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Volume 16 (10); 2025

Research Papers

Pembrolizumab versus Pembrolizumab plus Chemotherapy in Non-small Cell Lung Cancer with High PD-L1 Expression - Multicenter Real-world Evidence Study
Martin Svaton, Magdalena Knetki-Wroblewska, Petr Hosek, Gabriela Chowaniecova, Jan Spacek, Ondrej Fischer, Ondrej Bilek, Michal Hrnciarik, Diego Kauffmann-Guerrero
J. Cancer 2025; 16(10): 3015-3023. doi:10.7150/jca.113815
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Nit1 is upregulated in non-small cell lung cancer and promotes cancer cell proliferation and invasion and regulates EMT-related molecules and cyclins
Jian Wang, Biying Jiang, Xiaojing Wang, Haifeng Liu, Chuifeng Fan
J. Cancer 2025; 16(10): 3040-3047. doi:10.7150/jca.96095
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Study on the mechanism of gracillin inhibiting the proliferation of lung cancer NCI-H1299 cells based on MAPK signaling pathway
Bang Xiao, Minhong Zhang, Hai Liu, Aiping Cui, Yihe Tian, Fosheng Tang, Shichen Liao, Mingchun Li, Hao Huang, Weijie Peng, Jianqiong Yang
J. Cancer 2025; 16(10): 3048-3064. doi:10.7150/jca.113694
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Impact of PIK3CA Mutations on the Clinical Benefits of CDK 4/6 Inhibitors in HR+/HER2- Advanced Breast Cancer: An Updated Pairwise and Network Meta-Analysis
Sheng-Fan Wang, Chian-Ying Chou, Yi-Wen Chao, Tzu-Kuan Chan, Wan-Yu Yeh, Chern-En Chiang, Chen-Huan Chen, Hsin-Chen Lee, Ling-Ming Tseng, Yuh-Lih Chang, Hao-Min Cheng, Chun-Yu Liu
J. Cancer 2025; 16(10): 3065-3079. doi:10.7150/jca.111362
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RBM10 inhibits pancreatic cancer development by suppressing immune escape through PD-1 expression
Xia Gao, Xiuqin Zhang, Junjie Huang, Zhenyu Tan, Jing Yang, Liuhong Yuan, Pengjun Wang, Feier Chen, Huiyan Wu, Changyi Feng, Hong Yu, Shisan Bao, Da Fu, Kun Tao
J. Cancer 2025; 16(10): 3080-3093. doi:10.7150/jca.111459
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Investigation of CBX4 Polymorphisms and Their Association with Clinicopathological Features in Asian Patients with Oral Squamous Cell Carcinoma
Li-Chung Hung, Yi-Chung Chien, Chiao-Wen Lin, Chun-Yi Chuang, Hsiu-San Hsu, Liang-Chih Liu, Shun-Fa Yang, Yung-Luen Yu
J. Cancer 2025; 16(10): 3094-3102. doi:10.7150/jca.116232
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Characteristics of Non-mass Enhancement in Contrast-enhanced Breast MRI and Associations with Malignancy
Kamber Goksu, Ahmet Vural, Ahmet Nedim Kahraman
J. Cancer 2025; 16(10): 3103-3111. doi:10.7150/jca.114087
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Unlocking ESCC Progression: CCL15-CCR1 Axis Activates AKT/ERK1/2/c-Jun/CDK2 Pathway
Shengliang He, Yunjiu Gou, Qizhou Bo, Dacheng Jin, Songchen Han, Hui Cai
J. Cancer 2025; 16(10): 3112-3127. doi:10.7150/jca.113925
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CYP2S1 Knockout Promotes Intestinal Tumor Growth in APC^Min/+ Mice and Its Clinical Significance
Yaqing Du, Yunxia Kuang, Xiuqiong Meng, Bobing Zheng, Qinru Chen, Qian Yan, Jiangchao Li
J. Cancer 2025; 16(10): 3128-3140. doi:10.7150/jca.111574
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Alpha-2-Macroglobulin and Signature Genes: Predictive Biomarkers for Prognosis and Immunotherapy in Clear Cell Renal Cell Carcinoma
Ming Li, Xin Luo, Renyu Zhou, Minting Liu, Guang Wang, Xiaotan Zhang
J. Cancer 2025; 16(10): 3141-3162. doi:10.7150/jca.113242
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Comprehensive Mendelian randomization and colocalization analysis of plasma proteomics to identify new therapeutic targets for bladder cancer
