J Cancer 2019; 10(25):6191-6198. doi:10.7150/jca.36707

Research Paper

The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer

Ming-Chao Huang1,2,3, Ying-Hsiang Chou1,4,5, Huang-Pin Shen1,6,7, Soo-Cheen Ng6,7, Yueh‐Chun Lee1,5,7, Yi-Hung Sun1,8, Chun-Fang Hsu1,6, Shun-Fa Yang1,9, Po-Hui Wang1,6,7,9✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan
3. Mackay Medicine, Nursing, and Management College, Taipei, Taiwan
4. Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan
5. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan
6. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
7. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
8. Department of Obstetrics and Gynecology, Chi-Mei Foundation Medical Center, Tainan, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

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Citation:
Huang MC, Chou YH, Shen HP, Ng SC, Lee Y, Sun YH, Hsu CF, Yang SF, Wang PH. The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer. J Cancer 2019; 10(25):6191-6198. doi:10.7150/jca.36707. Available from http://www.jcancer.org/v10p6191.htm

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Abstract

The purposes of the current study were conducted to explore the relationships among long non-coding RNA gene H19 (LncRNA H19) polymorphisms and clinicopathological characteristics of uterine cervical cancer, and patient prognosis in Taiwan. Five genetic variants of LncRNA H19 rs3024270, rs2839698, rs3741219, rs2107425 and rs217727 were recruited from one hundred and thirty-four patients with invasive cancer, 101 with high-grade cervical intraepithelial neoplasia (CIN) of uterine cervix and 325 controls and their genetic distributions were determined. It indicated no associations of these LncRNA H19 genetic variants with development of cervical cancer. CC/CT in LncRNA H19 rs2839698 exhibited less risk to have pelvic lymph node metastasis [Odds ratio (OR): 0.19, 95% Confidence interval (CI):0.04-0.82, p=0.028)], as compared with TT. Meanwhile, cervical cancer patients with AA/AG in rs3741219 also had less risk to develop pelvic lymph node metastasis (OR: 0.17, 95% CI: 0.05-0.63, p=0.008), large tumor (OR: 0.17, 95% CI: 0.04-0.82, p=0.014) as well as parametrium (OR: 0.26, 95% CI: 0.07-0.95, p=0.045) and vagina invasion (OR: 0.25, 95% CI: 0.07-0.91, p=0.041, as compared to those with GG. However, only positive pelvic lymph node metastasis was related to worse recurrence-free survival and poor overall survival. Conclusively, it indicated no association of LncRNA H19 SNPs with cervical carcinogensis in Taiwanese women. Although genotypes TT in LncRNA H19 rs2839698 and GG in rs3741219 are related to some poor clinicopathological parameters of cervical cancer, only pelvic lymph node status could predict 5 year patient survival significantly.

Keywords: long non-coding RNA gene H19, uterine cervical cancer, clinicopathological characteristics, lymph node metastasis, 5 year survival