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Volume 12 (15); 2021

Research Papers

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An Italian National Survey on Ovarian Cancer Treatment at first diagnosis. There's None so Deaf as those who will not Hear
Vincenzo Dario Mandato, Federica Torricelli, Stefano Uccella, Debora Pirillo, Gino Ciarlini, Gabriele Ruffo, Gianluca Annunziata, Gloria Manzotti, Sandro Pignata, Lorenzo Aguzzoli
J. Cancer 2021; 12(15): 4443-4454. doi:10.7150/jca.57894
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Effect of surgical margin on postoperative prognosis in patients with solitary hepatocellular carcinoma: A propensity score matching analysis
Zewen Zhou, Lunan Qi, Qiuyan Mo, Yingchun Liu, Xianguo Zhou, Zihan Zhou, Xiumei Liang, Shixiong Feng, Hongping Yu
J. Cancer 2021; 12(15): 4455-4462. doi:10.7150/jca.57896
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis
Mei-Juan Dian, Jing Li, Xiao-Ling Zhang, Zi-Jian Li, Ying Zhou, Wei Zhou, Qiu-Ling Zhong, Wen-Qian Pang, Xiao-Lin Lin, Tao Liu, Yi-An Liu, Yong-Long Li, Liu-Xin Han, Wen-Tao Zhao, Jun-Shuang Jia, Sheng-Jun Xiao, Dong Xiao, Jia-Wei Xia, Wei-Chao Hao
J. Cancer 2021; 12(15): 4463-4477. doi:10.7150/jca.60008
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Suitability of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration versus Paired Transbronchial Biopsy Specimens for Evaluating Programmed Death Ligand-1 Expression in Stage III and IV Lung Cancer: A Comparative Retrospective Study
Hiroki Matsuoka, Tomoyuki Araya, Toshiyuki Kita, Nanao Terada, Kenta Yamamura, Shingo Nishikawa, Yuichi Tambo, Takashi Sone, Hideharu Kimura, Akishi Ooi, Satomi Kasashima, Atsuhiro Kawashima, Kazuo Kasahara
J. Cancer 2021; 12(15): 4478-4487. doi:10.7150/jca.55738
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pre-treatment high body mass index is associated with poor survival in Asian premenopausal women with localized breast cancer
Yung-Chang Lin, Hsiao-Hsiang Cheng, Shin-Cheh Chen, Wen-Chi Shen, Yi-Ting Huang
J. Cancer 2021; 12(15): 4488-4496. doi:10.7150/jca.59133
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Clinical significance of C-Reactive Protein to Lymphocyte Count Ratio as a prognostic factor for Survival in Non-small Cell Lung Cancer Patients undergoing Curative Surgical Resection
Jae-Joon Hwang, Joon Young Hur, Wankyu Eo, Soomin An, Dae Hyun Kim, Sookyung Lee
J. Cancer 2021; 12(15): 4497-4504. doi:10.7150/jca.58094
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Positive Impact of Intraoperative Epidural Ropivacaine Infusion on Oncologic Outcomes in Pancreatic Cancer Patients Undergoing Pancreatectomy: A Retrospective Cohort Study
Wannan Chen, Yaolin Xu, Yueming Zhang, Wenhui Lou, Xiaodan Han
J. Cancer 2021; 12(15): 4513-4521. doi:10.7150/jca.57661
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Safety and efficacy of drug-eluting bead transarterial chemoembolization with CalliSpheres® microsphere for hepatocellular carcinoma with portal vein tumor thrombus: a preliminary study
Tan-Yang Zhou, Sheng-Qun Chen, Hong-Liang Wang, Sheng-Ming Weng, Guan-Hui Zhou, Yue-Lin Zhang, Chun-Hui Nie, Tong-Yin Zhu, Bao-Quan Wang, Zi-Niu Yu, Li Jing, Feng Chen, Jun-Hui Sun
J. Cancer 2021; 12(15): 4522-4529. doi:10.7150/jca.54650