Jieming Zuo, Junhao Chen, Zhiyong Tan, Lingxiang Wen, Junxian Zhao, Yuanzhi Fu, Haifeng Wang, Shi Fu, Jiansong Wang
J. Cancer 2025; 16(10): 3163-3179. doi:10.7150/jca.116402
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The Traditional Chinese Medicine Formula Modified Wu Bao San Induces Cell Cycle Arrest and Apoptosis through Restoration of Retinoblastoma Protein Function and Inhibition of Aurora Kinase Activity
Chih-Jui Chang, Cheng-Chia Wu, Yi-Jen Hsieh, Jhong-Kuei Chen, Yen-Lun Kung, Wan-Ting Tsai, Hsuan-Shun Huang, Shinn-Zong Lin, Tsung-Jung Ho
J. Cancer 2025; 16(10): 3180-3191. doi:10.7150/jca.114495
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Differential diagnosis of benign and malignant ovarian tumors with combined tumor and systemic inflammation-related markers
Dan Song, Tingting Liu, Chao Han, Chu Zhang, Weimin Kong
J. Cancer 2025; 16(10): 3192-3201. doi:10.7150/jca.112768
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Prognostic Implications and Immune Landscape Analysis of Necroptosis-associated Gene Signatures in Acute Myeloid Leukemia
Zongsi Zhu, Bing Li, Ping Li
J. Cancer 2025; 16(10): 3202-3215. doi:10.7150/jca.113136
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Hypoxia upregulate TPM4 expression to strengthen epithelial-mesenchymal transition that promotes lymph node metastasis of papillary thyroid cancer
Zhufeng Li, Fuxin Li, Xunzhen Jiang, Yingxi Li, Lanning Jia, Xiaoning Wang, Yuanchao Liu, Ruoyu Jiang, Ke Zhao, Guangmei Pu, Yao Tian, Yizeng Wang, Xianghui He
J. Cancer 2025; 16(10): 3216-3234. doi:10.7150/jca.116524
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Risk Assessment of Precancers and Cancers in Women with Atypical Glandular Cells of Endocervical, Endometrial, and Unknown Origin
Chen Ding, Qin Liu, Xin Zhou, Qiuqin Zou, Wanrun Lin, Huijuan Zhang, Yudong Wang, Feng Zhou
J. Cancer 2025; 16(10): 3235-3243. doi:10.7150/jca.111557
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An integrated analysis identified mitochondrial ribosomal protein MRPL3 as a potential prognostic biomarker and therapeutic target in pancreatic cancer
Wuhan Yang, Huiyan Deng, Teng Pan, Xiaokun Zhang, Li Peng, Shubin Wang
J. Cancer 2025; 16(10): 3244-3260. doi:10.7150/jca.114067
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Neuregulin-1 correlates to early castration-resistant prostate cancer after prostate cancer patients receiving androgen deprivation therapy
Siyu Li, Wenyang Zhao, Dan Wang, Lei Chen, Yigeng Feng, Peng Sun
J. Cancer 2025; 16(10): 3261-3269. doi:10.7150/jca.112954
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Reviews

Predictive and Prognostic Biomarkers of Recurrence in Locoregional Colorectal Cancer
Alicia Sánchez Cendra, Leonel Pekarek, Linda Rocio Ospino, Yumna Dbouk, Sami Chnaiker, Ana Luengo, Tania Villamor, Amalia Corralo, Beatriz Pedrejon, Tatiana Pekarek, Silvestra Barrena-Blázquez, David Díaz-Pérez, Ana M Minaya-Bravo, Laura López-Gonzalez, Manuel Díez Alonso, Tomás Ratia Giménez, Alberto Gutiérrez-Calvo, Melchor Álvarez-Mon, Javier Cassinello Espinosa, Raúl Díaz-Pedrero, Miguel A Ortega
J. Cancer 2025; 16(10): 3024-3039. doi:10.7150/jca.111828
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The Dual Roles of Circular RNAs in Breast Cancer Distant Metastasis and Their Clinical Applications
Qing Bao, Huan Zhang, Pangzhou Chen, Song Wu, Yutian Zou, Huan Wang, Jingna Cao, Wen Zhou, Ziyun Guan, Hailin Tang
J. Cancer 2025; 16(10): 3270-3282. doi:10.7150/jca.111680
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