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Volume 12 (21); 2021

Research Papers

Graphic abstract

Development and validation of nomogram based on a novel platelet index score to predict prognosis in patients with renal cell carcinoma
Ruotao Xiao, Yanchun Qin, Lei Liu, Zhigang Chen, Bin Yang, Chuxiao Xu, Wei He, Cheng Liu, Lulin Ma
J. Cancer 2021; 12(21): 6301-6309. doi:10.7150/jca.60268
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Metformin and arsenic trioxide synergize to trigger Parkin/pink1-dependent mitophagic cell death in human cervical cancer HeLa cells
Jing Chen, Cunmin Zhou, Juan Yi, Jingjing Sun, Bei Xie, Zhewen Zhang, Qunfeng Wang, Gang Chen, Suya Jin, Jinxia Hou, Miao Qin, Lina Wang, Hulai Wei
J. Cancer 2021; 12(21): 6310-6319. doi:10.7150/jca.61299
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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FAM83A Promotes the Proliferative and Invasive Abilities of Cervical Cancer Cells via Epithelial-Mesenchymal Transition and the Wnt Signaling Pathway
Chong Lan, Chen-Chen Liu, Xiao-Cui Nie, Lei Lei, Zhang-Xian Xiao, Ming-Xi Li, Xue-Nan Tang, Ming-Yu Jia, Hong-Tao Xu
J. Cancer 2021; 12(21): 6320-6329. doi:10.7150/jca.62563
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Role of long intergenic non-protein coding RNA 00152 in pancreatic cancer glycolysis via the manipulation of the microRNA-185-5p/Krüppel-like factor 7 axis
Haifeng Li, Hao Shen, Peng Xie, Zheng Zhang, Lishan Wang, Yang Yang, Zeqian Yu, Zhangjun Cheng, Jiahua Zhou
J. Cancer 2021; 12(21): 6330-6343. doi:10.7150/jca.63128
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA MALAT1 was regulated by HPV16 E7 independently of pRB in cervical cancer cells
Ting Wang, Wei Zhang, Wenbin Huang, Zichun Hua, Shufeng Li
J. Cancer 2021; 12(21): 6344-6355. doi:10.7150/jca.61194
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TRK inhibitors block NFKB and induce NRF2 in TRK fusion-positive colon cancer
Sung-Hwa Sohn, Hee Jung Sul, Bohyun Kim, Bum Jun Kim, Hyeong Su Kim, Dae Young Zang
J. Cancer 2021; 12(21): 6356-6362. doi:10.7150/jca.60845
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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RUNX1 regulates the proliferation and chemoresistance of colorectal cancer through the Hedgehog signaling pathway
Qingyuan Li, Qiuhua Lai, Chengcheng He, Haonan Zhang, Xingzhu Pan, Haolin Li, Qun Yan, Yuxin Fang, Side Liu, Aimin Li
J. Cancer 2021; 12(21): 6363-6371. doi:10.7150/jca.51338
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD73 is a hypoxia-responsive gene and promotes the Warburg effect of human gastric cancer cells dependent on its enzyme activity
Xiaopeng Cao, Ziman Zhu, Yi Cao, Jia Hu, Min Min
J. Cancer 2021; 12(21): 6372-6382. doi:10.7150/jca.62387
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The anti-osteosarcoma effect from panax notoginseng saponins by inhibiting the G0 / G1 phase in the cell cycle and affecting p53-mediated autophagy and mitochondrial apoptosis
Guangtao Han, Yubiao Zhang, Ting Liu, Jianping Li, Haohuan Li
J. Cancer 2021; 12(21): 6383-6392. doi:10.7150/jca.54602
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA TUSC8 suppresses the proliferation and migration of esophageal cancer cells by downregulation of VEGFA
Rui Hu, Rui Bi, Lianyong Jiang, Xuhui Yang, Yuan Zhong, Xiao Xie
J. Cancer 2021; 12(21): 6393-6400. doi:10.7150/jca.57814
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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L1CAM is not a reliable predictor for lymph node metastases in endometrial cancer, but L1CAM positive patients benefit from radiotherapy
Deborah Zeiter, Tatjana Vlajnic, Andreas Schötzau, Viola Heinzelmann-Schwarz, Céline Montavon
J. Cancer 2021; 12(21): 6401-6410. doi:10.7150/jca.59283
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DDIT4 overexpression associates with poor prognosis in lung adenocarcinoma
Li Song, Zhiyao Chen, Menghua Zhang, Mingli Zhang, Xiaoyun Lu, Chunsun Li, Liyan Miao
J. Cancer 2021; 12(21): 6422-6428. doi:10.7150/jca.60118
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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FGF14-AS2 accelerates tumorigenesis in glioma by forming a feedback loop with miR-320a/E2F1 axis
Peng Zhang, Xueping Gu, Na Zhang, Liang Liu, Xuchen Dong, Haoran Li, Shan Cheng, Suwen Li, Jiaqi Yuan, Yongdong Li, Jun Dong
J. Cancer 2021; 12(21): 6429-6438. doi:10.7150/jca.62120
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Suppressing LncRNA HOXA-AS3 by CRISPR-dCas9 inhibits pancreatic cancer development
Xiaoli Zhang, Hongbo Zhu, Xiaoguang Qu, Ziying Yu, Jing Zhang
J. Cancer 2021; 12(21): 6439-6444. doi:10.7150/jca.62631
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Metastasis patterns and prognosis in breast cancer patients aged ≥ 80 years: a SEER database analysis