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SLC39A7 promotes malignant behaviors in glioma via the TNF-α-mediated NF-κB signaling pathway
Lian Chen, Jinpeng Zhou, Long Li, Junshuang Zhao, Hao Li, Wei Zheng, Jinkun Xu, Zhitao Jing
J. Cancer 2021; 12(15): 4530-4541. doi:10.7150/jca.54158
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Flavonoid GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling
Ye Gu, Jiejie Yu, Cong Ding, Yifeng Zhou, Jiangfeng Yang, WeiPing Yu, Xiaofeng Zhang, Haitao Huang
J. Cancer 2021; 12(15): 4542-4551. doi:10.7150/jca.58710
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis
Jing Feng, Fang-yuan Gao, Yan-ying Li, Xi-yun Xiao, Jie Xi
J. Cancer 2021; 12(15): 4552-4560. doi:10.7150/jca.54148
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapid multi-dynamic algorithm for gray image analysis of the stroma percentage on colorectal cancer
Tengfei Li, Zekuan Yu, Yan Yang, Zhongmao Fu, Ziang Chen, Qi Li, Kundong Zhang, Zai Luo, Zhengjun Qiu, Chen Huang
J. Cancer 2021; 12(15): 4561-4573. doi:10.7150/jca.58887
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway
Xin Xie, Zhangjian Zhou, Yongchun Song, Xin Zhang, Chengxue Dang, Hao Zhang
J. Cancer 2021; 12(15): 4574-4584. doi:10.7150/jca.59138
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hallmark microRNA signature in liquid biopsy identifies hepatocellular carcinoma and differentiates it from liver metastasis
Victor Chun-Lam Wong, Ming-In Wong, Chi-Tat Lam, Maria Li Lung, Ka-On Lam, Victor Ho-Fun Lee
J. Cancer 2021; 12(15): 4585-4594. doi:10.7150/jca.59933
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CREBBP knockdown suppressed proliferation and promoted chemo-sensitivity via PERK-mediated unfolded protein response in ovarian cancer
Haoyang Hu, Sheng Yin, Ruyue Ma, Rujun Chen, Shuqing Li, Yaping Chen, He Fei, Lina Yang
J. Cancer 2021; 12(15): 4595-4603. doi:10.7150/jca.56135
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RNF43 and PWWP2B inhibit cancer cell proliferation and are predictive or prognostic biomarker for FDA-approved drugs in patients with advanced gastric cancer
Sung-Hwa Sohn, Hee Jung Sul, Bohyun Kim, Hyeong Su Kim, Bum Jun Kim, Hyun Lim, Ho Suk Kang, Jae Seung Soh, Kab Choong Kim, Ji Woong Cho, Jinwon Seo, Youngho Koh, Dae Young Zang
J. Cancer 2021; 12(15): 4616-4625. doi:10.7150/jca.56014
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer
Clara Yuri Kim, Yu Cheon Kim, Ji Hoon Oh, Myoung Hee Kim
J. Cancer 2021; 12(15): 4626-4637. doi:10.7150/jca.59740
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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IL-11 mediates the Radioresistance of Cervical Cancer Cells via the PI3K/Akt Signaling Pathway
Ruige Sun, Chunli Chen, Xinzhou Deng, Fengqin Wang, Shimao Song, Qiang Cai, Jincheng Wang, Te Zhang, Mingliang Shi, Qing Ke, Zhiguo Luo
J. Cancer 2021; 12(15): 4638-4647. doi:10.7150/jca.56185
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Impact of Body Mass Index on Local Recurrence according to Intrinsic Subtype Approximation in Korean Women with Early Stage Invasive Breast Cancer Receiving Contemporary Treatments
Sang-Won Kim, Mison Chun, Yong Sik Jung, Young-Taek Oh, O Kyu Noh, Oyeon Cho
J. Cancer 2021; 12(15): 4648-4654. doi:10.7150/jca.59064
