J Cancer 2021; 12(16):4873-4882. doi:10.7150/jca.58859

Review

Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells

Wenxiu Chen1,2, Shuna Liu1,2, Fang Wang1,2✉

1. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 210029.
2. National Key Clinical Department of Laboratory Medicine, Nanjing, China, 210029.

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Citation:
Chen W, Liu S, Wang F. Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells. J Cancer 2021; 12(16):4873-4882. doi:10.7150/jca.58859. Available from https://www.jcancer.org/v12p4873.htm

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Abstract

The discovery of many aberrant expressions of long non-coding RNAs (lncRNAs) in various cancers has focused attention on the effects of lncRNA on cancer cells themselves, including cell proliferation, growth inhibition, cell migration, cell immortality, vascular regeneration and cell viability. But with the increasing role of immunotherapy in cancer therapy, a large number of studies have revealed that the regulatory role of lncRNAs in immunity such as differentiation of immune cells can also influence the development and progression of cancer. In particular, recent publications have suggested that lncRNAs play critical roles in T-lymphocyte activation, proliferation, differentiation, function, apoptosis and metabolism. To elucidate the actual functions of lncRNAs at the molecular level of cancer pathogenesis, we summarize some of the current lncRNA regulatory mechanisms associated with T cell to discuss their effects in cancer in the hope of providing potential cancer therapeutic targets or cancer biomarkers. However, we all know that the differentiation and function of T cells is an extremely complex process that involves the expression and regulation of multiple lncRNAs. As a result, more regulatory mechanisms of lncRNAs need to be further studied.

Keywords: Long non-coding RNAs, cancer, T cell