min Gong, Yang Cao, Jia Liu, Shuang Luo J. Cancer 2025; 16(1): 44-54. doi:10.7150/jca.95266 Full text PDF PubMed PMC


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MiR-675 Inhibits Primary Ovarian Tumor Growth and Metastasis by Suppressing EMT and TGFβ Signaling Xinxin Zhao, Ziping Liu, Yongshuai Li, Shiji Song, Baojin Wang, Lawrence M. Pfeffer, Wenjing Zhang, Junming Yue J. Cancer 2025; 16(1): 55-65. doi:10.7150/jca.102654 Full text PDF PubMed PMC


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Exploring the Role of Thioredoxin system in Cancer Immunotherapy Lin Sun, Anni Yu, Yang Yang, Zhiruo Wang, Wenqian Wang, Lan Luo J. Cancer 2025; 16(1): 66-80. doi:10.7150/jca.98306 Full text PDF PubMed PMC


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Identification of the oncogenic role and clinical implication of LZTS3 in Colon Adenocarcinoma Kui Ye, Huaxiang Cao, Zihao Xu, Peng Liu, Xueying Jiang, Qiancheng Liu, Hongquan Yang, Menghua Huo, Teng Wang, Jian Wang J. Cancer 2025; 16(1): 81-91. doi:10.7150/jca.102204 Full text PDF PubMed PMC


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Screening of Hub Genes and Therapeutic Drugs in Cervical Cancer Using Integrated Bioinformatics Analysis Ziruo Talihati, Kayisaier Abudurousuli, Sendaer Hailati, Mengyuan Han, Muhadaisi Nuer, Nawaz Khan, Nulibiya Maihemuti, Jimilihan Simayi, Weiyi Zhang, Wenting Zhou J. Cancer 2025; 16(1): 92-109. doi:10.7150/jca.87027 Full text PDF PubMed PMC


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Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells Jinglin Fang, Ruirui Wang, Xiaoying Li, XiaoCong Wang, Lingling Gong, An Lou, Jie Lu, Xiaoyue Zhang, Qin Zhao, Xinfang Yu, Qiling Zhou, Ming Li J. Cancer 2025; 16(1): 110-121. doi:10.7150/jca.100631 Full text PDF PubMed PMC


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Pan-cancer analyses reveal cancer-type-specific autophagy signatures with potential implications for prognosis and therapy response Hongyan Yuan, Xiaojing Zhu, Jiaxing Zhang, Zixin Zhang, Weihua Li, Jiankai Xu J. Cancer 2025; 16(1): 122-134. doi:10.7150/jca.101046 Full text PDF PubMed PMC


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The effect of intraoperative radiotherapy in musculoskeletal malignancy: A population study from US SEER database Yao Xu, Zhe Feng, YongHeng Liu, JinYan Feng, Yan Zhang, Chao Zhang, XiuXin Han, LiMing Xu, GuoWen Wang J. Cancer 2025; 16(1): 135-145. doi:10.7150/jca.100678 Full text PDF PubMed PMC


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Causal inference between immune cells and glioblastoma: a bidirectional Mendelian randomization study Shiqiang Hou, Chunjing Jin, Beitian Shi, Yinan Chen, Ning Lin J. Cancer 2025; 16(1): 171-181. doi:10.7150/jca.100519 Full text PDF PubMed PMC


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Deciphering the Prognostic Landscape of Esophageal Adenocarcinoma: A PANoptosis-Related Gene Signature Haijing Fu, Mengyan Liu, Huiyu Li, Li Yu, Haizhu Song, Xiaoyuan Chu, Wei Bao J. Cancer 2025; 16(1): 183-200. doi:10.7150/jca.102180 Full text PDF PubMed PMC


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Unveiling the Prognostic Power and Immune Landscape of MyD88 in Breast Cancer: an Integrative Bioinformatics and IHC Approach Xin Yu, Qinfang Zhang, Bei Li, Shengrong Sun, Juanjuan Li, Wenge Li J. Cancer 2025; 16(1): 201-213. doi:10.7150/jca.103403 Full text PDF PubMed PMC


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Knockdown of HOXD13 in Oral Squamous Cell Carcinoma Inhibited its Proliferation, Migration, and Influenced Fatty Acid Metabolism Xingyue Ma, Xiao Zhang, Haiyang Li, Shuang Mei, Bowen Wang, Shuai Guan, Yitong Wang, Yuantao Li, Siyi Li, Xiangjun Li J. Cancer 2025; 16(1): 214-226. doi:10.7150/jca.102100 Full text PDF PubMed PMC


