J Cancer 2019; 10(13):3046-3053. doi:10.7150/jca.30587

Research Paper

Expression of WDR79 is associated with TP53 mutation and poor prognosis in surgically resected non-small cell lung cancer

Jinwu Peng1,3,4, Yuting Zhan2, Juan Feng2, Songqing Fan2✉, Hongjing Zang2✉

1. Department of Pathology, Xiangya Basic Medical School, Central South University, Changsha 410013, Hunan, China
2. Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China
3. Department of Pathology, Xiangya Changde Hospital, Changde 415000, Hunan, China
4. Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China

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Citation:
Peng J, Zhan Y, Feng J, Fan S, Zang H. Expression of WDR79 is associated with TP53 mutation and poor prognosis in surgically resected non-small cell lung cancer. J Cancer 2019; 10(13):3046-3053. doi:10.7150/jca.30587. Available from http://www.jcancer.org/v10p3046.htm

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Abstract

Non-small cell lung cancer (NSCLC) represents a major health burden globally. WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family. WDR79 is a highly conserved and natural antisense transcript to TP53 gene and involved in carcinogenesis of various types of cancer. Whether the alterations of WDR79 protein expression are associated with TP53 mutation and clinicopathological and prognostic implications in the patients with surgically resected NSCLC have not been reported. The purposes of the present study are to investigate the association between the expression of WDR79 and mutant p53 (mtp53) and clinicopathological features in NSCLC by immunohistochemistry. The results showed that positive expression of WDR79 (58.8%, 170/289) and mtp53 (48.1%, 139/289) in NSCLC was significantly higher than that in non-cancerous control lung tissues (5.7%, 3/53 and 1.9%, 1/53, respectively). There was a significantly higher positive percentage of WDR79 expression in NSCLC with lymph node metastasis. The statistically positive correlation between WDR79 and mtp53 expression (r = 0.212, P=0.014) was identified by Spearman's rank correlation analysis. Kaplan-Meier survival curve analysis indicated that positive expression of WDR79 and common positive expression of WDR79 and mtp53 were correlated with poor overall survival rates in NSCLC patients (P = 0.029 and P = 0.041, respectively). Multivariate Cox regression analysis further identified that WDR79 positive expression was an independent unfavorable prognostic factor of NSCLC (P = 0.034). Taken together, positive expression of WDR79 proteins may be related with TP53 mutations and act as valuable independent biomarker to predict poor prognosis of patients with surgically resected NSCLC.

Keywords: Non-small cell lung cancer, WDR79, TP53, mutant, prognosis