1. Department of Hematological Oncology, Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China 2. Department of Pathology, Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China 3. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China *The first two authors contributed equally to this work.
✉ Corresponding authors: Hailin Tang, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. E-mail: tanghlorg.cn; Phone No.:+86-20-87342438 or Shu-xia Lin, Department of Pathology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. E-mail: lisuzdcom; Phone No.:+86-20-87342462More
Citation:
Wang H, Hu Wm, Xia Zj, Liang Y, Lu Y, Lin Sx, Tang H. High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens. J Cancer 2019; 10(14):3239-3245. doi:10.7150/jca.30102. https://www.jcancer.org/v10p3239.htm
The prognostic significance of tumor-associated macrophages (TAMs) in multiple myeloma (MM) in the era of novel drugs remains unclear. CD163 expression was detected by immunohistochemistry to determine the number of TAMs in 198 MM patients receiving bortezomib-based regimens and the data were used to evaluate its relevance with clinical characteristics, treatment response, and prognosis. Patients with high levels of infiltrated CD163+ TAMs (>55/HPF) at diagnosis tended to have more adverse clinical characteristics. Patients with high CD163+ TAM content (>55/HPF) at diagnosis had worse progression-free survival (PFS) (P<0.001) and overall survival (OS) (P<0.001),and achieved lower complete remission (CR)/near-CR rate (P<0.001), than patients with low CD163+ TAM levels. Multivariate analysis revealed that CD163+ TAM content was an independent adverse prognostic factor for PFS and OS. Our data indicated that CD163+ TAM content at diagnosis is a powerful predictor of prognosis for MM in the era of novel drugs, and this discovery offers new insight into potential therapeutic strategies.
Wang, H., Hu, W.m., Xia, Z.j., Liang, Y., Lu, Y., Lin, S.x., Tang, H. (2019). High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens. Journal of Cancer, 10(14), 3239-3245. https://doi.org/10.7150/jca.30102.
ACS
Wang, H.; Hu, W.m.; Xia, Z.j.; Liang, Y.; Lu, Y.; Lin, S.x.; Tang, H. High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens. J. Cancer 2019, 10 (14), 3239-3245. DOI: 10.7150/jca.30102.
NLM
Wang H, Hu Wm, Xia Zj, Liang Y, Lu Y, Lin Sx, Tang H. High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens. J Cancer 2019; 10(14):3239-3245. doi:10.7150/jca.30102. https://www.jcancer.org/v10p3239.htm
CSE
Wang H, Hu Wm, Xia Zj, Liang Y, Lu Y, Lin Sx, Tang H. 2019. High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens. J Cancer. 10(14):3239-3245.
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