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Demethylzeylasteral inhibits oxidative phosphorylation complex biogenesis by targeting LRPPRC in lung cancer Lina Wang, Wei Zhou, Wenxi Wang, Yuxin Liang, Qiqi Xue, Zhen Zhang, Jinghe Yuan, Xiaohong Fang J. Cancer 2025; 16(1): 227-240. doi:10.7150/jca.92797 Full text PDF PubMed PMC


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Metabolomics-based combination of GH and NVB in the treatment of NSCLC lung cancer recurrence Xinxin Li, Fengfei Chen, Rui Yang, Zhaohui Song, Xiaohui Ma, Li Sun, Shengtao Yuan J. Cancer 2025; 16(1): 265-278. doi:10.7150/jca.102722 Full text PDF PubMed PMC


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Analysis of the short-term efficacy of 2 versus 3 cycles of neoadjuvant immunotherapy combined with chemotherapy in patients with esophageal squamous cell carcinoma Yi Gan, Ting Bao, Zhiwei Tang, Chao Cheng, Haoshuai Zhu J. Cancer 2025; 16(1): 279-287. doi:10.7150/jca.102215 Full text PDF PubMed PMC


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The cellular signaling crosstalk between memory B cells and tumor cells in nasopharyngeal carcinoma cannot be overlooked: Their involvement in tumor progression and treatment strategy is significant Haiyu Li, Yanjie Bian, Zhikai Xiahou, Zhijie Zhao, Fu Zhao, Qinghan Zhang J. Cancer 2025; 16(1): 288-314. doi:10.7150/jca.101420 Full text PDF PubMed PMC


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WTAP regulates Mitochondrial damage and Lipid oxidation in HCC by NOA1 mediated m6A modification Sheng Liu, Mei Shang, Jiao Gong, Hengchang Sun, Bo Hu J. Cancer 2025; 16(1): 315-330. doi:10.7150/jca.102618 Full text PDF PubMed PMC


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The causal association between neutrophil counts and the risk of lung cancer: a Mendelian randomization study Yunzhao Ren, Zhaojun Lu, Xiaoxue Liu J. Cancer 2025; 16(1): 331-338. doi:10.7150/jca.100884 Full text PDF PubMed PMC


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Comprehensive analysis of genomic alterations and novel prognostic biomarkers, and establishment of prediction models of metastasis in metastatic non-small cell lung cancer Kangwei Wang, Meifeng Ye, Zexun Mo, Xiaomei Huang, Yujun Li, Shuquan Wei J. Cancer 2025; 16(1): 339-350. doi:10.7150/jca.97070 Full text PDF PubMed PMC


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SIGLEC1 as a novel prognostic factor is regulated by Yiqi Huayu Jiedu Decoction in colorectal cancer Yejin Zhu, Xinping Wang, Qianyi Wang, Shanfan Shi, Jun He, Chao Jiang J. Cancer 2025; 16(1): 351-367. doi:10.7150/jca.99278 Full text PDF PubMed PMC

Reviews

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Technical and Biological Biases in Bulk Transcriptomic Data Mining for Cancer Research Hengrui Liu, Yiying Li, Miray Karsidag, Tiffany Tu, Panpan Wang J. Cancer 2025; 16(1): 34-43. doi:10.7150/jca.100922 Full text PDF PubMed PMC


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Insights into Structure and Function of Growth Arrest Specific 2 (GAS2) Wenjuan Ma, Jiawei Lin, Rongyao Ma, Yang Bai, Di Wu, Xiuyan Zhang, Haixia Zhou, Yun Zhao, Lei Zhang J. Cancer 2025; 16(1): 146-156. doi:10.7150/jca.102893 Full text PDF PubMed PMC


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The Role of AIM2 in Cancer Development: Inflammasomes and Beyond Lina Sui, Yuling Xi, Siping Zheng, Qiuxiang Xiao, Zhiping Liu J. Cancer 2025; 16(1): 157-170. doi:10.7150/jca.101473 Full text PDF PubMed PMC


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New Horizons of Biomarkers in Metastatic Thyroid Cancer Alicia Sanchez Cendra, Leonel Pekarek, Beatriz Iglesias Pedrejón, Loreto Bernier, Eduardo David Roberts Cervantes, Cristina Sanchez Cendra, Javier Cassinello, Laura López-Gonzalez, Félix Mañez, Concepción Blanco Carrero, Clara Tasende Fernández, Tomás Ratia Giménez, Diego Martín Córdova García, Alberto Gutiérrez-Calvo, Melchor Álvarez-Mon, Raúl Díaz-Pedrero, Miguel A Ortega J. Cancer 2025; 16(1): 241-264. doi:10.7150/jca.101395 Full text PDF PubMed PMC

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