J Cancer 2021; 12(1):38-53. doi:10.7150/jca.49406
Current Ovarian Cancer Maintenance Strategies and Promising New Developments
1. University of Toledo Medical Center, Toledo, OH
2. Gradalis, Inc, Carrollton, TX
3. Promedica Health System, Toledo, OH
Gogineni V, Morand S, Staats H, Royfman R, Devanaboyina M, Einloth K, Dever D, Stanbery L, Aaron P, Manning L, Walter A, Edelman G, Dworkin L, Nemunaitis J. Current Ovarian Cancer Maintenance Strategies and Promising New Developments. J Cancer 2021; 12(1):38-53. doi:10.7150/jca.49406. Available from https://www.jcancer.org/v12p0038.htm
While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of BRCA mutation status, however impact on overall survival is limited. Oliparib was approved for BRCA mutant and BRCA wildtype/homologous recombination deficient patients. This review will focus on current frontline ovarian cancer treatment as well molecularly based approaches to ovarian cancer management.
Keywords: ovarian cancer maintenance, HGSOC, ovarian cancer treatment, Vigil