Journal of Cancer
ISSN: 1837-9664
Global reach, higher impact
J Cancer 2024; 15(11):3272-3283. doi:10.7150/jca.94669 This issue Cite
Review
Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond
Key Laboratory of Translational Cancer Stem Cell Research, Department of Pathophysiology, Hunan Normal University School of Medicine, Changsha, Hunan, China.
Citation:
Xu X, Wang X, Zheng Z, Guo Y, He G, Wang Y, Fu S, Zheng C, Deng X. Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond. J Cancer 2024; 15(11):3272-3283. doi:10.7150/jca.94669. https://www.jcancer.org/v15p3272.htm
Other stylesAbstract
Despite advances in the treatment of breast cancer, the disease continues to exhibit high global morbidity and mortality. The importance of neutrophils in cancer development has been increasingly recognized. Neutrophil extracellular traps (NETs) are web-like structures released into the extracellular space by activated neutrophils, serving as a potential antimicrobial mechanism for capturing and eliminating microorganisms. The roles played by NETs in cancer development have been a subject of intense research in the last decade. In breast cancer, current evidence suggests that NETs are involved in various stages of cancer development, particularly during metastasis. In this review, we try to provide an updated overview of the roles played by NETs in breast cancer metastasis. These include: 1) facilitating systemic dissemination of cancer cells; 2) promoting cancer-associated inflammation; 3) facilitating cancer-associated thrombosis; 4) facilitating pre-metastatic niche formation; and 5) awakening dormant cancer cells. The translational implications of NETs in breast cancer treatment are also discussed. Understanding the relationship between NETs and breast cancer metastasis is expected to provide important insights for developing new therapeutic strategies for breast cancer patients.
Keywords: Neutrophil extracellular trap (NET), Breast cancer, Tumor immunity, Therapeutic target, Tumor microenvironment
Citation styles
APA
Xu, X., Wang, X., Zheng, Z., Guo, Y., He, G., Wang, Y., Fu, S., Zheng, C., Deng, X. (2024). Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond. Journal of Cancer, 15(11), 3272-3283. https://doi.org/10.7150/jca.94669.
ACS
Xu, X.; Wang, X.; Zheng, Z.; Guo, Y.; He, G.; Wang, Y.; Fu, S.; Zheng, C.; Deng, X. Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond. J. Cancer 2024, 15 (11), 3272-3283. DOI: 10.7150/jca.94669.
NLM
Xu X, Wang X, Zheng Z, Guo Y, He G, Wang Y, Fu S, Zheng C, Deng X. Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond. J Cancer 2024; 15(11):3272-3283. doi:10.7150/jca.94669. https://www.jcancer.org/v15p3272.htm
CSE
Xu X, Wang X, Zheng Z, Guo Y, He G, Wang Y, Fu S, Zheng C, Deng X. 2024. Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond. J Cancer. 15(11):3272-3283.
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