J Cancer 2021; 12(13):3997-4010. doi:10.7150/jca.50743 This issue Cite

Research Paper

ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma

Xu Lin1,2, Zhi-Yong Wang1,2, Gang Xue1,2,3✉, Xiao-Jing Qin1,2, Jing-Fang Wu1,2✉, Geng Zhang1,2

1. Zhangjiakou Key Laboratory of Thyroid Cancer Precision Diagnosis, Hebei North University, Zhangjiakou, 075000, China.
2. Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.
3. Department of Otorhinolaryngology Head and Neck Surgery, Hebei North University, Zhangjiakou, 075000, China.

Citation:
Lin X, Wang ZY, Xue G, Qin XJ, Wu JF, Zhang G. ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. J Cancer 2021; 12(13):3997-4010. doi:10.7150/jca.50743. https://www.jcancer.org/v12p3997.htm
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Abstract

Graphic abstract

Background: Adenosine A1 Receptor (ADORA1) is an adenosine receptor particularly relevant to the immunomodulatory process of malignant tumors. There are growing evidences that dysregulated overexpression of ADORA1 can promote many types of tumorigenesis. However, the expression and prognostic value and mechanism of ADORA1 in thyroid papillary carcinoma have not been reported.

Methods: TCGA, ONCOMINE, UALCAN, cBioPortal, GeneMANIA, LinkedOmics, TIMER, GSCALite, TISIDB and EPIC tools were used in this study.

Results: ADORA1 was overexpressed in papillary thyroid carcinoma compared to paracancerous tissue. And ADORA1 was positively correlated with lymph node metastasis as well as pathological stage in PTC. ADORA1 had diagnostic and prognostic value for PTC. The functions of ADORA1 co-expressed genes were mainly enriched in immune response, immune response-regulation signaling pathway, regulation of leukocyte activation and cancer-related pathways. Besides, ADORA1 expression was significantly correlated with tumor-infiltrating cells and immune biomarkers in PTC. Finally, the high expression of ADORA1 was sensitive to JW-55 drug.

Conclusion: ADORA1 is a diagnostic and a prognostic biomarker for PTC. The expression of ADORA1 is positively correlated with many immunoregulatory factors in PTC.

Keywords: papillary thyroid carcinoma, ADORA1, immune infiltrates, biomarker


Citation styles

APA
Lin, X., Wang, Z.Y., Xue, G., Qin, X.J., Wu, J.F., Zhang, G. (2021). ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. Journal of Cancer, 12(13), 3997-4010. https://doi.org/10.7150/jca.50743.

ACS
Lin, X.; Wang, Z.Y.; Xue, G.; Qin, X.J.; Wu, J.F.; Zhang, G. ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. J. Cancer 2021, 12 (13), 3997-4010. DOI: 10.7150/jca.50743.

NLM
Lin X, Wang ZY, Xue G, Qin XJ, Wu JF, Zhang G. ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. J Cancer 2021; 12(13):3997-4010. doi:10.7150/jca.50743. https://www.jcancer.org/v12p3997.htm

CSE
Lin X, Wang ZY, Xue G, Qin XJ, Wu JF, Zhang G. 2021. ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. J Cancer. 12(13):3997-4010.

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