Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor

Lai, Jianguo; Lin, Jinjiang; Wang, Hongli; Sun, Yi; Li, Yudong; Tian, Huan; Shen, Shiyu; Tan, Cui; Liu, Huanhuan; Yu, Fengyan

doi:10.7150/jca.49441

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J Cancer 2021; 12(3):799-806. doi:10.7150/jca.49441 This issue Cite

Research Paper

Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor

Jianguo Lai^1,4,6†, Jinjiang Lin^2†, Hongli Wang^3,4†, Yi Sun^1,4, Yudong Li^1,4, Huan Tian^1,4, Shiyu Shen^3,4, Cui Tan^4,5, Huanhuan Liu^1,4,7, Fengyan Yu^{1,4 ✉}

1. Department of Breast Surgery, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
2. Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
3. Diagnostic Department, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
4. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
5. Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
6. Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Science, Guangzhou, Guangdong, China.
7. Department of Plastic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
†These authors contributed equally to this study.

Citation:

Lai J, Lin J, Wang H, Sun Y, Li Y, Tian H, Shen S, Tan C, Liu H, Yu F. Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor. J Cancer 2021; 12(3):799-806. doi:10.7150/jca.49441. https://www.jcancer.org/v12p0799.htm

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Abstract

Purpose: To establish a preoperative nomogram incorporating morphological and dynamic contrast-enhanced (DCE) features to individually predict the risk of malignancy in patients with breast tumor.

Methods A total of 447 consecutive female patients who were divided into the primary cohort (n=326) and the validation cohort (n=121) were enrolled between March 2015 to January 2018. Univariate and multivariate logistic regression analyses were used to identify the potential independent indicators of malignancy. An MRI-based nomogram integrating morphological features and kinetic curves was developed to achieve individualized risk prediction of malignancy in patients with breast masses. The discrimination, calibration ability and clinical utility of the MRI-based model were assessed using C-index, calibration curve and decision curve analysis.

Results: Age, tumor size, margin, internal enhancement characteristics, and kinetic curve were confirmed as the independent predictors of malignancy. The AUC of MRI-based nomogram was 0.940 (95% CI: 0.911-0.970) and 0.894 (95% CI: 0.816-0.974) in the primary cohort and validation cohort, respectively. 447 patients were subdivided into the low-risk group (n=107) and high-risk group (n=340) based on the optimal cut-off value of 21.704. The high-risk patients had a higher likelihood of harboring malignancy.

Conclusion: The MRI-based nomogram can be used to achieve an accurate individualized risk prediction of malignancy and reduce unnecessary breast biopsy.

Keywords: Breast, Nomogram, Magnetic resonance imaging, Diagnosis

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APA

Lai, J., Lin, J., Wang, H., Sun, Y., Li, Y., Tian, H., Shen, S., Tan, C., Liu, H., Yu, F. (2021). Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor. Journal of Cancer, 12(3), 799-806. https://doi.org/10.7150/jca.49441.

ACS

Lai, J.; Lin, J.; Wang, H.; Sun, Y.; Li, Y.; Tian, H.; Shen, S.; Tan, C.; Liu, H.; Yu, F. Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor. J. Cancer 2021, 12 (3), 799-806. DOI: 10.7150/jca.49441.

NLM

CSE

Lai J, Lin J, Wang H, Sun Y, Li Y, Tian H, Shen S, Tan C, Liu H, Yu F. 2021. Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor. J Cancer. 12(3):799-806.

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