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J Cancer 2021; 12(16):5035-5045. doi:10.7150/jca.59391 This issue Cite

Review

Emerging Diagnostic Potential of Tumor-derived Exosomes

Ruhua Luo*, Mengmeng Liu*, Qian Yang, Huijuan Cheng, Huimin Yang, Minhui Li, Xue Bai, Yue Wang, Honghua Zhang, Shuling Wang✉, Tian Xie✉, Qingchang Tian✉

1. College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
*Co-first authors with equal contributions to this work.

✉ Corresponding authors: Shuling Wang (E-mail: wsling222com); Tian Xie (E-mail: xbsedu.cn); Qingchang Tian (E-mail: tianqcedu.cn).

Citation:
Luo R, Liu M, Yang Q, Cheng H, Yang H, Li M, Bai X, Wang Y, Zhang H, Wang S, Xie T, Tian Q. Emerging Diagnostic Potential of Tumor-derived Exosomes. J Cancer 2021; 12(16):5035-5045. doi:10.7150/jca.59391. https://www.jcancer.org/v12p5035.htm
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Abstract

Graphic abstract

Exosomes carry genetic information originating from their parental cells, raising their possibility as novel noninvasive biomarkers for cancer. Tumor-derived exosomes (TEXs) have a variety of endogenous cargos that reflect the pathophysiology status and information of tumor cells. TEXs are increasingly being recognized as potential biomarkers for cancer diagnosis prognosis, and monitoring. It is important to develop a variety of sensitive methods, including probes and biomaterials to isolate exosomes. A variety of approaches for detecting exosomes have been established. By combining exosome DNA and RNA sequencing tools, exosome proteomics analysis and immunoassay technology, it is expected that exosomes will gain widespread use in the diagnosis and treatment of cancer.

Keywords: exosomes, tumor-derived exosomes, biomarkers, cancer detection

Citation styles

APA
Luo, R., Liu, M., Yang, Q., Cheng, H., Yang, H., Li, M., Bai, X., Wang, Y., Zhang, H., Wang, S., Xie, T., Tian, Q. (2021). Emerging Diagnostic Potential of Tumor-derived Exosomes. Journal of Cancer, 12(16), 5035-5045. https://doi.org/10.7150/jca.59391.

ACS
Luo, R.; Liu, M.; Yang, Q.; Cheng, H.; Yang, H.; Li, M.; Bai, X.; Wang, Y.; Zhang, H.; Wang, S.; Xie, T.; Tian, Q. Emerging Diagnostic Potential of Tumor-derived Exosomes. J. Cancer 2021, 12 (16), 5035-5045. DOI: 10.7150/jca.59391.

NLM
Luo R, Liu M, Yang Q, Cheng H, Yang H, Li M, Bai X, Wang Y, Zhang H, Wang S, Xie T, Tian Q. Emerging Diagnostic Potential of Tumor-derived Exosomes. J Cancer 2021; 12(16):5035-5045. doi:10.7150/jca.59391. https://www.jcancer.org/v12p5035.htm

CSE
Luo R, Liu M, Yang Q, Cheng H, Yang H, Li M, Bai X, Wang Y, Zhang H, Wang S, Xie T, Tian Q. 2021. Emerging Diagnostic Potential of Tumor-derived Exosomes. J Cancer. 12(16):5035-5045.

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