Youming Han, Zhilin Sui, Yongsheng Jia, Hailong Wang, Yan Dong, Hongdian Zhang, Zhigang Li, Zhentao Yu
J. Cancer 2021; 12(21): 6445-6453. doi:10.7150/jca.63813
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Optimal Size Criterion for Malignant Lymph Nodes and a Novel Lymph Node Clinical Staging System for Unresectable Esophageal Squamous Cell Carcinoma: Evaluation by Multislice Spiral Computed Tomography
Hang Wang, Zheng Lin, Yimin Lin, Ruigang Huang, Moliang Qiu, Xiane Peng, Fei He, Liping Huang, Zhisheng Xiang, Wanting Lu, Siyou Yan, Shuang Liu, Huimin Yang, Zhihui Zhang, Zhijian Hu
J. Cancer 2021; 12(21): 6454-6464. doi:10.7150/jca.61994
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CA724 Predicts Tumor Regression Grade in Locally Advanced Gastric Cancer Patients with Neoadjuvant Chemotherapy
Yilin Tong, Yanmei Zhu, Yan Zhao, Chengyao Jiang, Wentao Wang, Zexing Shan, Fan Sun, Dong Liu, Jianjun Zhang
J. Cancer 2021; 12(21): 6465-6472. doi:10.7150/jca.60694
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Tracking cancer lesions on surgical samples of gastric cancer by artificial intelligent algorithms
Ruixin Yang, Chao Yan, Sheng Lu, Jun Li, Jun Ji, Ranlin Yan, Fei Yuan, Zhenggang Zhu, Yingyan Yu
J. Cancer 2021; 12(21): 6473-6483. doi:10.7150/jca.63879
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Expression profile of epithelial-mesenchymal transition-related genes as a prognostic biomarker of endometrial cancer
Lei Ye, Xiaojun Wang, Bilan Li
J. Cancer 2021; 12(21): 6484-6496. doi:10.7150/jca.62729
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Safety and efficacy of fecal microbiota transplantation to treat and prevent recurrent Clostridioides difficile in cancer patients
Hiba Ali, Shruti Khurana, Weijie Ma, Yuanzun Peng, Zhi-Dong Jiang, Herbert DuPont, Hao Chi Zhang, Anusha S. Thomas, Pablo Okhuysen, Yinghong Wang
J. Cancer 2021; 12(21): 6498-6506. doi:10.7150/jca.59251
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Analysis of Methylation‐driven Genes in Pancreatic Ductal Adenocarcinoma for Predicting Prognosis
Zihan Zhang, Rui Zhu, Wentian Sun, Jun Wang, Jin Liu
J. Cancer 2021; 12(21): 6507-6518. doi:10.7150/jca.53208
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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miR-328-3p promotes migration and invasion by targeting H2AFX in head and neck squamous cell carcinoma
Huiling Ma, Chao Liu, Shuiting Zhang, Wenhui Yuan, Junli Hu, Donghai Huang, Xin Zhang, Yong Liu, Yuanzheng Qiu
J. Cancer 2021; 12(21): 6519-6530. doi:10.7150/jca.60743
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circular RNA hsa_circ_0001306 Functions as a Competing Endogenous RNA to Regulate FBXW7 Expression by Sponging miR-527 in Hepatocellular Carcinoma
Yufan Wu, Taihe Fan, Yubin Zhao, Rongkuan Hu, Dongdong Yan, Ding Sun, Ling Gao, Lei Qin, Xiaofeng Xue
J. Cancer 2021; 12(21): 6531-6542. doi:10.7150/jca.61381
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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P68 RNA Helicase facilitates Breast Cancer progression by promoting Proliferation and Migration via PDGFR-β/AR axis
Neha Panchbhai, Chakra R. Turaga, Malvika Sharma, Ganesh Satyanarayana, Zhi-Ren Liu
J. Cancer 2021; 12(21): 6543-6552. doi:10.7150/jca.61505
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The E3 Ubiquitin Ligase HOIP inhibits Cancer Cell Apoptosis via modulating PTEN stability
Zhiguo Niu, Xin Li, Shuxiao Dong, Jianhui Gao, Qingsong Huang, Huijie Yang, Hui Qian, Shu Zhuo, Ting Zhuang, Jian Zhu, Yinlu Ding, Wenrong Xu
J. Cancer 2021; 12(21): 6553-6562. doi:10.7150/jca.61996
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Quantitative proteomic analysis reveals sophisticated metabolic alteration and identifies FMNL1 as a prognostic marker in clear cell renal cell carcinoma
Gui Ma, Zirui Wang, junyao Liu, Shengjun Fu, Lili Zhang, Duo Zheng, Panfeng Shang, Zhongjin Yue
J. Cancer 2021; 12(21): 6563-6575. doi:10.7150/jca.62309
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway
Quhui Wu, Da Li, Taoli Sun, Jian Liu, Huiping Ou, Lei Zheng, Xuyang Hou, Wenqun Li, Fuyuan Fan
J. Cancer 2021; 12(21): 6576-6587. doi:10.7150/jca.62779
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis
Wenrui Ye, Cong Luo, Chenglong Li, Zhixiong Liu, Fangkun Liu
J. Cancer 2021; 12(21): 6588-6599. doi:10.7150/jca.63236
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Mechano-Signaling Aspects of Hepatocellular Carcinoma
Mehak Passi, Stefan Zahler
J. Cancer 2021; 12(21): 6411-6421. doi:10.7150/jca.60102
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum

High Expression of Cancer-Derived Glycosylated Immunoglobulin G Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma: Erratum
Ming Cui, Lei You, Bang Zheng, Xinmei Huang, Qiaofei Liu, Jing Huang, Boju Pan, Xiaoyan Qiu, Quan Liao, Yupei Zhao
J. Cancer 2021; 12(21): 6497. doi:10.7150/jca.32930
[Abstract] [Full text] [PDF] [PubMed] [PMC]