ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2021; 12(20):6094-6104. doi:10.7150/jca.56098 This issue Cite
Research Paper
miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway
1. Department of Discipline Inspection Commission, China Medical University, Shenyang 110001, Liaoning, China.
2. Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China.
Abstract
Accumulating evidence shows that microRNAs (miRNAs) play key roles in tumorigenesis, progression, recurrence and drug resistance of malignant tumors. The tumor-promoting role of miR-552 has been evidenced in multiple tumors. Yet, the relevance of miR-552 in cervical cancer remains undetermined. This study aimed to investigate the role of miR-552 in cervical cancer proliferation and metastasis. Herein, we for first found that miR-552 expression was upregulated in cervical cancer tissues compared with their normal controls. Functional assays revealed that miR-552 promoted the proliferation and metastasis of cervical cancer cells. Mechanically, bioinformatics and luciferase reporter analysis identified MUC15 as a direct target of miR-552. Reduced MUC15 expression was detected in cervical cancer, and MUC15 overexpression exhibited a tumor-suppressive effect. MUC15 restoration partially abolished the discrepancy of growth and metastasis capacity between miR-552 overexpression cervical cancer cells and control cells. Taken together, these data demonstrate that miR-552 acts as a potential oncogene miRNA in cervical cancer, which exerts its function through targeting MUC15.
Keywords: cervical cancer, miR-552, MUC15, proliferation, metastasis
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