J Cancer 2021; 12(23):7111-7119. doi:10.7150/jca.60379 This issue

Review

Colony Stimulating Factor-1 and its Receptor in Gastrointestinal Malignant Tumors

Hong-wu Li, Shi-lei Tang

General Surgery Department, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China, 110032.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Li Hw, Tang Sl. Colony Stimulating Factor-1 and its Receptor in Gastrointestinal Malignant Tumors. J Cancer 2021; 12(23):7111-7119. doi:10.7150/jca.60379. Available from https://www.jcancer.org/v12p7111.htm

File import instruction

Abstract

Graphic abstract

Gastrointestinal malignant tumor is the fourth most common cancer in the world and the second cause of cancer death. Due to the susceptibility to lymphatic metastasis and liver metastasis, the prognosis of advanced tumor patients is still poor till now. With the development of tumor molecular biology, the tumor microenvironment and the cytokines, which are closely related to the proliferation, infiltration and metastasis, have become a research hotspot in life sciences. Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, and its receptor CSF-1R are reported to play important roles in regulating tumor-associated macrophages in tumor microenvironment and participating in the occurrence and development in diversities of cancers. Targeted inhibition of the CSF-1/CSF-1R signal axis has broad application prospects in cancer immunotherapy. Here, we reviewed the biological characters of CSF-1/CSF-1R and their relationship with gastrointestinal malignancies.

Keywords: colony stimulating factor-1, colony stimulating factor-1 receptor, tumor-associated macrophages, gastrointestinal malignant tumors