J Cancer 2017; 8(6):1025-1029. doi:10.7150/jca.16491 This issue

Research Paper

A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio

Zihui Tan1,2,3*, Man Zhang4*, Qiang Han5*, Jing Wen1,2,3, Kongjia Luo1,2,3, Peng Lin1,2,3, Lanjun Zhang1,2,3, Hong Yang1,2,3, Jianhua Fu1,2,3✉

1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.
2. Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China.
3. Guangdong Esophageal Cancer Institute, Guangzhou, China.
4. Department of Ultrasound, The third affiliated hospital, SunYat-senUniversity,600 Tianhe Road, Guangzhou, China.
5. Department of Thoracic Surgery, The fifth affiliated hospital, SunYat-senUniversity, Zhuhai, China.
* These authors contributed equally to this work

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Tan Z, Zhang M, Han Q, Wen J, Luo K, Lin P, Zhang L, Yang H, Fu J. A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio. J Cancer 2017; 8(6):1025-1029. doi:10.7150/jca.16491. Available from https://www.jcancer.org/v08p1025.htm

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Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients.

Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers.

Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0.003), sex(p=0.030), tumor length (p=0.043), pT status(p<0.001) and pN status(p<0.001). Pearson's correlation indicated that the FAR were positively associated with the serum C-reactive protein (CRP) ( r=0.583, p<0.001), and the NLR ( r=0.316, p<0.001). Multivariate analysis indicated that age, tumor grade, pT status, pN status and preoperative FAR were independent prognostic factors in patients with ESCC.

Conclusions: Preoperative FAR was an independent prognostic factor in ESCC patients. Lower FAR may improve OS of ESCC patients.

Keywords: esophageal squamous cell carcinoma, blood tool, fibrinogen, albumin