J Cancer 2021; 12(1):38-53. doi:10.7150/jca.49406 This issue Cite

Review

Current Ovarian Cancer Maintenance Strategies and Promising New Developments

Vinaya Gogineni1, Susan Morand1, Hannah Staats1, Rachel Royfman1, Monika Devanaboyina1, Katelyn Einloth1, Danielle Dever1, Laura Stanbery2, Phylicia Aaron2, Luisa Manning2, Adam Walter3, Gerald Edelman1, Lance Dworkin1, John Nemunaitis2✉

1. University of Toledo Medical Center, Toledo, OH
2. Gradalis, Inc, Carrollton, TX
3. Promedica Health System, Toledo, OH

Citation:
Gogineni V, Morand S, Staats H, Royfman R, Devanaboyina M, Einloth K, Dever D, Stanbery L, Aaron P, Manning L, Walter A, Edelman G, Dworkin L, Nemunaitis J. Current Ovarian Cancer Maintenance Strategies and Promising New Developments. J Cancer 2021; 12(1):38-53. doi:10.7150/jca.49406. https://www.jcancer.org/v12p0038.htm
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Abstract

While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of BRCA mutation status, however impact on overall survival is limited. Oliparib was approved for BRCA mutant and BRCA wildtype/homologous recombination deficient patients. This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.

Keywords: ovarian cancer maintenance, HGSOC, ovarian cancer treatment, Vigil


Citation styles

APA
Gogineni, V., Morand, S., Staats, H., Royfman, R., Devanaboyina, M., Einloth, K., Dever, D., Stanbery, L., Aaron, P., Manning, L., Walter, A., Edelman, G., Dworkin, L., Nemunaitis, J. (2021). Current Ovarian Cancer Maintenance Strategies and Promising New Developments. Journal of Cancer, 12(1), 38-53. https://doi.org/10.7150/jca.49406.

ACS
Gogineni, V.; Morand, S.; Staats, H.; Royfman, R.; Devanaboyina, M.; Einloth, K.; Dever, D.; Stanbery, L.; Aaron, P.; Manning, L.; Walter, A.; Edelman, G.; Dworkin, L.; Nemunaitis, J. Current Ovarian Cancer Maintenance Strategies and Promising New Developments. J. Cancer 2021, 12 (1), 38-53. DOI: 10.7150/jca.49406.

NLM
Gogineni V, Morand S, Staats H, Royfman R, Devanaboyina M, Einloth K, Dever D, Stanbery L, Aaron P, Manning L, Walter A, Edelman G, Dworkin L, Nemunaitis J. Current Ovarian Cancer Maintenance Strategies and Promising New Developments. J Cancer 2021; 12(1):38-53. doi:10.7150/jca.49406. https://www.jcancer.org/v12p0038.htm

CSE
Gogineni V, Morand S, Staats H, Royfman R, Devanaboyina M, Einloth K, Dever D, Stanbery L, Aaron P, Manning L, Walter A, Edelman G, Dworkin L, Nemunaitis J. 2021. Current Ovarian Cancer Maintenance Strategies and Promising New Developments. J Cancer. 12(1):38-53.

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