J Cancer 2020; 11(10):2981-2992. doi:10.7150/jca.39651

Research Paper

Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes

Jianwen Hu1, Yongchen Ma2, Ju Ma1, Shanwen Chen1, Xiaoqian Zhang1, Shihao Guo1, Zhihao Huang1, Taohua Yue1, Yanpeng Yang1, Yingze Ning1, Jing Zhu1, Pengyuan Wang1, Xin Wang1, Guowei Chen, Yucun Liu

1. Department of General Surgery, Peking University First Hospital, Beijing, 100034, PR China.
2. Endoscopy Center, Peking University First Hospital, Beijing, 100034, PR China.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Hu J, Ma Y, Ma J, Chen S, Zhang X, Guo S, Huang Z, Yue T, Yang Y, Ning Y, Zhu J, Wang P, Wang X, Chen G, Liu Y. Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes. J Cancer 2020; 11(10):2981-2992. doi:10.7150/jca.39651. Available from http://www.jcancer.org/v11p2981.htm

File import instruction

Abstract

Since the theory of seed and soil was put forward, people have increasingly recognized that the tumour microenvironment is an important regulator of tumour progression and therapeutic response. Among them, M2-type macrophages (M2, as the major macrophage subtype in the tumour foci) have important promoting effects on various biological behaviours. Secreted protein acidic and rich in cysteine (SPARC) is an important anti-tumour component in the microenvironment of gastric cancer. This study shows that macrophages are an important source of the SPARC and that SPARC overexpression in M2 can reduce M2-mediated promoting proliferation, migration and anti-apoptotic effects in gastric cancer. Additionally, the AKT/mTOR signalling pathways may participate in the malignant process.

Keywords: tumour-associated macrophages, SPARC, gastric cancer, proliferation, migration, apoptosis