J Cancer 2019; 10(16):3789-3797. doi:10.7150/jca.31166


The role of Wnt signaling pathway in tumor metabolic reprogramming

Yongzhen Mo1,2,3#, Yumin Wang1,2#, Lishen Zhang2, Liting Yang1, Ming Zhou1,2,3, Xiaoling Li2, Yong Li4, Guiyuan Li1,2,3, Zhaoyang Zeng1,2,3, Wei Xiong1,2,3, Fang Xiong1,2,3✉, Can Guo1,2,3✉

1. NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
2. The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha 410078, China
3. Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
4. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
# These authors contributed equally.

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Mo Y, Wang Y, Zhang L, Yang L, Zhou M, Li X, Li Y, Li G, Zeng Z, Xiong W, Xiong F, Guo C. The role of Wnt signaling pathway in tumor metabolic reprogramming. J Cancer 2019; 10(16):3789-3797. doi:10.7150/jca.31166. Available from http://www.jcancer.org/v10p3789.htm

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The occurrence and development of tumors is a complex process involving long-term multi-factor participation. In this process, tumor cells from a set of abnormal metabolic patterns that are different from normal cells. This abnormal metabolic change is called metabolic reprogramming of tumors. Wnt signaling pathway is one of the critical signaling pathways regulating cell proliferation and differentiation. In recent years, it has been found that Wnt signaling participates in the occurrence and development of malignant tumors by affecting metabolic reprogramming. This paper reviews the role of Wnt signaling in tumor metabolic reprogramming to provide crucial theoretical guidance for targeted therapy and drug response of tumors.

Keywords: tumor metabolic reprogramming, Wnt signaling, targeted therapy