FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment

Liao, Chengcheng; An, Jiaxing; Yi, Suqin; Tan, Zhangxue; Wang, Hui; Li, Hao; Guan, Xiaoyan; Liu, Jianguo; Wang, Qian

doi:10.7150/jca.58268

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J Cancer 2021; 12(13):4109-4120. doi:10.7150/jca.58268 This issue Cite

Review

FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment

Chengcheng Liao¹, Jiaxing An³, Suqin Yi³, Zhangxue Tan¹, Hui Wang³, Hao Li¹, Xiaoyan Guan⁴, Jianguo Liu¹, Qian Wang^1,2✉

1. Special Key Laboratory of Oral Disease Research, Higher Education Institution in Guizhou Province, School of Stomatology, Zunyi Medical University, Zunyi 563006, China.
2. Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi 563006, China.
3. Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
4. Department of Orthodontics II, Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, China.

Citation:

Liao C, An J, Yi S, Tan Z, Wang H, Li H, Guan X, Liu J, Wang Q. FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment. J Cancer 2021; 12(13):4109-4120. doi:10.7150/jca.58268. https://www.jcancer.org/v12p4109.htm

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Abstract

Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas, prostate,breast, oral cavity, oesophagus, and thyroid tumours, diffuse large B-cell lymphoma, ependymoma, medulloblastoma and glioblastoma multiforme and downregulated in gastric cancer. They can be used as markers of cancer diagnosis, occurrence, progression and prognosis. Core fucosylated EGFR, TGFBR, E-cadherin, PD1/PD-L1 and α3β1 integrin are potential targets for tumour therapy. In addition, IGg1 antibody defucosylation can improve antibody affinity, which is another aspect of FUT8 that could be applied to tumour therapy.

Keywords: FUT8, core fucosylation, EGFR, TGF-β receptor, E-cadherin, PD1/PD-L1, α3β1 integrin.

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APA

Liao, C., An, J., Yi, S., Tan, Z., Wang, H., Li, H., Guan, X., Liu, J., Wang, Q. (2021). FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment. Journal of Cancer, 12(13), 4109-4120. https://doi.org/10.7150/jca.58268.

ACS

Liao, C.; An, J.; Yi, S.; Tan, Z.; Wang, H.; Li, H.; Guan, X.; Liu, J.; Wang, Q. FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment. J. Cancer 2021, 12 (13), 4109-4120. DOI: 10.7150/jca.58268.

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CSE

Liao C, An J, Yi S, Tan Z, Wang H, Li H, Guan X, Liu J, Wang Q. 2021. FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment. J Cancer. 12(13):4109-4120.

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