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Volume 12 (12); 2021

Research Papers

Graphic abstract

Prognostic Value of Peripheral Blood Lymphocyte/monocyte Ratio in Lymphoma
Feiqiong Gao, Jianlai Hu, Jiawei Zhang, Yang Xu
J. Cancer 2021; 12(12): 3407-3417. doi:10.7150/jca.50552
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Graphic abstract

Acidic extracellular pH induces autophagy to promote anoikis resistance of hepatocellular carcinoma cells via downregulation of miR-3663-3p
Siying Wang, Yuanyuan Lv, Yangyang Zhou, Jing Ling, Hui Wang, Dishui Gu, Cun Wang, Wenxin Qin, Xingling Zheng, Haojie Jin
J. Cancer 2021; 12(12): 3418-3426. doi:10.7150/jca.51849
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Graphic abstract

Computerized Assessment of the Tumor-stromal Ratio and Proposal of a Novel Nomogram for Predicting Survival in Invasive Breast Cancer
Xu Qian, Feng Xiao, Yuan-Yuan Chen, Jing-Ping Yuan, Xiao-Hong Liu, Lin-Wei Wang, Bin Xiong
J. Cancer 2021; 12(12): 3427-3438. doi:10.7150/jca.55750
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Graphic abstract

Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma
Ping Luo, Chunzi Liang, Wei Jing, Man Zhu, Hu Zhou, Hongyan Chai, Paul F. Worley, Jiancheng Tu
J. Cancer 2021; 12(12): 3439-3447. doi:10.7150/jca.52118
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Intrahepatic Cholangiocarcinoma Cells Promote Epithelial-mesenchymal Transition of Hepatocellular Carcinoma Cells by Secreting LAMC2
Wenda Cen, Jiandong Li, Chenhao Tong, Weiguang Zhang, Yunfeng Zhao, Baochun Lu, Jianhua Yu
J. Cancer 2021; 12(12): 3448-3457. doi:10.7150/jca.55627
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Graphic abstract

IGHG1 induces EMT in gastric cancer cells by regulating TGF-β/SMAD3 signaling pathway
Yuxuan Li, Pan Wang, Dongmei Ye, Xue Bai, Xuemei Zeng, Qiang Zhao, Zhiwei Zhang
J. Cancer 2021; 12(12): 3458-3467. doi:10.7150/jca.56056
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The Effects of Lentivirus-Mediated Gene Silencing of RARβ on the Stemness Capability of Non-Small Cell Lung Cancer
Noor Hanis Abu Halim, Norashikin Zakaria, Kumitaa Theva Das, Juntang Lin, Moon Nian Lim, Kamal Shaik Fakiruddin, Badrul Hisham Yahaya
J. Cancer 2021; 12(12): 3468-3485. doi:10.7150/jca.50793
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Graphic abstract

SOX4 as biomarker in hepatitis B virus-associated hepatocellular carcinoma
Jian-Lv Huang, Xiang-Kun Wang, Xi-Wen Liao, Chuang-Ye Han, Ting-Dong Yu, Ke-Tuan Huang, Cheng-Kun Yang, Xiao-Guang Liu, Long Yu, Guang-Zhi Zhu, Hao Su, Wei Qin, Quan-Fa Han, Zheng-Qian Liu, Xin Zhou, Jun-Qi Liu, Xin-Ping Ye, Tao Peng
J. Cancer 2021; 12(12): 3486-3500. doi:10.7150/jca.46579
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Graphic abstract

Characteristics of Infiltrating Immune Cells and a Predictive Immune Model for Cervical Cancer
Ruanmin Zou, Ruihong Gu, Xia Yu, Yingying Hu, Junhui Yu, Xiangyang Xue, Xueqiong Zhu
J. Cancer 2021; 12(12): 3501-3514. doi:10.7150/jca.55970
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Prognostic Value of Autophagy, Microsatellite Instability, and KRAS Mutations in Colorectal Cancer
Yuanyuan Wang, Zhi Zhao, Jing Zhuang, Xinxin Wu, Zhizhong Wang, Bing Zhang, Ge Gao, Yinping Zhang, Caili Guo, Qingxin Xia
J. Cancer 2021; 12(12): 3515-3528. doi:10.7150/jca.51430
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Development and validation of nomogram with tumor microenvironment-related genes and clinical factors for predicting overall survival of endometrial cancer
Qian Chen, Shu Wang, Jing-He Lang
J. Cancer 2021; 12(12): 3530-3538. doi:10.7150/jca.51493
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Global Trend in Research and Development of CDK4/6 Inhibitors for Clinical Cancer Therapy: A Bibliometric Analysis
Hongna Lai, Wei Jiang, Jianli Zhao, Xiaoxiao Dinglin, Yudong Li, Shunying Li, Ying Wang, Herui Yao
J. Cancer 2021; 12(12): 3539-3547. doi:10.7150/jca.51609
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Graphic abstract

Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT
Jianwen Ye, Lei Qi, Jialu Liang, Ke Zong, Wentao Liu, Renfeng Li, Ruo Feng, Wenlong Zhai
J. Cancer 2021; 12(12): 3548-3557. doi:10.7150/jca.50292
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Severity of COVID-19 in Cancer patients versus patients without Cancer: A Propensity Score Matching Analysis
Chao Liu, Kai Wang, Luyuan Li, Qingquan Lv, Yumei Liu, Tian Hu, Jonathan C. Trent, Bing Sun, Qinyong Hu
J. Cancer 2021; 12(12): 3558-3565. doi:10.7150/jca.54205
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Malignant Evaluation and Clinical Prognostic Values of M6A RNA Methylation Regulators in Prostate Cancer
Qijie Zhang, Jiaochen Luan, Lebin Song, Xiyi Wei, Jiadong Xia, Ninghong Song
J. Cancer 2021; 12(12): 3575-3586. doi:10.7150/jca.55140
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Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway
Zijie Wang, Hui Liu, Qing Hu, Lei Shi, Muhan Lü, Mingming Deng, Gang Luo
J. Cancer 2021; 12(12): 3597-3610. doi:10.7150/jca.55519
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MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments
Hai Zhu, Gang Wang, Haixing Zhu, Aman Xu
J. Cancer 2021; 12(12): 3611-3625. doi:10.7150/jca.58158
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Graphic abstract

Five-gene signature associating with Gleason score serve as novel biomarkers for identifying early recurring events and contributing to early diagnosis for Prostate Adenocarcinoma
Lingyu Zhang, Yu Li, Xuchu Wang, Ying Ping, Danhua Wang, Ying Cao, Yibei Dai, Weiwei Liu, Zhihua Tao
J. Cancer 2021; 12(12): 3626-3647. doi:10.7150/jca.52170
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Graphic abstract

Neuropilin-1 predicts poor prognosis and promotes tumor metastasis through epithelial-mesenchymal transition in gastric cancer
Qianna Jin, Qianqian Ren, Xiaona Chang, Haixing Yu, Xin Jin, Xiaoming Lu, Nan He, Guobin Wang
J. Cancer 2021; 12(12): 3648-3659. doi:10.7150/jca.52851
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Graphic abstract

Evolutions of the Management of Colorectal Cancer Liver Metastasis: A Bibliometric Analysis
Bao Jin, Xiang'an Wu, Gang Xu, Jiali Xing, Yuxin Wang, Huayu Yang, Shunda Du, Yilei Mao
J. Cancer 2021; 12(12): 3660-3670. doi:10.7150/jca.52842
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Systemic Inflammatory Score predicts Overall Survival in patients with Cervical Cancer
Mu Xu, Qibin Wu, Liangzhi Cai, Xiaoqi Sun, Xiaoyan Xie, Pengming Sun
J. Cancer 2021; 12(12): 3671-3677. doi:10.7150/jca.56170
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Blood leukocytes methylation levels analysis indicate methylated plasma test is a promising tool for colorectal cancer early detection
Zhiliang Chen, Guodong Zhao, Kai Wang, Xiaomei Wang, Yong Ma, Shangmin Xiong, Minxue Zheng, Sujuan Fei
J. Cancer 2021; 12(12): 3678-3685. doi:10.7150/jca.57114
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Prospective Non-Randomized Study of Intraoperative Assessment of Surgical Resection Margin of Colo-Rectal Liver Metastases
Mladjan Protic, Olivera Krsmanovic, Nenad Solajic, Biljana Kukic, Ivan Nikolic, Bogdan Bogdanovic, Zoran Radovanovic, Milana Kresoja, Ciaran Mannion, Yan-Gao Man, Alexander Stojadinovic
J. Cancer 2021; 12(12): 3701-3714. doi:10.7150/jca.58580
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Graphic abstract

A Novel Set of Immune-associated Gene Signature predicts Biochemical Recurrence in Localized Prostate Cancer Patients after Radical Prostatectomy
Jiao-chen Luan, Qi-jie Zhang, Kai Zhao, Xiang zhou, Liang-yu Yao, Tong-tong Zhang, Teng-yue Zeng, Jia-dong Xia, Ning-hong Song
J. Cancer 2021; 12(12): 3715-3725. doi:10.7150/jca.51059
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MiR-146b-3p regulates proliferation of pancreatic cancer cells with stem cell-like properties by targeting MAP3K10
Min Zhou, Yang Gao, Min Wang, Xingjun Guo, Xu Li, Feng Zhu, Simiao Xu, Renyi Qin
J. Cancer 2021; 12(12): 3726-3740. doi:10.7150/jca.48418
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Graphic abstract

KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3β signaling
Yan Zhou, Leping Yang, Li Xiong, Kunpeng Wang, Xuyang Hou, Qinglong Li, Fanhua Kong, Xi Liu, Jun He
J. Cancer 2021; 12(12): 3741-3753. doi:10.7150/jca.52103
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Reviews

Graphic abstract

Mechanism of PKM2 affecting cancer immunity and metabolism in Tumor Microenvironment
Mengxi Chen, Huan Liu, Zhang Li, Alex Lau Ming, Honglei Chen
J. Cancer 2021; 12(12): 3566-3574. doi:10.7150/jca.54430
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Graphic abstract

Advances in cancer treatment: a new therapeutic target, Annexin A2
Zinan Li, Lifeng Yu, Baohui Hu, Lianze Chen, Mingyi Jv, Lin Wang, Chenyi Zhou, Minjie Wei, Lin Zhao
J. Cancer 2021; 12(12): 3587-3596. doi:10.7150/jca.55173
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Graphic abstract

Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach
Aayush Jain, Chikezie O. Madu, Yi Lu
J. Cancer 2021; 12(12): 3686-3700. doi:10.7150/jca.57776
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Retraction

Retraction: Oxymatrine Synergistically Potentiates the Antitumor Effects of Cisplatin in Human Gastric Cancer Cells
Yan Liu, Lei Qin, Tingting Bi, Wei Dai, Wei Liu, Quangen Gao, Genhai Shen
J. Cancer 2021; 12(12): 3529. doi:10.7150/jca.61392
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