J Cancer
2022; 13(2):565-578.
doi:10.7150/jca.62033 This issueCite
Research Paper
RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer
Zongfeng Feng1,2*, Leyan Li2,3*, Qingwen Zeng1,2*, Yang Zhang1,2*, Yi Tu1,4, Wenzheng Chen1,2, Xufeng Shu1,2, Ahao Wu1,2, Jianbo Xiong1,2✉, Yi Cao1,2✉, Zhengrong Li1,2✉
1. Department of General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, China. 2. Laboratory of Digestive Surgery, Nanchang University, Nanchang, China. 3. Queen Mary School, Medical Department of Nanchang University, Nanchang, China. 4. Department of Pathology, the First Affiliated Hospital of Nanchang University, Nanchang, China. *These authors contributed equally to this work.
✉ Corresponding authors: Zhengrong Li, Department of General Surgery, the First Affiliated Hospital of Nanchang University. No. 17, Yongwai Zheng Road, Nanchang 330006, Jiangxi Province, People's Republic of China. E-mail: lzr13com; Yi Cao, Department of General Surgery, the First Affiliated Hospital of Nanchang University, No.17 Yongwai Zheng Road, Nanchang 330006, Jiangxi Province, People's Republic of China. E-mail: doctorcaoyicom; Jianbo Xiong, Department of General Surgery, the First Affiliated Hospital of Nanchang University, No.17 Yongwai Zheng Road, Nanchang 330006, Jiangxi Province, People's Republic of China. E-mail: Xiongjianbo2017com.More
Citation:
Feng Z, Li L, Zeng Q, Zhang Y, Tu Y, Chen W, Shu X, Wu A, Xiong J, Cao Y, Li Z. RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer. J Cancer 2022; 13(2):565-578. doi:10.7150/jca.62033. https://www.jcancer.org/v13p0565.htm
RNF114 (E3 ubiquitin ligase RING finger protein 114) was first identified as a zinc-binding protein that promotes psoriasis development; however, its role in gastric cancer is still unclear. We explored the relationship between RNF114 and gastric cancer using bioinformatics and molecular biology techniques. The results showed that RNF114 was highly expressed in gastric cancer and negatively correlated with the patient's prognosis. Functional assays suggested that RNF114 silencing suppressed the proliferation and metastasis of gastric cancer cells to a certain extent. Further studies showed that RNF114 expression was potentially targeted by miR-218-5p and methylation modification, and mediated downstream EGR1 (early growth response 1) degradation by the ubiquitylation approach. Together, the present results highlight the detrimental effects of RNF114 overexpression in gastric cancer and contribute to a better understanding of the mechanisms underlying RNF114 functionality.
Keywords: RNF114, EGR1, miR-218-5p, methylation, ubiquitylation, gastric cancer
Citation styles
APA
Feng, Z., Li, L., Zeng, Q., Zhang, Y., Tu, Y., Chen, W., Shu, X., Wu, A., Xiong, J., Cao, Y., Li, Z. (2022). RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer. Journal of Cancer, 13(2), 565-578. https://doi.org/10.7150/jca.62033.
ACS
Feng, Z.; Li, L.; Zeng, Q.; Zhang, Y.; Tu, Y.; Chen, W.; Shu, X.; Wu, A.; Xiong, J.; Cao, Y.; Li, Z. RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer. J. Cancer 2022, 13 (2), 565-578. DOI: 10.7150/jca.62033.
NLM
Feng Z, Li L, Zeng Q, Zhang Y, Tu Y, Chen W, Shu X, Wu A, Xiong J, Cao Y, Li Z. RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer. J Cancer 2022; 13(2):565-578. doi:10.7150/jca.62033. https://www.jcancer.org/v13p0565.htm
CSE
Feng Z, Li L, Zeng Q, Zhang Y, Tu Y, Chen W, Shu X, Wu A, Xiong J, Cao Y, Li Z. 2022. RNF114 Silencing Inhibits the Proliferation and Metastasis of Gastric Cancer. J Cancer. 13(2):565-578.
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