Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center

Zhang, Xiaojie; Wang, Wanqing; Zhao, Lulu; Niu, Penghui; Guo, Chunguang; Zhao, Dongbing; Chen, Yingtai

doi:10.7150/jca.75456

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J Cancer 2022; 13(10):3113-3120. doi:10.7150/jca.75456 This issue Cite

Research Paper

Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center

Xiaojie Zhang^#, Wanqing Wang^#, Lulu Zhao^#, Penghui Niu, Chunguang Guo, Dongbing Zhao^✉, Yingtai Chen^✉

Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
#These authors contributed equally to this study.

✉ Corresponding authors: Dongbing Zhao, MD, Professor, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.17 Panjiayuan Nanli, Beijing, 100021, More

Citation:

Zhang X, Wang W, Zhao L, Niu P, Guo C, Zhao D, Chen Y. Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center. J Cancer 2022; 13(10):3113-3120. doi:10.7150/jca.75456. https://www.jcancer.org/v13p3113.htm

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Abstract

Background: Multivisceral resection is occasionally necessary for pT4b gastric cancer patients to achieve negative margin. The purpose of this study is to assess the short-term safety and long-term efficacy of this approach.

Methods: A single-center, retrospective analysis was conducted for pT4b gastric cancer patients after curative-intent multivisceral resection from the China National Cancer Center Gastric Cancer Database (NCCGCDB) from 1998 to 2018. The postoperative complications, recurrence patterns, long-term survival, and prognostic factors were analyzed.

Results: A total of 210 patients were included in the study. The most common combined resection organs were multiple organs (30.5%), pancreas (20.5%), colon (16.7%), and liver (9.0%). Seventeen patients (8.1%) developed postoperative complications and hospital death was observed in one patient (0.5%). The most common postoperative complications were anastomotic leak (4.3%) and intra-abdominal infection (5.7%). The 3-year and 5-year disease-free survival (DFS) rates for the patients investigated were 38.0% and 33.8%, respectively, and the 3-year and 5-year overall survival (OS) rates were 48.2% and 39.1%, respectively. Multivariate Cox regression analysis proved that negative nerve invasion was independent risk factors for DFS (HR: 2.202, 95%CI: 1.144-4.236, P=0.018) and OS (HR: 2.219, 95%CI: 1.164-4.231, P=0.015).

Conclusions: Multivisceral resection in pT4b gastric cancer patients without distant metastasis was effective and had an acceptable safety profile.

Keywords: gastric cancer, T4b, multivisceral resection (MVR), postoperative complications, recurrence, survival

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APA

Zhang, X., Wang, W., Zhao, L., Niu, P., Guo, C., Zhao, D., Chen, Y. (2022). Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center. Journal of Cancer, 13(10), 3113-3120. https://doi.org/10.7150/jca.75456.

ACS

Zhang, X.; Wang, W.; Zhao, L.; Niu, P.; Guo, C.; Zhao, D.; Chen, Y. Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center. J. Cancer 2022, 13 (10), 3113-3120. DOI: 10.7150/jca.75456.

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CSE

Zhang X, Wang W, Zhao L, Niu P, Guo C, Zhao D, Chen Y. 2022. Short-term safety and Long-term efficacy of multivisceral resection in pT4b gastric cancer patients without distant metastasis: a 20-year experience in China National Cancer Center. J Cancer. 13(10):3113-3120.

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