Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs

Pu, Yansong; Zhang, Tao; Wang, Jianhua; Mao, Zhijun; Duan, Baojun; Long, Yanbin; Xue, Fei; Liu, Dong; Liu, Sida; Gao, Zengzhan

doi:10.7150/jca.27183

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2018; 9(20):3669-3675. doi:10.7150/jca.27183 This issue Cite

Research Paper

Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs

Yansong Pu^1*, Tao Zhang^1*, Jianhua Wang^1✉, Zhijun Mao¹, Baojun Duan², Yanbin Long¹, Fei Xue¹, Dong Liu¹, Sida Liu¹, Zengzhan Gao¹

1. The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
2. Department of Oncology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
*Dr Yansong Pu and Dr Tao Zhang contributed equally to this work.

Citation:

Pu Y, Zhang T, Wang J, Mao Z, Duan B, Long Y, Xue F, Liu D, Liu S, Gao Z. Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. J Cancer 2018; 9(20):3669-3675. doi:10.7150/jca.27183. https://www.jcancer.org/v09p3669.htm

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Abstract

Accumulating studies confirmed that luteolin, a common dietary flavonoid which is widely distributed in plants and has diverse beneficial biological function, including anti-oxidant, anti-inflammation and anticancer properties. However, the detail mechanisms of luteolin on GC are poorly understood. Here, we investigated the anticancer effect of luteolin in GC cells in vitro and in vivo. Luteolin reduced the cell viability in a time and dose-dependent manner. Luteolin significantly inhibited cell cycle progress, colony formation, proliferation, migration, invasion and promoted apoptosis in vitro and in vivo. Luteolin also regulated these biological effects associated regulators. Mechanically, luteolin treatment regulated Notch1, PI3K, AKT, mTOR, ERK, STAT3 and P38 signaling pathways and modulated a series of miRNAs expression. These findings provide novel insight into the molecular function of luteolin which suggest its potential as a therapeutic agent for human GC.

Keywords: Luteolin, gastric cancer, EMT, prognosis, metastasis

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APA

Pu, Y., Zhang, T., Wang, J., Mao, Z., Duan, B., Long, Y., Xue, F., Liu, D., Liu, S., Gao, Z. (2018). Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. Journal of Cancer, 9(20), 3669-3675. https://doi.org/10.7150/jca.27183.

ACS

Pu, Y.; Zhang, T.; Wang, J.; Mao, Z.; Duan, B.; Long, Y.; Xue, F.; Liu, D.; Liu, S.; Gao, Z. Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. J. Cancer 2018, 9 (20), 3669-3675. DOI: 10.7150/jca.27183.

NLM

CSE

Pu Y, Zhang T, Wang J, Mao Z, Duan B, Long Y, Xue F, Liu D, Liu S, Gao Z. 2018. Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs. J Cancer. 9(20):3669-3675.

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