J Cancer 2021; 12(1):224-231. doi:10.7150/jca.49203

Review

The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

Xuewen Tan1#, Haifeng Jiang1#, Yilong Fang1, Dafei Han1, Yawei Guo1, Xinming Wang2, Xun Gong1, Wenming Hong2, Jiajie Tu1✉, Wei Wei1✉

1. Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, China.
2. The First Affiliated Hospital of Anhui Medical University.
#These authors equally contributed to this paper.

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Citation:
Tan X, Jiang H, Fang Y, Han D, Guo Y, Wang X, Gong X, Hong W, Tu J, Wei W. The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker. J Cancer 2021; 12(1):224-231. doi:10.7150/jca.49203. Available from https://www.jcancer.org/v12p0224.htm

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Abstract

Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.

Keywords: GAS5, miRNA, glioma, chemosensitivity