Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora

Dong, Yushan; Chen, Jingyu; Sun, Heng; Chen, Yuhan; Jiao, Yan; Gu, Weikuan; Chen, Hong; Liu, Songjiang

doi:10.7150/jca.87719

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2023; 14(14):2720-2725. doi:10.7150/jca.87719 This issue Cite

Research Paper

Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora

Yushan Dong¹, Jingyu Chen², Heng Sun³, Yuhan Chen⁴, Yan Jiao^6✉, Weikuan Gu⁵, Hong Chen^5✉, Songjiang Liu^3✉

1. Graduate School of Heilongjiang University of Chinese Medicine, No. 24, Heping Road, Xiangfang District, Harbin, Heilongjiang, China, 150040.
2. Department of Chinese Medicine Internal Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. 1, Xiyuan Playground, Haidian District, Beijing, 100091.
3. Department of Chinese Medicine, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine No.26, Heping Road, Xiangfang District, Harbin, Heilongjiang Province, China, 150040.
4. Department of Chinese Medicine, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, 100091.
5. Department of Chinese Medicine, Heilongjiang Academy of Chinese Medicine Sciences, No. 72 Xiangan Street, Xiangfang District, Harbin, China, 150036.
6. Department of Orthopedic Surgery and BME, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

✉ Corresponding authors: Hong Chen, Heilongjiang Academy of Chinese Medicine Sciences, No. 72 Xiangan Street, Xiangfang District, Harbin 150036, China. Email: drchen1314com; Songjiang Liu, The First Affiliated Hospital of Heilongjiang Universit More

Citation:

Dong Y, Chen J, Sun H, Chen Y, Jiao Y, Gu W, Chen H, Liu S. Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora. J Cancer 2023; 14(14):2720-2725. doi:10.7150/jca.87719. https://www.jcancer.org/v14p2720.htm

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Abstract

Colorectal cancer is a common clinical malignant tumor of the digestive tract, and intestinal flora has played an important role in the development of colorectal cancer. Bifidobacteria, as one of the main dominant florae in intestinal tract, can inhibit the occurrence and development of colorectal cancer through various mechanisms. Recent studies have shown that traditional Chinese medicine can regulate the abundance of bifidobacteria in intestinal tract and exhibit anti-tumor effects on colorectal cancer. Detailed investigations have revealed that the mechanisms of bifidobacteria in the treatment of colorectal cancer involve three aspects: the production of short-chain fatty acids, the regulation of the body's immunity, and the regulation of cell apoptosis and differentiation. In this review, we provide an updated summary of recent advances in our understanding of the mechanisms by which traditional Chinese medicine regulate intestinal flora to inhibit colorectal cancer development and metastasis.

Keywords: Bifidobacterium bifidum, Colorectal cancer, Traditional Chinese Medicine, Intestinal flora

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APA

Dong, Y., Chen, J., Sun, H., Chen, Y., Jiao, Y., Gu, W., Chen, H., Liu, S. (2023). Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora. Journal of Cancer, 14(14), 2720-2725. https://doi.org/10.7150/jca.87719.

ACS

Dong, Y.; Chen, J.; Sun, H.; Chen, Y.; Jiao, Y.; Gu, W.; Chen, H.; Liu, S. Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora. J. Cancer 2023, 14 (14), 2720-2725. DOI: 10.7150/jca.87719.

NLM

CSE

Dong Y, Chen J, Sun H, Chen Y, Jiao Y, Gu W, Chen H, Liu S. 2023. Traditional Chinese medicine as a novel therapy for colorectal cancer by modulating intestinal flora. J Cancer. 14(14):2720-2725.

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