ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2024; 15(12):3760-3765. doi:10.7150/jca.96413 This issue Cite
Research Paper
Socioeconomic status, individual behaviors and risk for Lymphomas: a Mendelian randomization study
1. Research Center of Health Policy and Health Management, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.
2. Department of Personnel, Suqian First Hospital, Suqian 223800, Jiangsu, China.
3. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
4. Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu, China.
5. Blood Diseases Institute, Xuzhou Medical University, Xuzhou 221006, Jiangsu, China.
6. Key Laboratory of Bone Marrow Stem Cell, Xuzhou 221006, Jiangsu, China.
7. Cell Research and Translational Medicine Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu, China.
† Joint first authors.
Abstract
Background: The association of socioeconomic status and individual behavior (SES/IB) with human health is receiving increasing attention. However, the causal effects between SES/IB and lymphomas remain unclear.
Methods: A two-sample Mendelian randomization (MR) study was used to assess the causal effects of 25 SES/IB traits (dietary habits, physical activity, smoking/drinking behaviors, sleeping behaviors, leisure sedentary behaviors, risky behaviors, and reproductive behaviors) on six distinct types of lymphomas, including Hodgkin lymphoma (HL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), mature T/NK-cell lymphomas, marginal zone B-cell lymphoma (MZL), and mantle cell lymphoma (MCL). The inverse variance weighted (IVW) method was the primary approach used for the MR analysis. A series of sensitivity analyses were also conducted to ensure the robustness of the findings.
Results: Two-sample MR revealed six SES/IB traits causally associated with lymphomas, including relative fat intake, drive time, television watching time, computer use time, vigorous physical activity, and number of children ever born. After false discovery rate (FDR) correction, the causal associations between longer television watching time and DLBCL (OR: 4.048, 95% CI: 1.688 to 9.708, Pfdr=0.009), and the number of children ever born with both FL (OR: 0.008, 95% CI: 1.412E-04 to 0.484, Pfdr=0.021) and DLBCL (OR: 0.001, 95% CI:1.587E-05 to 0.081, Pfdr=0.002) were identified.
Conclusions: These findings suggest that certain lifestyle and behavioral factors have a measurable impact on specific lymphoma types.
Keywords: Individual behavior, Lymphomas, Mendelian randomization, Socioeconomic status.
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