J Cancer 2021; 12(1):28-37. doi:10.7150/jca.51749

Review

The Essential Factors of Establishing Patient-derived Tumor Model

Chuanzhi Chen, Wu Lin, Yingying Huang, Xiangliu Chen, Haohao Wang, Lisong Teng

Department of Surgical Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

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Citation:
Chen C, Lin W, Huang Y, Chen X, Wang H, Teng L. The Essential Factors of Establishing Patient-derived Tumor Model. J Cancer 2021; 12(1):28-37. doi:10.7150/jca.51749. Available from https://www.jcancer.org/v12p0028.htm

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Abstract

Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research discoveries and to test potential therapeutic approaches. However, research in this field is hampered by the limited engraftment rate. In this review, we go over a large number of researches on patient-derived xenograft transplantation and firstly systematically summarize the main factors in methodology to successfully establish models. These results will be applied to the development of patient-derived xenograft leading to better preclinical research.

Keywords: patient-derived xenograft, take rate, engraftment rate, tumor burden, Hormonal supplements, Humanized mouse