J Cancer 2019; 10(18):4350-4356. doi:10.7150/jca.35205

Review

MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment

Yanping Su1, Ye Qiu2, Zhidong Qiu3, Peng Qu4✉

1. Department of Histology and embryology, Shangdong First Medical University & Shangdong Academy of Medical Sciences, Taian, Shangdong, China.
2. National Engineering Lab for Druggable gene and protein screening, Northeast Normal University, Changchun, Jilin, China.
3. Department of pharmacy, Changchun University of Chinese Medicine, Changchun, Jilin, China.
4. National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

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Citation:
Su Y, Qiu Y, Qiu Z, Qu P. MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment. J Cancer 2019; 10(18):4350-4356. doi:10.7150/jca.35205. Available from http://www.jcancer.org/v10p4350.htm

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Abstract

Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to manipulate immune response in the diseases. MicroRNA (miRNAs) as one short noncoding RNAs, are involved in regulating cell proliferation, differentiation and maturation. However, it needs to be further studied how miRNAs mediate the development and function of MDSC in association with cancer and other diseases. In the review, we report and discuss recent studies that miRNAs networks regulate the differentiation, expansion and suppression function of MDSCs in tumor microenvironment or other diseases through different signaling pathways. Those studies may provide one novel potential approach for tumor immunotherapy.

Keywords: MicroRNA, Myeloid-derived suppressor cells, Tumor