J Cancer 2019; 10(24):6154-6160. doi:10.7150/jca.31752

Review

Potential Therapeutic Roles of Exosomes in Multiple Myeloma: A Systematic Review

Mengzhen Li2*, Bing Xia2*, Yi Wang2,3*, M. James You3✉, Yizhuo Zhang1,2✉

1. Department of Pediatric oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, China
2. Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer; 300060, China
3. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
*Mengzhen Li, Bing Xia and Yi Wang are co-first authors and contributed equally to this work.

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Citation:
Li M, Xia B, Wang Y, You MJ, Zhang Y. Potential Therapeutic Roles of Exosomes in Multiple Myeloma: A Systematic Review. J Cancer 2019; 10(24):6154-6160. doi:10.7150/jca.31752. Available from http://www.jcancer.org/v10p6154.htm

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Abstract

Multiple myeloma (MM) is the second most prevalent hematological malignancy. In spite of the remarkable progress in understanding the biology and therapy of MM, curing this disease remains difficult, which calls for more effective treatment strategies. As vital communicators between different cells, exosomes have been verified to be crucial to cancer diagnosis, treatment, and prognosis. Exosomes in MM patients show a different expression profile compared with those in healthy individuals. In this review, we summarize potential therapy roles exosomes may play in MM. The specific expression of certain components in exosomes may provide therapeutic targets. Moreover, tumor-derived exosomes and their modified products can be developed into vaccines for anti-tumor immunity. In addition, the natural nano structure of exosomes makes them excellent carriers for drug delivery. Thus, a more rigorous investigation into exosomes will pave the way for novel tumor therapies in MM patients.

Keywords: exosomes, multiple myeloma, potential therapeutic target, miRNA, protein, drug delivery