Immune Effects of Trastuzumab

Nuti, Marianna; Bellati, Filippo; Visconti, Valeria; Napoletano, Chiara; Domenici, Lavinia; Caccetta, Jlenia; Zizzari, Ilaria Grazia; Ruscito, Ilary; Rahimi, Hassan; Benedetti-Panici, Pierluigi; Rughetti, Aurelia

doi:10.7150/jca.2.317

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2011; 2:317-323. doi:10.7150/jca.2.317 This volume Cite

Review

Immune Effects of Trastuzumab

Marianna Nuti^✉, Filippo Bellati, Valeria Visconti, Chiara Napoletano, Lavinia Domenici, Jlenia Caccetta, Ilaria Grazia Zizzari, Ilary Ruscito, Hassan Rahimi, Pierluigi Benedetti-Panici, Aurelia Rughetti

“Sapienza” University of Rome, Italy

Citation:

Nuti M, Bellati F, Visconti V, Napoletano C, Domenici L, Caccetta J, Zizzari IG, Ruscito I, Rahimi H, Benedetti-Panici P, Rughetti A. Immune Effects of Trastuzumab. J Cancer 2011; 2:317-323. doi:10.7150/jca.2.317. https://www.jcancer.org/v02p0317.htm

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Abstract

Trastuzumab's targeted therapy has become a stronghold for human epidermal growth factor receptor 2 positive breast cancer patients. This humanized monoclonal antibody binds to the extracellular juxta-membrane domain of HER2 and inhibits the proliferation and survival of HER2 dependent cancer cells. The ways by which this molecule exerts its action have been partially elucidated but several new mechanisms are being constantly identified. Several new agents are being introduced that interfere with HER2. Several new immunotherapy strategies are being introduced in order to direct the immune system against cells and tissues that aberrantly overexpressed HER2. We review the strategies currently adopted and those suggested against HER2 expressing tumors.

Keywords: autologous cells vaccines, Trastuzumab, HER2, Lapatinib, allo-vesicles

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APA

Nuti, M., Bellati, F., Visconti, V., Napoletano, C., Domenici, L., Caccetta, J., Zizzari, I.G., Ruscito, I., Rahimi, H., Benedetti-Panici, P., Rughetti, A. (2011). Immune Effects of Trastuzumab. Journal of Cancer, 2, 317-323. https://doi.org/10.7150/jca.2.317.

ACS

Nuti, M.; Bellati, F.; Visconti, V.; Napoletano, C.; Domenici, L.; Caccetta, J.; Zizzari, I.G.; Ruscito, I.; Rahimi, H.; Benedetti-Panici, P.; Rughetti, A. Immune Effects of Trastuzumab. J. Cancer 2011, 2, 317-323. DOI: 10.7150/jca.2.317.

NLM

CSE

Nuti M, Bellati F, Visconti V, Napoletano C, Domenici L, Caccetta J, Zizzari IG, Ruscito I, Rahimi H, Benedetti-Panici P, Rughetti A. 2011. Immune Effects of Trastuzumab. J Cancer. 2:317-323.

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