J Cancer 2021; 12(6):1660-1668. doi:10.7150/jca.47344
Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP
1. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanjing Medical University, 262 Zhongshan North Road, Nanjing, 210000, China.
2. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nantong University, 6 Haierxiang North Road, Nantong, 226000, China.
3. Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai, 200011, China.
4. Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, 413 Zhaozhou Road, Shanghai, 200011, China.
Liu Y, Xu B, Liu M, Qiao H, Zhang S, Qiu J, Ying X. Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP. J Cancer 2021; 12(6):1660-1668. doi:10.7150/jca.47344. Available from https://www.jcancer.org/v12p1660.htm
Long non-coding RNAs (lncRNAs) play a pivotal role in the genesis and development of cancer. The role and molecular mechanisms of SNHG25 in epithelial ovarian cancer (EOC) have not been investigated. In the present study, we showed that SNHG25 expression was up-regulated in EOC tissues relative to normal ovarian tissues. In vitro, functional experiments demonstrated that high expression of SNHG25 promoted proliferation, migration and invasion, and decreased apoptosis, in ovarian cancer cell lines. In vivo, downregulation of SNHG25 inhibited the growth (tumor volume) of subcutaneous xenografts in nude mice. High-throughput sequencing and western blot analysis showed a significant decrease in the expression of COMP mRNA and protein in SNHG25 knockdown compared to control ovarian cancer cells. These data suggest that SNHG25 promotes EOC progression by regulating COMP, serving as a potential biomarker for EOC.
Keywords: lncRNA SNHG25, epithelial ovarian cancer, proliferation, metastasis, COMP