Full Text | PDF

Share on facebook Share on tweeters Share on linkedin Share on googleplus

J Cancer 2023; 14(13):2552-2561. doi:10.7150/jca.84460 This issue Cite

Research Paper

HOXC8 mediates osteopontin expression in gastric cancer cells

Chung-Yu Tsai1, Jia‑Bin Liao2, Yi-Chen Lee3, Yi-Fang Yang4✉

1. Division of General Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
2. Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
3. Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
4. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

✉ Corresponding author: Yi-Fang Yang, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, No. 386, Dajhong 1st Rd., Zuoying Dist., Kaohsiung City 813414, Taiwan. Phone: 886-7-342-2121 #71592; Fax: 886-7-342-2288; E-mail: More

Citation:
Tsai CY, Liao J, Lee YC, Yang YF. HOXC8 mediates osteopontin expression in gastric cancer cells. J Cancer 2023; 14(13):2552-2561. doi:10.7150/jca.84460. https://www.jcancer.org/v14p2552.htm
Other styles

File import instruction

Abstract

Graphic abstract

Genes of the homeobox (HOX) family encode transcription factors, which play a role in cancer progression. However, their role in gastric cancer has not been adequately evaluated. Herein, we evaluated the genetic changes and mRNA of target genes of the HOX family in gastric cancer patients using publicly available online datasets. We found that HOXC8 was amplified in gastric cancer tissues, and mRNA expression levels were significantly associated with tumor status (P=0.044) and poor overall survival (P<0.01). HOXC8 knockdown significantly reduced the viability of gastric cancer cell lines. HOXC8 modulated the expression of secreted phosphoprotein 1 (SPP1, osteopontin) and phosphorylation of AKT/ERK in gastric cancer cells. Survival analysis demonstrated a decrease in overall survival rates among the high HOXC8/high SPP1 expression group compared with the low HOXC8/low SPP1 expression group. In conclusion, HOXC8 may be an independent prognostic factor and serve as a useful predictive biomarker for gastric cancer.

Keywords: HOXC8, osteopontin, SPP1, and gastric cancer

Citation styles

APA
Tsai, C.Y., Liao, J., Lee, Y.C., Yang, Y.F. (2023). HOXC8 mediates osteopontin expression in gastric cancer cells. Journal of Cancer, 14(13), 2552-2561. https://doi.org/10.7150/jca.84460.

ACS
Tsai, C.Y.; Liao, J.; Lee, Y.C.; Yang, Y.F. HOXC8 mediates osteopontin expression in gastric cancer cells. J. Cancer 2023, 14 (13), 2552-2561. DOI: 10.7150/jca.84460.

NLM
Tsai CY, Liao J, Lee YC, Yang YF. HOXC8 mediates osteopontin expression in gastric cancer cells. J Cancer 2023; 14(13):2552-2561. doi:10.7150/jca.84460. https://www.jcancer.org/v14p2552.htm

CSE
Tsai CY, Liao J, Lee YC, Yang YF. 2023. HOXC8 mediates osteopontin expression in gastric cancer cells. J Cancer. 14(13):2552-2561.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use