J Cancer 2023; 14(7):1195-1201. doi:10.7150/jca.84470 This issue Cite

Research Paper

The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics

Ping-Ju Chen1,2,3, Chiao-Wen Lin4,5, Hsueh-Ju Lu6,7, Chun-Yi Chuang7,8, Shun-Fa Yang1,9✉, Ying-Erh Chou7,9✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Dentistry, Changhua Christian Hospital, Changhua, Taiwan
3. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
4. Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan
5. Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan
6. Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
7. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
8. Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan

Citation:
Chen PJ, Lin CW, Lu HJ, Chuang CY, Yang SF, Chou YE. The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. J Cancer 2023; 14(7):1195-1201. doi:10.7150/jca.84470. https://www.jcancer.org/v14p1195.htm
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Abstract

Graphic abstract

Oral cancer is the sixth leading cause of cancer mortality worldwide. Genetic, epigenetic, and epidemiological risk factors were suggested to be correlated with the carcinogenesis of oral cancer. In this study, we focused on the correlations of FOXP3 single-nucleotide polymorphisms (SNPs) to oral cancer susceptibility and clinicopathological characteristics. The FOXP3 SNPs rs3761547, rs3761548, rs3761549, and rs2232365 in 1053 controls and 1175 male patients with oral cancer were analyzed with real-time polymerase chain reaction. The results showed that the betel quid chewer who carried the FOXP3 rs3761548 polymorphic variant “T” were significantly associated with lower risk to develop oral cancer [AOR (95% CI) = 0.649 (0.437-0.964); p = 0.032]. The betel quid chewers with genotypic variant “T” of FOXP3 rs3761548 in male oral cancer patients were associated with lower risk of cell differentiated grade [AOR (95% CI) = 0.592 (0.377-0.930); p = 0.023]. The carriers of FOXP3 rs3761548 polymorphic variant “T” in male oral cancer patients with alcohol consumption were associated with lower risk to develop greater tumor [AOR (95% CI) = 0.609 (0.378-0.983); p = 0.042] and lower risk of cell differentiated grade [AOR (95% CI) = 0.440 (0.248-0.779); p = 0.005]. In conclusion, our results have revealed that the FOXP3 rs3761548 polymorphic variant “T” was associated with lower risk of oral cancer susceptibility, greater tumor size, and cell differentiated grade among betel quid chewers. The FOXP3 rs3761548 polymorphisms may play a role as pivotal biomarkers to predict oral cancer disease development and prognosis.

Keywords: oral cancer, FOXP3, polymorphism, betel quid


Citation styles

APA
Chen, P.J., Lin, C.W., Lu, H.J., Chuang, C.Y., Yang, S.F., Chou, Y.E. (2023). The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. Journal of Cancer, 14(7), 1195-1201. https://doi.org/10.7150/jca.84470.

ACS
Chen, P.J.; Lin, C.W.; Lu, H.J.; Chuang, C.Y.; Yang, S.F.; Chou, Y.E. The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. J. Cancer 2023, 14 (7), 1195-1201. DOI: 10.7150/jca.84470.

NLM
Chen PJ, Lin CW, Lu HJ, Chuang CY, Yang SF, Chou YE. The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. J Cancer 2023; 14(7):1195-1201. doi:10.7150/jca.84470. https://www.jcancer.org/v14p1195.htm

CSE
Chen PJ, Lin CW, Lu HJ, Chuang CY, Yang SF, Chou YE. 2023. The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. J Cancer. 14(7):1195-1201.

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