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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High level of CD73 predicts poor prognosis of intrahepatic cholangiocarcinoma
Ya-ping Xu, Ying-Qun Zhou, Yu-Jie Zhao, Yan Zhao, Feng Wang, Xiao-Yong Huang, Chuan-Yong Guo
J. Cancer 2021; 12(15): 4655-4660. doi:10.7150/jca.51038
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ApoM is an important potential protective factor in the pathogenesis of primary liver cancer
Yaping Bai, Wenjun Pei, Xiao Zhang, Huihao Zheng, Changchun Hua, Jiao Min, Lisheng Hu, Shuangqiu Du, Zuyue Gong, Jialin Gao, Yao Zhang
J. Cancer 2021; 12(15): 4661-4671. doi:10.7150/jca.53115
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Pentraxin-3 inhibits milky spots metastasis of gastric cancer by inhibiting M2 macrophage polarization
Xinye Cui, Tao Qin, Zhengdong Zhao, Guang Yang, Jaceline Gislaine Pires Sanches, Qingqing Zhang, Shujun Fan, Liang Cao, Xiang Hu
J. Cancer 2021; 12(15): 4686-4697. doi:10.7150/jca.58698
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer
Karolina Buchholz, Paulina Antosik, Dariusz Grzanka, Maciej Gagat, Marta Smolińska, Alina Grzanka, Arkadiusz Gzil, Anna Kasperska, Anna Klimaszewska-Wiśniewska
J. Cancer 2021; 12(15): 4698-4709. doi:10.7150/jca.55511
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects
Xu Deng, Meiling Zuo, Zhifang Pei, Yuanlin Xie, Zhongbao Yang, Zhihui Zhang, Minna Jiang, Dabin Kuang
J. Cancer 2021; 12(15): 4710-4721. doi:10.7150/jca.58873
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Clinicopathologic factors affecting discrepancies in HER2 overexpression between core needle biopsy and surgical biopsy in breast cancer patients according to neoadjuvant treatment or not
Young-Hoon Jeong, Soon Auck Hong, Hye Shin Ahn, Soo kyung Ahn, Min Kyoon Kim
J. Cancer 2021; 12(15): 4722-4728. doi:10.7150/jca.59419
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Data mining analysis of the prognostic impact of N6-methyladenosine regulators in patients with endometrial adenocarcinoma
Junyu Zhai, Shang Li, Yu Li, Yanzhi Du
J. Cancer 2021; 12(15): 4729-4738. doi:10.7150/jca.50868
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Predictive Value of Routine Blood Test in patients with Early Esophageal Cancer: A Matched Case-Control Study
Xiaoying Zhou, Han Chen, Weifeng Zhang, Xueliang Li, Xinmin Si, Guoxin Zhang
J. Cancer 2021; 12(15): 4739-4744. doi:10.7150/jca.56029
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Prognostic and Therapeutic Significance of BTN3A Proteins in Tumors
Sihan Chen, Zhangyun Li, Wenyi Huang, Yanyan Wang, Shaohua Fan
J. Cancer 2021; 12(15): 4505-4512. doi:10.7150/jca.57831
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circular RNAs as novel potential biomarkers for pancreatic cancer
Shanshan Liu, Qiuyue Li, Yan Ma, Christopher Corpe, Jin Wang
J. Cancer 2021; 12(15): 4604-4615. doi:10.7150/jca.58640
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hindsight: Review of Preclinical Disease Models for the Development of New Treatments for Uveal Melanoma
Caoimhe Goldrick, Letizia Palanga, Bobby Tang, Grace Mealy, John Crown, Noel Horgan, Susan Kennedy, Naomi Walsh
J. Cancer 2021; 12(15): 4672-4685. doi:10.7150/jca.53954
[Abstract] [Full text] [PDF] [PubMed] [PMC]