J Cancer 2019; 10(27):6837-6847. doi:10.7150/jca.36430

Research Paper

RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT

Zhen Chen1*, Wenjing Wu2*, Yongsheng Huang1, Limin Xie1, Yu Li1, Hengxing Chen1, Wenjia Li1, Dong Yin1✉, Kaishun Hu1✉

1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China
2. Department of Breast Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China
*These authors have contributed equally to this work.

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Citation:
Chen Z, Wu W, Huang Y, Xie L, Li Y, Chen H, Li W, Yin D, Hu K. RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. J Cancer 2019; 10(27):6837-6847. doi:10.7150/jca.36430. Available from http://www.jcancer.org/v10p6837.htm

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Abstract

Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is an RCC1 family member and plays an essential role in mitosis. However, the roles of RCC2 in breast cancer are still unclear. In this study, RCC2 was found to exert oncogenic activities in breast cancer. Samples of breast cancer tissue revealed an increased level of RCC2 and a high level of RCC2 was associated with poor overall survival rate of breast cancer patients. Overexpression of RCC2 significantly enhanced cell proliferation and migration abilities of breast cancer cells in vitro and in vivo. Mechanistically, RCC2 induced epithelial-mesenchymal transition (EMT) through the activation of Wnt signaling pathway. Collectively, our study indicates that RCC2 contributes to breast cancer progression and functions as an important regulator of EMT through the activation of Wnt signaling.

Keywords: Regulator of Chromosome Condensation 2 (RCC2), Breast cancer, Epithelial-Mesenchymal Transition (EMT), Wnt signaling pathway