J Cancer 2021; 12(16):4891-4900. doi:10.7150/jca.58582

Review

Chlamydia Trachomatis Infection: Their potential implication in the Etiology of Cervical Cancer

Xingju Yang1, Anam Siddique2, Abdul Arif Khan3, Qian Wang4, Abdul Malik5, Arif Tasleem Jan6, Hassan Ahmed Rudayni7, Anis Ahmad Chaudhary7, Shahanavaj Khan2,5,8✉

1. Department of Nursing, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 271199, China.
2. Department of Biosciences, Shri Ram Group of College (SRGC), Muzaffarnagar 251001, India.
3. Division of Microbiology, Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra, India.
4. Department of Obstetrics and Gynecology, Jinan Fifth People's Hospital, Jinan, Shandong, 250022, China.
5. Department of Pharmaceutics, College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
6. School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185236, India.
7. Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
8. Novel Global Community Educational Foundation, Australia.

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Citation:
Yang X, Siddique A, Khan AA, Wang Q, Malik A, Jan AT, Rudayni HA, Chaudhary AA, Khan S. Chlamydia Trachomatis Infection: Their potential implication in the Etiology of Cervical Cancer. J Cancer 2021; 12(16):4891-4900. doi:10.7150/jca.58582. Available from https://www.jcancer.org/v12p4891.htm

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Abstract

Pathogenic bacterial strains can alter the normal function of cells and induce different levels of inflammatory responses that are connected to the development of different diseases, such as tuberculosis, diarrhea, cancer etc. Chlamydia trachomatis (C. trachomatis) is an intracellular obligate gram-negative bacterium which has been connected with the cervical cancer etiology. Nevertheless, establishment of causality and the underlying mechanisms of carcinogenesis of cervical cancer associated with C. trachomatis remain unclear. Studies reveal the existence of C. trachomatis in cervical cancer patients. The DNA repair pathways including mismatch repair, nucleotide excision, and base excision are vital in the abatement of accumulated mutations that can direct to the process of carcinogenesis. C. trachomatis recruits DDR proteins away from sites of DNA damage and, in this way, impedes the DDR. Therefore, by disturbing host cell-cycle control, chromatin and DDR repair, C. trachomatis makes a situation favorable for malignant transformation. Inflammation originated due to infection directs over production of reactive oxygen species (ROS) and consequent oxidative DNA damage. This review may aid our current understanding of the etiology of cervical cancer in C. trachomatis-infected patients.

Keywords: bacteria, C. trachomatis, infection, C. trachomatis proteins, cervical cancer, etiology