J Cancer 2021; 12(1):198-206. doi:10.7150/jca.48769

Research Paper

Emerging roles of MiR-133a in human cancers

Yu-Ting Hua1#, Wen-Xiu Xu2#, Hui Li1, Min Xia1✉

1. Department of Gastroenterology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 299 Qingyang Road, Wuxi, Jiangsu 214023, China.
2. Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
#Equal contributors.

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Citation:
Hua YT, Xu WX, Li H, Xia M. Emerging roles of MiR-133a in human cancers. J Cancer 2021; 12(1):198-206. doi:10.7150/jca.48769. Available from https://www.jcancer.org/v12p0198.htm

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Abstract

MicroRNAs (miRNAs) can post-transcriptionally regulate the expression of cancer-relevant genes via binding to the 3'-untranslated region (3'-UTR) of the target mRNAs. MiR-133a, as a miRNA, participate in tumorigenesis, progression, autophagy and drug-resistance in various malignancies. Based on the recent insights, we discuss the functions of miR-133a in physiological and pathological processes and its potential effects on cancer diagnosis, prognosis and therapy.

Keywords: cancer, miRNA, MiR-133a