The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma

Wei, Minghao; Zhou, Gaoyang; Chen, Lian; Zhang, Yufu; Ma, Wei; Gao, Li; Gao, Guodong

doi:10.7150/jca.96365



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2024; 15(12):3857-3872. doi:10.7150/jca.96365 This issue Cite

Research Paper

The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma

Minghao Wei^1,3,*, Gaoyang Zhou^1,*, Lian Chen², Yufu Zhang¹, Wei Ma¹, Li Gao^1,✉, Guodong Gao^1,✉

1. Department of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710038, China.
2. Department of Neurosurgery, the Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110001 China.
3. Department of Neurosurgery Ward II, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China.
*These authors have contributed equally to this work.

Citation:

Wei M, Zhou G, Chen L, Zhang Y, Ma W, Gao L, Gao G. The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma. J Cancer 2024; 15(12):3857-3872. doi:10.7150/jca.96365. https://www.jcancer.org/v15p3857.htm

Other styles

Abstract

Cancer is a destructive disease and is currently the leading cause of major threats to human health. PLBD1 is a transcription factor that regulates phospholipid metabolism, but its role in tumors is unknown. We assessed pan-cancer expression, methylation, and mutation data of PLBD1 by multiple databases to investigate its clinical prognostic value. In addition, we examined the pan-cancer immunological signature of PLBD1, particularly in gliomas. Furthermore, we assessed the impact of PLBD1 knockdown on the proliferation and invasive capacity of glioma cells by in vitro experiments. Our results suggest that PLBD1 is highly expressed in multiple types of cancers, and it can serve as an independent prognostic factor for gliomas. In addition, we found that the epigenetic alterations of PLBD1 were highly heterogeneous in a variety of cancers, including gliomas, and that its high methylation was associated with poor prognosis in a broad range of cancers. Immunological profiling demonstrated that PLBD1 was significantly associated with immune cell infiltration and multiple immune checkpoints in gliomas and is a potential biomarker for gliomas. Furthermore, cellular experiments showed that knockdown of PLBD1 significantly inhibited the proliferation and invasive ability of glioma cells. In conclusion, PLBD1 is a potential tumor prognostic biomarker and immunotherapeutic target that plays a crucial role in glioma cell proliferation, invasion and immunotherapy.

Keywords: PLBD1, Glioma, Immunotherapy, Immune microenvironment, Pan-cancer

Citation styles

APA

Wei, M., Zhou, G., Chen, L., Zhang, Y., Ma, W., Gao, L., Gao, G. (2024). The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma. Journal of Cancer, 15(12), 3857-3872. https://doi.org/10.7150/jca.96365.

ACS

Wei, M.; Zhou, G.; Chen, L.; Zhang, Y.; Ma, W.; Gao, L.; Gao, G. The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma. J. Cancer 2024, 15 (12), 3857-3872. DOI: 10.7150/jca.96365.

NLM

CSE

Wei M, Zhou G, Chen L, Zhang Y, Ma W, Gao L, Gao G. 2024. The prognostic and immune significance of PLBD1 in pan-cancer and its roles in proliferation and invasion of glioma. J Cancer. 15(12):3857-3872.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.