J Cancer 2019; 10(26):6584-6593. doi:10.7150/jca.32407

Research Paper

Prognostic value of ABO blood group in a Chinese population in Northwest China region with curatively resected rectal cancer

Jiangpeng Wei1*, Ying Zhang2*, Jianyong Zheng1*, Xiangying Feng1*, Xiaomin Wang1, Kunli Du1, Weizhong Wang1, Guosheng Wu1, Qingchuan Zhao1, Daiming Fan1, Xiaohua Li1✉

1. State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China.
2. Department of radiotherapy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
* These authors contributed equally to this work.

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Citation:
Wei J, Zhang Y, Zheng J, Feng X, Wang X, Du K, Wang W, Wu G, Zhao Q, Fan D, Li X. Prognostic value of ABO blood group in a Chinese population in Northwest China region with curatively resected rectal cancer. J Cancer 2019; 10(26):6584-6593. doi:10.7150/jca.32407. Available from http://www.jcancer.org/v10p6584.htm

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Abstract

A positive association between the ABO blood types and survival has been suggested in several malignancies. However, little is known about the relationship between ABO blood group and survival in rectal cancer patients. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of a Chinese population in Northwest China region with curatively resected rectal cancer. We retrospectively analyzed 1613 consecutive patients who underwent curative surgery for rectal cancer between June, 2011 and December, 2016. The relationship between the ABO blood types and overall survival (OS) was analyzed. The median follow-up period of the 1613 rectal cancer patients was 69.6 months with 1427 alive. There was a significance difference of survival among ABO blood groups (P=0.007). The mean overall survival (OS) of the blood type B patients was 70.8 months, O was 64.3, whereas the mean OS of the AB and A blood type patients was significantly lower, 58.4 months and 59.7 months respectively (P=0.007, log-rank test). Compared with patients with A and AB blood types, patients with blood type B and O were more likely to have better survival(P=0.001). A blood groups were associated with significantly decreased overall survival in rectal cancer patients (hazard ratio = 1.263; 95% confidence interval = 0.776-2.054, P =0.010). In order to confirm our above results, we performed the same investigation in an independent cohort from another hospital of 505 Chinese patients and get the similar results. Our study showed that ABO blood group is associated with survival in Northwest Chinese patients with rectal cancer and the blood type B and O were favourable prognostic factors for patients with rectal cancer.

Keywords: ABO blood group, rectal cancer, retrospective cohort, survival