J Cancer 2020; 11(10):2981-2992. doi:10.7150/jca.39651
Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes
1. Department of General Surgery, Peking University First Hospital, Beijing, 100034, PR China.
2. Endoscopy Center, Peking University First Hospital, Beijing, 100034, PR China.
Hu J, Ma Y, Ma J, Chen S, Zhang X, Guo S, Huang Z, Yue T, Yang Y, Ning Y, Zhu J, Wang P, Wang X, Chen G, Liu Y. Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes. J Cancer 2020; 11(10):2981-2992. doi:10.7150/jca.39651. Available from http://www.jcancer.org/v11p2981.htm
Since the theory of seed and soil was put forward, people have increasingly recognized that the tumour microenvironment is an important regulator of tumour progression and therapeutic response. Among them, M2-type macrophages (M2, as the major macrophage subtype in the tumour foci) have important promoting effects on various biological behaviours. Secreted protein acidic and rich in cysteine (SPARC) is an important anti-tumour component in the microenvironment of gastric cancer. This study shows that macrophages are an important source of the SPARC and that SPARC overexpression in M2 can reduce M2-mediated promoting proliferation, migration and anti-apoptotic effects in gastric cancer. Additionally, the AKT/mTOR signalling pathways may participate in the malignant process.
Keywords: tumour-associated macrophages, SPARC, gastric cancer, proliferation, migration, apoptosis