J Cancer 2022; 13(1):174-183. doi:10.7150/jca.65031 This issue

Review

The roles of long non-coding RNAs in lung cancer

Zhe Cao1*, Linda Oyang1*, Xia Luo1, Longzheng Xia1, Jiaqi Hu1, Jinguan Lin1, Shiming Tan1, Yanyan Tang1,2, Yujuan Zhou1, Deliang Cao1✉, Qianjin Liao1,2✉

1. Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
2. Clinical Research Center for Wound Healing in Hunan Province, Changsha 410013, Hunan, China.
* These authors contributed equally.

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Citation:
Cao Z, Oyang L, Luo X, Xia L, Hu J, Lin J, Tan S, Tang Y, Zhou Y, Cao D, Liao Q. The roles of long non-coding RNAs in lung cancer. J Cancer 2022; 13(1):174-183. doi:10.7150/jca.65031. Available from https://www.jcancer.org/v13p0174.htm

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Abstract

Graphic abstract

Lung cancer is the most common malignancy, being a serious threat of human lives. The incidence and mortality of lung cancer has been increasing rapidly in the past decades. Although the development of new therapeutic modes, such as target therapy, the overall survival rate of lung cancer remains low. It is urgent to advance the understanding of molecular oncology and find novel biomarkers and targets for the early diagnosis, treatment, and prognostic prediction of lung cancer. Long non-coding RNAs (lncRNAs) are non-protein coding RNA transcripts that are more than 200 nucleotides in length. LncRNAs exert diverse biological functions by regulating gene expressions at transcriptional, translational, and post-translational levels. In the past decade, it has been shown that lncRNAs are extensively involved in the pathogenesis of various diseases, including lung cancer. In this review, we highlighted the lncRNAs characterized in lung cancer and discussed their translational potential in lung cancer clinics.

Keywords: LncRNAs, lung cancer, tumor biomarkers, MALAT1, and HOTAIR