The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer

Li, Qin; Chen, Mengqi; Xiao, Lamei; Zhao, Huaqin

doi:10.7150/jca.87397

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2023; 14(16):2990-2997. doi:10.7150/jca.87397 This issue Cite

Research Paper

The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer

Qin Li^1*✉, Mengqi Chen^2*, Lamei Xiao², Huaqin Zhao²

1. Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
2. The Second People's Hospital of Deyang City, Deyang, 618000, Sichuan, China.
^* These authors contributed equally to this work.

Citation:

Li Q, Chen M, Xiao L, Zhao H. The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer. J Cancer 2023; 14(16):2990-2997. doi:10.7150/jca.87397. https://www.jcancer.org/v14p2990.htm

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Abstract

Background: In recent years, several studies have investigated the relationship between platelet to lymphocyte ratio (PLR) and the prognosis of patients with laryngeal cancer, but the results remain controversial. This study aimed to evaluate the prognostic significance of pretreatment PLR in patients with laryngeal cancer.

Methods: Up to July 2023, we searched PubMed, PubMed Central, Web of Science, Embase, CNKI and Wanfang databases to collect relevant articles evaluating the relationship between PLR and the prognosis of laryngeal cancer. The pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated using the random effect-model.

Results: A total of 14 included studies involving 3220 patients with laryngeal cancer were included. The combined results suggested that elevated PLR was associated with poorer overall survival (HR = 2.21, 95% CI, 1.67 - 2.93, p < 0.001), progression-free survival (HR = 2.54, 95% CI, 1.76-3.66, p < 0.001), recurrence-free survival (HR = 1.87, 95% CI,1.45 - 2.42, p < 0.001), and disease-free survival (HR = 1.46, 95% CI, 1.08-1.98, p < 0.001). Subgroup analysis further confirmed that pretreatment PLR was an independent predictor of OS in laryngeal cancer patients.

Conclusion: Higher pretreatment PLR is strongly related to poor prognosis of laryngeal cancer patients. This indicates that PLR has the potential to serve as a valuable biomarker for predicting the prognosis of laryngeal cancer. However, further validations in large prospective cohorts are necessary to confirm its clinical utility and reliability.

Keywords: platelet to lymphocyte ratio, laryngeal cancer, prognosis, survival outcome

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APA

Li, Q., Chen, M., Xiao, L., Zhao, H. (2023). The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer. Journal of Cancer, 14(16), 2990-2997. https://doi.org/10.7150/jca.87397.

ACS

Li, Q.; Chen, M.; Xiao, L.; Zhao, H. The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer. J. Cancer 2023, 14 (16), 2990-2997. DOI: 10.7150/jca.87397.

NLM

CSE

Li Q, Chen M, Xiao L, Zhao H. 2023. The prognostic role of the preoperative platelet to lymphocyte ratio in laryngeal cancer. J Cancer. 14(16):2990-2997.

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