J Cancer 2021; 12(8):2268-2274. doi:10.7150/jca.51023

Research Paper

Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa

Weijuan Xin1, Xiaodong Gao2*, Peng Zhao3*, Taiyong Wang4, Xue Ding1, Qianyu Wu2✉, Keqin Hua1✉

1. Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen-Yang Road, Shanghai 200090, China.
2. Department of Obstetrics and Gynecology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai 200120, China.
3. Department of Internal Medicine, People's Hospital of Dezhou, 1751 Xinhu Street, Dezhou 253001, China.
4. Department of Oncology, People's Hospital of Dezhou, 1751 Xinhu Street, Dezhou 253001, China.
*The three authors have contributed equally to this work.

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Citation:
Xin W, Gao X, Zhao P, Wang T, Ding X, Wu Q, Hua K. Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa. J Cancer 2021; 12(8):2268-2274. doi:10.7150/jca.51023. Available from https://www.jcancer.org/v12p2268.htm

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Abstract

Objective: The research paid close attention to the function of lncRNA-related endogenous competitive RNAs (ceRNAs) network in endometrial cancer (EC).

Methods: 45 primary endometrial cancer tissues (EC) and 45 normal endometrium (NE) were included in the research. The online software StarbaseV2.0 was made use of forecasting the lncRNA which most likely contained microRNA-200c-3p combining sites and could interact with microRNA-200c-3p. Subsequently, we chose lncRNAs which were consistent with the characteristics of polyadenylation of lncRNAs and lower expression in EC than that of NE. After that, lncRNAs, which were related with the microRNA-200c-3p-noxa network, were identified.

Results: Rp11-379k17.4, a new gene related to endometrial cancer, was identified as noncoding RNA. It was a more effective ceRNA associated with the microRNA-200c-3p-noxa network.

Conclusion: LncRNAs possess microRNA response elements (MREs) and give scope to significant roles in the post-transcriptional mechanism in EC.

Keywords: lncRNA RP11-379k17.4, endometrial cancer, microRNA-200c-3p, noxa, ceRNAs