J Cancer 2017; 8(12):2205-2211. doi:10.7150/jca.19173
The Neutrophil-Lymphocyte Ratio Predicts Recurrence of Cervical Intraepithelial Neoplasia
1. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Korea
2. Department of Medicine, Pusan National University Graduate School, Busan, Korea
3. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital
4. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea
5. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea
6. Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea
7. Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea, Seoul, Korea
8. Department of Obstetrics and Gynecology, Keimyung University, School of Medicine, Daegu, Korea
9. Department of Obstetrics and Gynecology, Catholic University of Daegu, School of Medicine, Daegu, Korea
10. Department of Obstetrics and Gynecology, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea
#Chun S and Shin K contributed equally to the study.
* Kim HY and Kim KH carry out equal roles as co-corresponding authors.
Chun S, Shin K, Kim KH, Kim HY, Eo W, Lee JY, Namkung J, Kwon SH, Koh SB, Kim HB. The Neutrophil-Lymphocyte Ratio Predicts Recurrence of Cervical Intraepithelial Neoplasia. J Cancer 2017; 8(12):2205-2211. doi:10.7150/jca.19173. Available from http://www.jcancer.org/v08p2205.htm
OBJECTIVE: The purpose of the present study was to determine the prognostic significance of the neutrophil-lymphocyte ratio (NLR) in recurrence of cervical intraepithelial neoplasia (CIN).
METHODS: We evaluated the NLR as a prognostic marker in the entire cohort of 230 patients who had undergone surgical resection and were diagnosed with CIN. Subjects were categorized into two different groups based on the NLR (NLR-high and NLR-low) using cutoff values determined by receiver operating characteristic (ROC) analysis. The primary research objective for this study was to validate the impact of the NLR on recurrence-free survival (RFS) in patients with CIN. The secondary objective was to evaluate the impact of other hematologic parameters on RFS in CIN patients.
RESULTS: Using the entire cohort, the most appropriate NLR cut-off value for CIN recurrence selected on the ROC curve was 2.1. The NLR-low and NLR-high groups included 167 (72.6%) and 63 patients (27.4%), respectively. According to Kaplan-Meier analysis, RFS rates during the entire follow-up period were considerably lower in the NLR-high group than in the NLR-low group (P = 0.0125). In multivariate survival analysis using Cox proportional hazard model, we identified the NLR, absolute eosinophil count (AEC), hemoglobin concentration, and mean corpuscular volume (MCV) as valuable prognostic factors that impact RFS.
CONCLUSIONS: The NLR is an independent prognosticator for RFS following surgical resection in CIN patients. We also found that the AEC, hemoglobin level, and MCV were strongly associated with RFS, as determined by multivariate analysis using a Cox model. These hematological parameters might provide additional prognostic value beyond that offered by standard clinicopathologic parameters.
Keywords: Cervical Intraepithelial Neoplasia, Eosinophil, Lymphocyte, Neutrophil, Recurrence.