J Cancer 2021; 12(1):54-64. doi:10.7150/jca.49692

Review

Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications

Shunyao Zhu1, Ziyi Luo1, Xixi Li1, Xi Han2, Senlin Shi1✉, Ting Zhang1✉

1. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
2. Xiaoshan Hosptital of Traditional Chinese Medicine, Hangzhou 311201, China.

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Citation:
Zhu S, Luo Z, Li X, Han X, Shi S, Zhang T. Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications. J Cancer 2021; 12(1):54-64. doi:10.7150/jca.49692. Available from https://www.jcancer.org/v12p0054.htm

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Abstract

Tumor-associated macrophages (TAMs) occupy an important position in the tumor microenvironment (TME), they are a highly plastic heterogeneous population with complex effects on tumorigenesis and development. TAMs secrete a variety of cytokines, chemokines, and proteases, which promote the remodeling of extracellular matrix, tumor cell growth and metastasis, tumor vessel and lymphangiogenesis, and immunosuppression. TAMs with different phenotypes have different effects on tumor proliferation and metastasis. TAMs act a pivotal part in occurrence and development of tumors, and are very attractive target to inhibit tumor growth and metastasis in tumor immunotherapy. This article reviews the interrelationship between TAMs and tumor microenvironment and its related applications in tumor therapy.

Keywords: tumor-associated macrophages (TAMs), tumor microenvironment, tumor immunotherapy