J Cancer 2019; 10(13):2935-2941. doi:10.7150/jca.31134

Research Paper

Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population

Weiwei Hu1#, Chih-Hsin Tang2,3,4#, Hsien-Te Chen5,6, Jin Zhao7, Lulu Jin7, Le Kang7, Yueming Wu1, Pengqing Ying1, Chao-Qun Wang8, Chen-Ming Su7✉

1. Department of Thoracic Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
2. School of Medicine, China Medical University, Taichung, Taiwan
3. Chinese Medicine Research Center, China Medical University, Taichung, Taiwan
4. Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan
5. Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan
6. Department of Orthopaedic Surgery, China Medical University Hospital, Taichung, Taiwan
7. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
8. Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
# These authors have contributed equally to this work

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Citation:
Hu W, Tang CH, Chen HT, Zhao J, Jin L, Kang L, Wu Y, Ying P, Wang CQ, Su CM. Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population. J Cancer 2019; 10(13):2935-2941. doi:10.7150/jca.31134. Available from http://www.jcancer.org/v10p2935.htm

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Abstract

Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatment. The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. Patients with lung cancer with higher serum Ang2 levels have significantly poorer survival than patients with lower serum Ang2 levels. We explored the effects of Ang2 single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. We used lung cancer tissue and serum samples to measure Ang2 expression in a Chinese Han population. Five Ang2 SNPs (rs2442598, rs734701, rs1823375, 11137037, and rs12674822) were analyzed using TaqMan SNP genotyping in 695 patients with lung cancer and 900 cancer-free controls. Carriers of the variant GT allele of rs12674822 had a higher risk of lung cancer than wild-type (GG) carriers, while the presence of the CC genotype at rs11137037 was associated with higher clinical stage disease compared with having the AA genotype. Our study is the first to document a correlation between Ang2 polymorphisms and lung cancer development and progression in people of Chinese Han ethnicity.

Keywords: Angiopoietin-2, lung cancer, polymorphism